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Page 1
Pharmacokinetics of tiludronate in horses: A field population study.
Popot MA, Jacobs M, Garcia P, Loup B, Guyonnet J, Toutain PL, Bailly-Chouriberry L, Bonnaire Y. Popot MA, et al. Equine Vet J. 2018 Jul;50(4):488-492. doi: 10.1111/evj.12789. Epub 2018 Jan 9. Equine Vet J. 2018. PMID: 29194746
BACKGROUND: Tiludronate is a bisphosphonate drug marketed to treat different bone conditions in horses. ...Each horse received 1 mg/kg of tiludronate (Tildren() ) intravenously (i.v.). Blood samples (from 1 to 4 per horse with a total of 93 samp …
BACKGROUND: Tiludronate is a bisphosphonate drug marketed to treat different bone conditions in horses. ...Each horse r …
Retrospective Analysis of the Use of Tiludronate in Equine Practice: Safety on 1804 Horses, Efficacy on 343 Horses.
Tischmacher A, Wilford S, Allen K, Mitchell RD, Parkin T, Denoix JM. Tischmacher A, et al. J Equine Vet Sci. 2022 Aug;115:104007. doi: 10.1016/j.jevs.2022.104007. Epub 2022 May 13. J Equine Vet Sci. 2022. PMID: 35577109 Free article.
The objective of this retrospective study was to assess the safety and efficacy of a slow IV administration of 1mg/kg tiludronate in a large number of horses. Each horse that received at least one tiludronate-based treatment between 2006 and August 201 …
The objective of this retrospective study was to assess the safety and efficacy of a slow IV administration of 1mg/kg tiludronate in …
Tiludronate and clodronate do not affect bone structure or remodeling kinetics over a 60 day randomized trial.
Richbourg HA, Mitchell CF, Gillett AN, McNulty MA. Richbourg HA, et al. BMC Vet Res. 2018 Mar 20;14(1):105. doi: 10.1186/s12917-018-1423-2. BMC Vet Res. 2018. PMID: 29554967 Free PMC article. Clinical Trial.
BACKGROUND: Tiludronate and clodronate are FDA-approved bisphosphonate drug therapies for navicular disease in horses. ...Therefore, the purpose of this randomized, experimental pilot study was to determine the effect of tiludronate and clodronate on normal b …
BACKGROUND: Tiludronate and clodronate are FDA-approved bisphosphonate drug therapies for navicular disease in horses. ...Ther …
Assessment of a bone biopsy technique for measuring tiludronate in horses: a preliminary study.
Delguste C, Doucet M, Gabriel A, Guyonnet J, Lepage OM, Amory H. Delguste C, et al. Can J Vet Res. 2011 Apr;75(2):128-33. Can J Vet Res. 2011. PMID: 21731184 Free PMC article.
This study assessed the feasibility of measuring tiludronate in horses using a minimally invasive bone biopsy technique. Eight horses were treated with intravenous (IV) tiludronate [1 mg/kg bodyweight (BW)], either once (n = 4) or twice, 28 d apart (n …
This study assessed the feasibility of measuring tiludronate in horses using a minimally invasive bone biopsy technique. Eight …
Tiludronate concentrations and cytologic findings in synovial fluid after intravenous regional limb perfusion with tiludronate in horses.
Hunter BG, Duesterdieck-Zellmer KF, Larson MK. Hunter BG, et al. PeerJ. 2015 Apr 28;3:e889. doi: 10.7717/peerj.889. eCollection 2015. PeerJ. 2015. PMID: 25945303 Free PMC article.
Tiludronate concentration was >19,000 ng/ml in DIP joints of two HDT limbs. Tiludronate was measurable only in synovial fluid from HDT limbs 24 h post-perfusion. There were no differences in synovial fluid cytology variables between control and treated limbs. Con …
Tiludronate concentration was >19,000 ng/ml in DIP joints of two HDT limbs. Tiludronate was measurable only in synovial flu …
Effect of intravenous tiludronate disodium administration on the radiographic progression of osteoarthritis of the fetlock joint in Standardbred racehorses.
Bertuglia A, Basano I, Pagliara E, Bottegaro NB, Spinella G, Bullone M. Bertuglia A, et al. J Am Vet Med Assoc. 2021 Sep 15;259(6):651-661. doi: 10.2460/javma.259.6.651. J Am Vet Med Assoc. 2021. PMID: 34448617 Free article.
OBJECTIVE: To compare the effects of tiludronate disodium and 3 other medical treatments on clinical and radiographic findings and biomarkers of disease progression in horses with osteoarthritis of the fetlock joint. ...Horses that received tiludronate …
OBJECTIVE: To compare the effects of tiludronate disodium and 3 other medical treatments on clinical and radiographic findings and bi …
Quantitative assessment of two methods of tiludronate administration for the treatment of lameness caused by navicular syndrome in horses.
Whitfield CT, Schoonover MJ, Holbrook TC, Payton ME, Sippel KM. Whitfield CT, et al. Am J Vet Res. 2016 Feb;77(2):167-73. doi: 10.2460/ajvr.77.2.167. Am J Vet Res. 2016. PMID: 27027711 Free article.
OBJECTIVE: To determine effects of 2 tiludronate administration protocols on measures of lameness in horses with navicular syndrome (NS). ...CONCLUSIONS AND CLINICAL RELEVANCE: Tiludronate (1 mg/kg, IV) as a single systemic treatment appeared to be beneficial …
OBJECTIVE: To determine effects of 2 tiludronate administration protocols on measures of lameness in horses with navicular syn …
Efficacy of tiludronate in the treatment of horses with signs of pain associated with osteoarthritic lesions of the thoracolumbar vertebral column.
Coudry V, Thibaud D, Riccio B, Audigié F, Didierlaurent D, Denoix JM. Coudry V, et al. Am J Vet Res. 2007 Mar;68(3):329-37. doi: 10.2460/ajvr.68.3.329. Am J Vet Res. 2007. PMID: 17331024 Free article. Clinical Trial.
Fifteen horses were randomly assigned to receive tiludronate (1 mg/kg, IV, as a slow-rate infusion), and 14 horses received a control substance (day 0). ...Horses that had no evidence of clinical improvement on day 60 were administered tiludronate …
Fifteen horses were randomly assigned to receive tiludronate (1 mg/kg, IV, as a slow-rate infusion), and 14 horses rece …
Clinically relevant doses of tiludronate do not affect bone remodelling in pasture-exercised horses.
Tippen SP, Metzger CE, Sacks SA, Allen MR, Mitchell CF, McNulty MA. Tippen SP, et al. Equine Vet J. 2025 Mar;57(2):513-521. doi: 10.1111/evj.14119. Epub 2024 Jun 25. Equine Vet J. 2025. PMID: 38924597 Free PMC article.
METHODS: Each horse had a single tuber coxae biopsied (Day 0), then were divided into a treatment (IV tiludronate) or control (IV saline) group. ...The results pertain to the tuber coxae and may not reflect injury or the healing response that occurs in long bones in …
METHODS: Each horse had a single tuber coxae biopsied (Day 0), then were divided into a treatment (IV tiludronate) or control …
Concentration-dependent effects of tiludronate on equine articular cartilage explants incubated with and without interleukin-1beta.
Duesterdieck-Zellmer KF, Driscoll N, Ott JF. Duesterdieck-Zellmer KF, et al. Am J Vet Res. 2012 Oct;73(10):1530-9. doi: 10.2460/ajvr.73.10.1530. Am J Vet Res. 2012. PMID: 23013178 Free article.
Low tiludronate concentrations had some chondroprotective effects, whereas high tiludronate concentrations were detrimental to equine articular cartilage. Administration of tiludronate intra-articularly to horses may be detrimental, dependent on the do …
Low tiludronate concentrations had some chondroprotective effects, whereas high tiludronate concentrations were detrimental to …
29 results