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2003 1
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2010 2
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2017 1
2018 6
2020 0
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Tiludronate and clodronate do not affect bone structure or remodeling kinetics over a 60 day randomized trial.
Richbourg HA, Mitchell CF, Gillett AN, McNulty MA. Richbourg HA, et al. BMC Vet Res. 2018 Mar 20;14(1):105. doi: 10.1186/s12917-018-1423-2. BMC Vet Res. 2018. PMID: 29554967 Free PMC article. Clinical Trial.
BACKGROUND: Tiludronate and clodronate are FDA-approved bisphosphonate drug therapies for navicular disease in horses. Although clinical studies have determined their ability to reduce lameness associated with skeletal disorders in horses, data regarding the …
BACKGROUND: Tiludronate and clodronate are FDA-approved bisphosphonate drug therapies for navicular disease in horses. Althoug …
Pharmacokinetics of tiludronate in horses: A field population study.
Popot MA, Jacobs M, Garcia P, Loup B, Guyonnet J, Toutain PL, Bailly-Chouriberry L, Bonnaire Y. Popot MA, et al. Equine Vet J. 2018 Jul;50(4):488-492. doi: 10.1111/evj.12789. Epub 2018 Jan 9. Equine Vet J. 2018. PMID: 29194746
Each horse received 1 mg/kg of tiludronate (Tildren(®) ) intravenously (i.v.). Blood samples (from 1 to 4 per horse with a total of 93 samples) were collected around 10, 20, 30, 40 and 50 days after tiludronate administration. ...More generally, our st …
Each horse received 1 mg/kg of tiludronate (Tildren(®) ) intravenously (i.v.). Blood samples (from 1 to 4 per horse wit …
Quantitative assessment of intravenous regional limb perfusion of tiludronate as an adjunctive treatment for lameness caused by navicular syndrome in horses.
Schoonover MJ, Whitfield CT, Young JM, Sippel KM, Payton ME. Schoonover MJ, et al. Am J Vet Res. 2018 Dec;79(12):1313-1320. doi: 10.2460/ajvr.79.12.1313. Am J Vet Res. 2018. PMID: 30457899 Clinical Trial.
OBJECTIVE To determine effects for 2 IV regional limb perfusion (IVRLP) protocols involving tiludronate on lameness of horses with navicular syndrome. ...On day 14, horses received 1 of 3 IVRLPs consisting of 0.1 mg of tiludronate/kg (low-dose tilud
OBJECTIVE To determine effects for 2 IV regional limb perfusion (IVRLP) protocols involving tiludronate on lameness of horses
Tiludronate infusion in the treatment of bone spavin: a double blind placebo-controlled trial.
Gough MR, Thibaud D, Smith RK. Gough MR, et al. Equine Vet J. 2010 Jul;42(5):381-7. doi: 10.1111/j.2042-3306.2010.00120.x. Equine Vet J. 2010. PMID: 20636772 Clinical Trial.
OBJECTIVE: To confirm the efficacy of tiludronate, administered as a single infusion at a dose of 1 mg/kg bwt, in the treatment of bone spavin in the horse. ...RESULTS: Eighty-seven horses completed the trial as per the protocol. The tiludronate hor
OBJECTIVE: To confirm the efficacy of tiludronate, administered as a single infusion at a dose of 1 mg/kg bwt, in the treatment of bo …
Quantitative assessment of two methods of tiludronate administration for the treatment of lameness caused by navicular syndrome in horses.
Whitfield CT, Schoonover MJ, Holbrook TC, Payton ME, Sippel KM. Whitfield CT, et al. Am J Vet Res. 2016 Feb;77(2):167-73. doi: 10.2460/ajvr.77.2.167. Am J Vet Res. 2016. PMID: 27027711
OBJECTIVE: To determine effects of 2 tiludronate administration protocols on measures of lameness in horses with navicular syndrome (NS). ...CONCLUSIONS AND CLINICAL RELEVANCE: Tiludronate (1 mg/kg, IV) as a single systemic treatment appeared to be beneficial …
OBJECTIVE: To determine effects of 2 tiludronate administration protocols on measures of lameness in horses with navicular syn …
[Use of bisphosphonates in horses - a review].
Düsterdieck-Zellmer KF. Düsterdieck-Zellmer KF. Tierarztl Prax Ausg G Grosstiere Nutztiere. 2018 Oct;46(5):323-333. doi: 10.15653/TPG-170804. Epub 2018 Oct 19. Tierarztl Prax Ausg G Grosstiere Nutztiere. 2018. PMID: 30340242 German.
Systemic administration of tiludronate or clodronate decreases lameness in some horses suffering from navicular syndrome within 2-6 months of treatment. ...One of the most common side effects of BP treatment in the horse is development of colic signs, which u …
Systemic administration of tiludronate or clodronate decreases lameness in some horses suffering from navicular syndrome withi …
Tiludronate concentrations and cytologic findings in synovial fluid after intravenous regional limb perfusion with tiludronate in horses.
Hunter BG, Duesterdieck-Zellmer KF, Larson MK. Hunter BG, et al. PeerJ. 2015 Apr 28;3:e889. doi: 10.7717/peerj.889. eCollection 2015. PeerJ. 2015. PMID: 25945303 Free PMC article.
Using a randomized controlled experimental study design, horses received IVRLP with LDT (n = 6) or HDT (n = 6) in one forelimb and IVRLP with saline in the contralateral limb. ...In some horses, IVRLP with HDT may result in synovial fluid concentrations of tiludr
Using a randomized controlled experimental study design, horses received IVRLP with LDT (n = 6) or HDT (n = 6) in one forelimb and IV …
Assessment of a bone biopsy technique for measuring tiludronate in horses: a preliminary study.
Delguste C, Doucet M, Gabriel A, Guyonnet J, Lepage OM, Amory H. Delguste C, et al. Can J Vet Res. 2011 Apr;75(2):128-33. Can J Vet Res. 2011. PMID: 21731184 Free PMC article.
This study assessed the feasibility of measuring tiludronate in horses using a minimally invasive bone biopsy technique. Eight horses were treated with intravenous (IV) tiludronate [1 mg/kg bodyweight (BW)], either once (n = 4) or twice, 28 d apart (n …
This study assessed the feasibility of measuring tiludronate in horses using a minimally invasive bone biopsy technique. Eight …
Concentration-dependent effects of tiludronate on equine articular cartilage explants incubated with and without interleukin-1β.
Duesterdieck-Zellmer KF, Driscoll N, Ott JF. Duesterdieck-Zellmer KF, et al. Am J Vet Res. 2012 Oct;73(10):1530-9. doi: 10.2460/ajvr.73.10.1530. Am J Vet Res. 2012. PMID: 23013178
SAMPLE: Articular cartilage explants from the femorotibial joints of 3 young adult horses. PROCEDURES: Cartilage explants were incubated with 1 of 6 concentrations (0, 0.19, 1.9, 19, 190, or 1,900 mg/L) of tiludronate and with or without rEq IL-1 (0.01 ng/mL) for 96 …
SAMPLE: Articular cartilage explants from the femorotibial joints of 3 young adult horses. PROCEDURES: Cartilage explants were incuba …
Efficacy of tiludronate in the treatment of horses with signs of pain associated with osteoarthritic lesions of the thoracolumbar vertebral column.
Coudry V, Thibaud D, Riccio B, Audigié F, Didierlaurent D, Denoix JM. Coudry V, et al. Am J Vet Res. 2007 Mar;68(3):329-37. doi: 10.2460/ajvr.68.3.329. Am J Vet Res. 2007. PMID: 17331024 Clinical Trial.
Fifteen horses were randomly assigned to receive tiludronate (1 mg/kg, IV, as a slow-rate infusion), and 14 horses received a control substance (day 0). ...RESULTS: Horses treated with tiludronate had significant improvement in dorsal flexibilit …
Fifteen horses were randomly assigned to receive tiludronate (1 mg/kg, IV, as a slow-rate infusion), and 14 horses rece …
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