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Page 1
Digital Representation of Patients as Medical Digital Twins: Data-Centric Viewpoint.
Demuth S, De Sèze J, Edan G, Ziemssen T, Simon F, Gourraud PA. Demuth S, et al. Among authors: ziemssen t. JMIR Med Inform. 2025 Jan 28;13:e53542. doi: 10.2196/53542. JMIR Med Inform. 2025. PMID: 39881430 Free PMC article.
However, the concept is ambiguous when it comes to practical implementations. Here, we propose a medical digital twin framework with a data-centric approach. We argue that a single digital representation of patients cannot support all the data uses of digi …
However, the concept is ambiguous when it comes to practical implementations. Here, we propose a medical digital twin framewor …
Toward mechanistic medical digital twins: some use cases in immunology.
Laubenbacher R, Adler F, An G, Castiglione F, Eubank S, Fonseca LL, Glazier J, Helikar T, Jett-Tilton M, Kirschner D, Macklin P, Mehrad B, Moore B, Pasour V, Shmulevich I, Smith A, Voigt I, Yankeelov TE, Ziemssen T. Laubenbacher R, et al. Among authors: ziemssen t. Front Digit Health. 2024 Mar 7;6:1349595. doi: 10.3389/fdgth.2024.1349595. eCollection 2024. Front Digit Health. 2024. PMID: 38515550 Free PMC article. Review.
Such personalized models are increasingly referred to as medical digital twins. Digital twin technology for health applications is still in its infancy, and extensive research and development is required. This article focuses on several projects in dif …
Such personalized models are increasingly referred to as medical digital twins. Digital twin technology for heal …
Building digital patient pathways for the management and treatment of multiple sclerosis.
Wenk J, Voigt I, Inojosa H, Schlieter H, Ziemssen T. Wenk J, et al. Among authors: ziemssen t. Front Immunol. 2024 Feb 15;15:1356436. doi: 10.3389/fimmu.2024.1356436. eCollection 2024. Front Immunol. 2024. PMID: 38433832 Free PMC article. Review.
Against this background, we argue that the concept of pathways in healthcare now could be applied to structure the collection of information across multiple devices and stakeholders in the virtual sphere, enabling us to exploit the full potential of AI technology by e.g., buildin …
Against this background, we argue that the concept of pathways in healthcare now could be applied to structure the collection of information …
Forum on immune digital twins: a meeting report.
Laubenbacher R, Adler F, An G, Castiglione F, Eubank S, Fonseca LL, Glazier J, Helikar T, Jett-Tilton M, Kirschner D, Macklin P, Mehrad B, Moore B, Pasour V, Shmulevich I, Smith A, Voigt I, Yankeelov TE, Ziemssen T. Laubenbacher R, et al. Among authors: ziemssen t. NPJ Syst Biol Appl. 2024 Feb 16;10(1):19. doi: 10.1038/s41540-024-00345-5. NPJ Syst Biol Appl. 2024. PMID: 38365857 Free PMC article. Review.
In February 2023, an international group of experts convened for two days to discuss these challenges related to immune digital twins. The group consisted of clinicians, immunologists, biologists, and mathematical modelers, representative of the interdisciplinary na …
In February 2023, an international group of experts convened for two days to discuss these challenges related to immune digital tw …
Digital Biomarkers in Multiple Sclerosis.
Dillenseger A, Weidemann ML, Trentzsch K, Inojosa H, Haase R, Schriefer D, Voigt I, Scholz M, Akgün K, Ziemssen T. Dillenseger A, et al. Among authors: ziemssen t. Brain Sci. 2021 Nov 16;11(11):1519. doi: 10.3390/brainsci11111519. Brain Sci. 2021. PMID: 34827518 Free PMC article. Review.
Despite the great benefit of such increasing digitalization, for now, the path to implementing digital biomarkers is widely unknown or inconsistent. ...In this narrative review, we explore existing and future opportunities to capture clinical digital biomarke …
Despite the great benefit of such increasing digitalization, for now, the path to implementing digital biomarkers is widely un …
Digital Twins for Multiple Sclerosis.
Voigt I, Inojosa H, Dillenseger A, Haase R, Akgün K, Ziemssen T. Voigt I, et al. Among authors: ziemssen t. Front Immunol. 2021 May 3;12:669811. doi: 10.3389/fimmu.2021.669811. eCollection 2021. Front Immunol. 2021. PMID: 34012452 Free PMC article. Review.
In this review, we focus on the advantages, challenges and practical aspects of digital twins in the management of MS. We discuss the use of digital twins for MS as a revolutionary tool to improve diagnosis, monitoring and therapy refining patients' we …
In this review, we focus on the advantages, challenges and practical aspects of digital twins in the management of MS. We disc …