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121 results

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Page 1
Thymosin beta4: a multi-functional regenerative peptide. Basic properties and clinical applications.
Goldstein AL, Hannappel E, Sosne G, Kleinman HK. Goldstein AL, et al. Expert Opin Biol Ther. 2012 Jan;12(1):37-51. doi: 10.1517/14712598.2012.634793. Epub 2011 Nov 10. Expert Opin Biol Ther. 2012. PMID: 22074294
INTRODUCTION: Thymosin beta(4), a low molecular weight, naturally-occurring peptide plays a vital role in the repair and regeneration of injured cells and tissues. ...AREAS COVERED: This article will cover the many thymosin beta( …
INTRODUCTION: Thymosin beta(4), a low molecular weight, naturally-occurring peptide plays a vital role in the repair …
Thymosin beta-4 denotes new directions towards developing prosperous anti-aging regenerative therapies.
Bock-Marquette I, Maar K, Maar S, Lippai B, Faskerti G, Gallyas F Jr, Olson EN, Srivastava D. Bock-Marquette I, et al. Int Immunopharmacol. 2023 Mar;116:109741. doi: 10.1016/j.intimp.2023.109741. Epub 2023 Jan 27. Int Immunopharmacol. 2023. PMID: 36709593 Free article. Review.
In this review, we introduce and summarize our results regarding Thymosin beta-4 (TB4) to support our hypothesis using the heart as model system. Accordingly, we investigated the developmental expression of TB4 in mouse embryos and determined the impact of th …
In this review, we introduce and summarize our results regarding Thymosin beta-4 (TB4) to support our hypothesis using …
Thymosin beta 4 and the eye: the journey from bench to bedside.
Sosne G. Sosne G. Expert Opin Biol Ther. 2018 Jul;18(sup1):99-104. doi: 10.1080/14712598.2018.1486818. Expert Opin Biol Ther. 2018. PMID: 30063853 Review.
Thymosin beta 4 (Tbeta4) has important applications in ocular repair and Phase 3 clinical trials using Tbeta4 to treat dry eye and neurotrophic keratopathy are currently ongoing. ...As a tribute to the amazing individuals who have guided and supported …
Thymosin beta 4 (Tbeta4) has important applications in ocular repair and Phase 3 clinical trials using Tbeta4 to …
Thymosin beta 4: A potential novel adjunct treatment for bacterial keratitis.
Sosne G, Berger EA. Sosne G, et al. Int Immunopharmacol. 2023 May;118:109953. doi: 10.1016/j.intimp.2023.109953. Epub 2023 Apr 3. Int Immunopharmacol. 2023. PMID: 37018981 Free PMC article.
To this end, treatments are needed that both regulate the inflammatory response and promote corneal wound healing to resolve visual disturbances and improve quality of life. Thymosin beta 4 is a small, naturally occurring 43-amino-acid protein t …
To this end, treatments are needed that both regulate the inflammatory response and promote corneal wound healing to resolve v …
Animal studies with thymosin beta, a multifunctional tissue repair and regeneration peptide.
Philp D, Kleinman HK. Philp D, et al. Ann N Y Acad Sci. 2010 Apr;1194:81-6. doi: 10.1111/j.1749-6632.2010.05479.x. Ann N Y Acad Sci. 2010. PMID: 20536453 Review.
Studies in various animal models of disease and repair with thymosin beta(4) (Tbeta(4)), the major actin-sequestering molecule in mammalian cells, have provided the scientific foundation for the ongoing dermal, corneal, and cardiac wound repa …
Studies in various animal models of disease and repair with thymosin beta(4) (Tbeta(4)), the major actin-sequest …
CCN5 suppresses injury-induced vascular restenosis by inhibiting smooth muscle cell proliferation and facilitating endothelial repair via thymosin beta4 and Cd9 pathway.
Zhang Q, Li H, Zhuang T, Xu L, Wu W, Pi J, Zhu P, Geng L, Duan Y, Xu J, Yue J, Liu X, He C, Chen X, Ruan C, Zhuang S, Liu Z, Wang Y, Zhang L, Liu J, Zhang Y. Zhang Q, et al. Eur Heart J. 2025 May 2;46(17):1645-1658. doi: 10.1093/eurheartj/ehae911. Eur Heart J. 2025. PMID: 39873228 Free article.
Mechanistic studies identified thymosin beta4 (Tbeta4) as a CCN5 interacting protein in ECs and EC-CCN5 promoted injury repair through Tbeta4 cleavage product Ac-SDKP. Also, CCN5rp promoted EC repair to suppress neointimal hyperplasia via interaction with Cd9 …
Mechanistic studies identified thymosin beta4 (Tbeta4) as a CCN5 interacting protein in ECs and EC-CCN5 promoted injury repair …
Thymosin beta-4 - A potential tool in healing middle ear lesions in adult mammals.
Bako P, Lippai B, Nagy J, Kramer S, Kaszas B, Tornoczki T, Bock-Marquette I. Bako P, et al. Int Immunopharmacol. 2023 Mar;116:109830. doi: 10.1016/j.intimp.2023.109830. Epub 2023 Feb 14. Int Immunopharmacol. 2023. PMID: 38706788 Free PMC article.
In addition to classical grafts such as the fascia or cartilage, promising results have been reported with various biological materials including silk or acellular collagen. However, despite of all the efforts, healing remains insufficient. Consequentially, a need for subs …
In addition to classical grafts such as the fascia or cartilage, promising results have been reported with various biological materials incl …
Thymosin beta4: multiple functions in protection, repair and regeneration of the mammalian heart.
Bollini S, Riley PR, Smart N. Bollini S, et al. Expert Opin Biol Ther. 2015;15 Suppl 1:S163-74. doi: 10.1517/14712598.2015.1022526. Epub 2015 Jun 22. Expert Opin Biol Ther. 2015. PMID: 26094634 Review.
This has sustained the development of several regenerative strategies based on the use of stem cells and tissue engineering approaches in order to achieve cardiac repair and regeneration by enhancing coronary neovascularization, modulating acute inflammation and sup …
This has sustained the development of several regenerative strategies based on the use of stem cells and tissue engineering approaches in or …
Thymosin beta 4 and a synthetic peptide containing its actin-binding domain promote dermal wound repair in db/db diabetic mice and in aged mice.
Philp D, Badamchian M, Scheremeta B, Nguyen M, Goldstein AL, Kleinman HK. Philp D, et al. Wound Repair Regen. 2003 Jan-Feb;11(1):19-24. doi: 10.1046/j.1524-475x.2003.11105.x. Wound Repair Regen. 2003. PMID: 12581423
Impaired wound healing is a problem for immobilized patients, diabetics, and the elderly. Thymosin beta 4 has previously been found to promote dermal and corneal repair in normal rats. ...Thymosin beta 4 accelerated …
Impaired wound healing is a problem for immobilized patients, diabetics, and the elderly. Thymosin beta 4 …
Thymosin Beta 4: A Potential Novel Therapy for Neurotrophic Keratopathy, Dry Eye, and Ocular Surface Diseases.
Sosne G, Rimmer D, Kleinman HK, Ousler G. Sosne G, et al. Vitam Horm. 2016;102:277-306. doi: 10.1016/bs.vh.2016.04.012. Epub 2016 Jul 5. Vitam Horm. 2016. PMID: 27450739 Review.
Treatment choices depend on the type and severity of the disease, but in general positive outcomes are limited because many of these treatments do not fully address the underlying disease process or promote mechanisms that facilitate long-term wound repair. From min …
Treatment choices depend on the type and severity of the disease, but in general positive outcomes are limited because many of these treatme …
121 results