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Fasting, Circadian Rhythms, and Time-Restricted Feeding in Healthy Lifespan.
Longo VD, Panda S. Longo VD, et al. Cell Metab. 2016 Jun 14;23(6):1048-1059. doi: 10.1016/j.cmet.2016.06.001. Cell Metab. 2016. PMID: 27304506 Free PMC article. Review.
Most animals alternate periods of feeding with periods of fasting often coinciding with sleep. Upon >24 hr of fasting, humans, rodents, and other mammals enter alternative metabolic phases, which rely less on glucose and more on ketone body-like carbon sou …
Most animals alternate periods of feeding with periods of fasting often coinciding with sleep. Upon >24 hr of fasting
Impact of intermittent fasting on health and disease processes.
Mattson MP, Longo VD, Harvie M. Mattson MP, et al. Ageing Res Rev. 2017 Oct;39:46-58. doi: 10.1016/j.arr.2016.10.005. Epub 2016 Oct 31. Ageing Res Rev. 2017. PMID: 27810402 Free PMC article. Review.
We use the term periodic fasting (PF) to refer to IF with periods of fasting or fasting mimicking diets lasting from 2 to as many as 21 or more days. In laboratory rats and mice IF and PF have profound beneficial effects on many different indices of health an …
We use the term periodic fasting (PF) to refer to IF with periods of fasting or fasting mimicking diets lasting from 2 …
Fasting: molecular mechanisms and clinical applications.
Longo VD, Mattson MP. Longo VD, et al. Cell Metab. 2014 Feb 4;19(2):181-92. doi: 10.1016/j.cmet.2013.12.008. Epub 2014 Jan 16. Cell Metab. 2014. PMID: 24440038 Free PMC article. Review.
In lower eukaryotes, chronic fasting extends longevity, in part, by reprogramming metabolic and stress resistance pathways. ...Thus, fasting has the potential to delay aging and help prevent and treat diseases while minimizing the side effects caused by chronic diet …
In lower eukaryotes, chronic fasting extends longevity, in part, by reprogramming metabolic and stress resistance pathways. ...Thus, …
Fasting and cancer: molecular mechanisms and clinical application.
Nencioni A, Caffa I, Cortellino S, Longo VD. Nencioni A, et al. Nat Rev Cancer. 2018 Nov;18(11):707-719. doi: 10.1038/s41568-018-0061-0. Nat Rev Cancer. 2018. PMID: 30327499 Free PMC article. Review.
While fasting is hardly tolerated by patients, both animal and clinical studies show that cycles of low-calorie FMDs are feasible and overall safe. Several clinical trials evaluating the effect of fasting or FMDs on treatment-emergent adverse events and on efficacy …
While fasting is hardly tolerated by patients, both animal and clinical studies show that cycles of low-calorie FMDs are feasible and …
Protein Quantity and Source, Fasting-Mimicking Diets, and Longevity.
Brandhorst S, Longo VD. Brandhorst S, et al. Adv Nutr. 2019 Nov 1;10(Suppl_4):S340-S350. doi: 10.1093/advances/nmz079. Adv Nutr. 2019. PMID: 31728501 Free PMC article. Review.
Dietary modifications, including caloric restriction, dietary restriction, various intervals of fasting, and even limiting the time when food is consumed can have a pronounced impact on longevity. ...However, chronic dietary interventions are likely not feasible for …
Dietary modifications, including caloric restriction, dietary restriction, various intervals of fasting, and even limiting the tim
Fasting-mimicking diet and hormone therapy induce breast cancer regression.
Caffa I, Spagnolo V, Vernieri C, Valdemarin F, Becherini P, Wei M, Brandhorst S, Zucal C, Driehuis E, Ferrando L, Piacente F, Tagliafico A, Cilli M, Mastracci L, Vellone VG, Piazza S, Cremonini AL, Gradaschi R, Mantero C, Passalacqua M, Ballestrero A, Zoppoli G, Cea M, Arrighi A, Odetti P, Monacelli F, Salvadori G, Cortellino S, Clevers H, De Braud F, Sukkar SG, Provenzani A, Longo VD, Nencioni A. Caffa I, et al. Nature. 2020 Jul;583(7817):620-624. doi: 10.1038/s41586-020-2502-7. Epub 2020 Jul 15. Nature. 2020. PMID: 32669709 Free PMC article.
Here we show that in mouse models of hormone-receptor-positive breast cancer, periodic fasting or a fasting-mimicking diet(3-5) enhances the activity of the endocrine therapeutics tamoxifen and fulvestrant by lowering circulating IGF1, insulin and leptin and by inhi …
Here we show that in mouse models of hormone-receptor-positive breast cancer, periodic fasting or a fasting-mimicking diet(3-5 …
Fasting-mimicking diet and markers/risk factors for aging, diabetes, cancer, and cardiovascular disease.
Wei M, Brandhorst S, Shelehchi M, Mirzaei H, Cheng CW, Budniak J, Groshen S, Mack WJ, Guen E, Di Biase S, Cohen P, Morgan TE, Dorff T, Hong K, Michalsen A, Laviano A, Longo VD. Wei M, et al. Sci Transl Med. 2017 Feb 15;9(377):eaai8700. doi: 10.1126/scitranslmed.aai8700. Sci Transl Med. 2017. PMID: 28202779 Free PMC article. Clinical Trial.
We randomized 100 generally healthy participants from the United States into two study arms and tested the effects of a fasting-mimicking diet (FMD)-low in calories, sugars, and protein but high in unsaturated fats-on markers/risk factors associated with aging and age-rela …
We randomized 100 generally healthy participants from the United States into two study arms and tested the effects of a fasting-mimic …
Nutrition and fasting mimicking diets in the prevention and treatment of autoimmune diseases and immunosenescence.
Choi IY, Lee C, Longo VD. Choi IY, et al. Mol Cell Endocrinol. 2017 Nov 5;455:4-12. doi: 10.1016/j.mce.2017.01.042. Epub 2017 Jan 28. Mol Cell Endocrinol. 2017. PMID: 28137612 Free PMC article. Review.
Here, we review the dysregulation of lymphocytes during autoimmunity and aging, the mechanisms associated with loss of immune function, and how fasting mimicking diets and other dietary interventions affect autoimmunity and immunosenescence....
Here, we review the dysregulation of lymphocytes during autoimmunity and aging, the mechanisms associated with loss of immune function, and …
Starvation, Stress Resistance, and Cancer.
Buono R, Longo VD. Buono R, et al. Trends Endocrinol Metab. 2018 Apr;29(4):271-280. doi: 10.1016/j.tem.2018.01.008. Epub 2018 Feb 17. Trends Endocrinol Metab. 2018. PMID: 29463451 Free PMC article. Review.
Cancer cells are characterized by dysregulation in signal transduction and metabolic pathways leading to increased glucose uptake, altered mitochondrial function, and the evasion of antigrowth signals. Fasting and fasting-mimicking diets (FMDs) provide a particularl …
Cancer cells are characterized by dysregulation in signal transduction and metabolic pathways leading to increased glucose uptake, altered m …
Interventions to Slow Aging in Humans: Are We Ready?
Longo VD, Antebi A, Bartke A, Barzilai N, Brown-Borg HM, Caruso C, Curiel TJ, de Cabo R, Franceschi C, Gems D, Ingram DK, Johnson TE, Kennedy BK, Kenyon C, Klein S, Kopchick JJ, Lepperdinger G, Madeo F, Mirisola MG, Mitchell JR, Passarino G, Rudolph KL, Sedivy JM, Shadel GS, Sinclair DA, Spindler SR, Suh Y, Vijg J, Vinciguerra M, Fontana L. Longo VD, et al. Aging Cell. 2015 Aug;14(4):497-510. doi: 10.1111/acel.12338. Epub 2015 Apr 22. Aging Cell. 2015. PMID: 25902704 Free PMC article. Review.
These were: (i) dietary interventions mimicking chronic dietary restriction (periodic fasting mimicking diets, protein restriction, etc.); (ii) drugs that inhibit the growth hormone/IGF-I axis; (iii) drugs that inhibit the mTOR-S6K pathway; or (iv) drugs that activate AMPK …
These were: (i) dietary interventions mimicking chronic dietary restriction (periodic fasting mimicking diets, protein restriction, e …
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