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231 results

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Page 1
Thymosin beta-4 denotes new directions towards developing prosperous anti-aging regenerative therapies.
Bock-Marquette I, Maar K, Maar S, Lippai B, Faskerti G, Gallyas F Jr, Olson EN, Srivastava D. Bock-Marquette I, et al. Int Immunopharmacol. 2023 Mar;116:109741. doi: 10.1016/j.intimp.2023.109741. Epub 2023 Jan 27. Int Immunopharmacol. 2023. PMID: 36709593 Free article. Review.
In this review, we introduce and summarize our results regarding Thymosin beta-4 (TB4) to support our hypothesis using the heart as model system. Accordingly, we investigated the developmental expression of TB4 in mouse embryos and determined the impact of th …
In this review, we introduce and summarize our results regarding Thymosin beta-4 (TB4) to support our hypothesis using …
Intra-Articular Injection of BPC 157 for Multiple Types of Knee Pain.
Lee E, Padgett B. Lee E, et al. Altern Ther Health Med. 2021 Jul;27(4):8-13. Altern Ther Health Med. 2021. PMID: 34324435
Also, referred pain from hip joint pathology like slipped capital femoral epiphysis can result in knee pain.1 The use of peptides BPC157 and thymosin-beta-4 (TB4) has not been studied in the treatment of knee pain. METHODS: A retrospective study was done at t …
Also, referred pain from hip joint pathology like slipped capital femoral epiphysis can result in knee pain.1 The use of peptides BPC157 and …
Thymosin beta 4 and the eye: the journey from bench to bedside.
Sosne G. Sosne G. Expert Opin Biol Ther. 2018 Jul;18(sup1):99-104. doi: 10.1080/14712598.2018.1486818. Expert Opin Biol Ther. 2018. PMID: 30063853 Review.
Thymosin beta 4 (Tbeta4) has important applications in ocular repair and Phase 3 clinical trials using Tbeta4 to treat dry eye and neurotrophic keratopathy are currently ongoing. ...As a tribute to the amazing individuals who have guided and supported …
Thymosin beta 4 (Tbeta4) has important applications in ocular repair and Phase 3 clinical trials using Tbeta4 to …
Thymosin beta4: a multi-functional regenerative peptide. Basic properties and clinical applications.
Goldstein AL, Hannappel E, Sosne G, Kleinman HK. Goldstein AL, et al. Expert Opin Biol Ther. 2012 Jan;12(1):37-51. doi: 10.1517/14712598.2012.634793. Epub 2011 Nov 10. Expert Opin Biol Ther. 2012. PMID: 22074294
INTRODUCTION: Thymosin beta(4), a low molecular weight, naturally-occurring peptide plays a vital role in the repair and regeneration of injured cells and tissues. ...AREAS COVERED: This article will cover the many thymosin beta(4) …
INTRODUCTION: Thymosin beta(4), a low molecular weight, naturally-occurring peptide plays a vital role in the repair …
Thymosin beta 4: A potential novel adjunct treatment for bacterial keratitis.
Sosne G, Berger EA. Sosne G, et al. Int Immunopharmacol. 2023 May;118:109953. doi: 10.1016/j.intimp.2023.109953. Epub 2023 Apr 3. Int Immunopharmacol. 2023. PMID: 37018981 Free PMC article.
To this end, treatments are needed that both regulate the inflammatory response and promote corneal wound healing to resolve visual disturbances and improve quality of life. Thymosin beta 4 is a small, naturally occurring 43-amino-acid protein t …
To this end, treatments are needed that both regulate the inflammatory response and promote corneal wound healing to resolve v …
beta-Thymosins.
Hannappel E. Hannappel E. Ann N Y Acad Sci. 2007 Sep;1112:21-37. doi: 10.1196/annals.1415.018. Epub 2007 Apr 27. Ann N Y Acad Sci. 2007. PMID: 17468232 Review.
The development of thymosin beta(4) from a thymic hormone to an actin-sequestering peptide and back to a cytokine supporting wound healing will be outlined. ...Several biological effects are attributed to thymosin beta(4), o …
The development of thymosin beta(4) from a thymic hormone to an actin-sequestering peptide and back to a cytokine suppo …
Thymosin Beta 4 Is a Potential Regulator of Hepatic Stellate Cells.
Kim J, Jung Y. Kim J, et al. Vitam Horm. 2016;102:121-49. doi: 10.1016/bs.vh.2016.04.011. Epub 2016 May 31. Vitam Horm. 2016. PMID: 27450733 Review.
During liver injury, hepatic stellate cells (HSCs) undergo transdifferentiation from quiescent HSCs into activated HSCs, which promote the deposition of extracellular matrix proteins, leading to liver fibrosis. Thymosin beta 4 (Tbeta4), a major actin-sequeste …
During liver injury, hepatic stellate cells (HSCs) undergo transdifferentiation from quiescent HSCs into activated HSCs, which promote the d …
Thymosin beta-4 - A potential tool in healing middle ear lesions in adult mammals.
Bako P, Lippai B, Nagy J, Kramer S, Kaszas B, Tornoczki T, Bock-Marquette I. Bako P, et al. Int Immunopharmacol. 2023 Mar;116:109830. doi: 10.1016/j.intimp.2023.109830. Epub 2023 Feb 14. Int Immunopharmacol. 2023. PMID: 38706788 Free PMC article.
In addition to classical grafts such as the fascia or cartilage, promising results have been reported with various biological materials including silk or acellular collagen. However, despite of all the efforts, healing remains insufficient. Consequentially, a need for subs …
In addition to classical grafts such as the fascia or cartilage, promising results have been reported with various biological materials incl …
CCN5 suppresses injury-induced vascular restenosis by inhibiting smooth muscle cell proliferation and facilitating endothelial repair via thymosin beta4 and Cd9 pathway.
Zhang Q, Li H, Zhuang T, Xu L, Wu W, Pi J, Zhu P, Geng L, Duan Y, Xu J, Yue J, Liu X, He C, Chen X, Ruan C, Zhuang S, Liu Z, Wang Y, Zhang L, Liu J, Zhang Y. Zhang Q, et al. Eur Heart J. 2025 May 2;46(17):1645-1658. doi: 10.1093/eurheartj/ehae911. Eur Heart J. 2025. PMID: 39873228 Free article.
Endothelial cell- and VSMC-specific CCN5 deletion mice exhibited exacerbation of injury-induced neointimal hyperplasia, while CCN5 gain-of-function alleviated neointimal formation. Mechanistic studies identified thymosin beta4 (Tbeta4) as a CCN5 interacting protein in ECs …
Endothelial cell- and VSMC-specific CCN5 deletion mice exhibited exacerbation of injury-induced neointimal hyperplasia, while CCN5 gain-of-f …
Thymosin beta-4 participate in antibacterial immunity and wound healing in black tiger shrimp, Penaeus monodon.
Lin C, Qiu L, Wang P, Zhang B, Yan L, Zhao C. Lin C, et al. Fish Shellfish Immunol. 2023 Oct;141:109065. doi: 10.1016/j.fsi.2023.109065. Epub 2023 Sep 7. Fish Shellfish Immunol. 2023. PMID: 37689229
Thymosin beta-4 (Tbeta4) is a ubiquitous protein with multiple and diverse intracellular and extracellular functions in vertebrates, which play fundamental roles in innate immune against pathogens and wound healing. ...In vivo, PmTbeta4 could fa …
Thymosin beta-4 (Tbeta4) is a ubiquitous protein with multiple and diverse intracellular and extracellular functions in …
231 results