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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
2000 1
2001 2
2002 6
2003 11
2004 21
2005 27
2006 43
2007 57
2008 42
2009 60
2010 74
2011 71
2012 79
2013 62
2014 71
2015 68
2016 77
2017 62
2018 53
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2020 73
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2022 95
2023 86
2024 28

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1,166 results

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Page 1
Role of Toll-like receptors in the pathogenesis of COVID-19.
Khanmohammadi S, Rezaei N. Khanmohammadi S, et al. J Med Virol. 2021 May;93(5):2735-2739. doi: 10.1002/jmv.26826. Epub 2021 Feb 9. J Med Virol. 2021. PMID: 33506952 Free PMC article. Review.
Activation of TLR pathways leads to secretion of pro-inflammatory cytokines, such as interleukin-1 (IL-1), IL-6, and tumor necrosis factor-alpha, as well as type 1 interferon. Different TLRs, like TLR2, TLR3, TLR4, TLR6, TLR7, TLR8, and TLR9 are potentially important in CO …
Activation of TLR pathways leads to secretion of pro-inflammatory cytokines, such as interleukin-1 (IL-1), IL-6, and tumor necrosis factor-a …
TLR2 senses the SARS-CoV-2 envelope protein to produce inflammatory cytokines.
Zheng M, Karki R, Williams EP, Yang D, Fitzpatrick E, Vogel P, Jonsson CB, Kanneganti TD. Zheng M, et al. Nat Immunol. 2021 Jul;22(7):829-838. doi: 10.1038/s41590-021-00937-x. Epub 2021 May 7. Nat Immunol. 2021. PMID: 33963333 Free PMC article.
Mechanistically, TLR2 and Myd88 were required for beta-coronavirus-induced inflammatory responses, and TLR2-dependent signaling induced the production of proinflammatory cytokines during coronavirus infection independent of viral entry. TLR2 sensed the SARS-C …
Mechanistically, TLR2 and Myd88 were required for beta-coronavirus-induced inflammatory responses, and TLR2-dependent signalin …
SARS-CoV-2 spike protein induces inflammation via TLR2-dependent activation of the NF-kappaB pathway.
Khan S, Shafiei MS, Longoria C, Schoggins JW, Savani RC, Zaki H. Khan S, et al. Elife. 2021 Dec 6;10:e68563. doi: 10.7554/eLife.68563. Elife. 2021. PMID: 34866574 Free PMC article.
Further, such an activation of the NF-kappaB pathway was abrogated in Tlr2-deficient macrophages. Consistently, administration of S protein-induced IL-6, TNF-alpha, and IL-1beta in wild-type, but not Tlr2-deficient mice. Notably, upon recognition of S protein, TL
Further, such an activation of the NF-kappaB pathway was abrogated in Tlr2-deficient macrophages. Consistently, administration of S p …
C-type lectins and extracellular vesicles in virus-induced NETosis.
Sung PS, Hsieh SL. Sung PS, et al. J Biomed Sci. 2021 Jun 11;28(1):46. doi: 10.1186/s12929-021-00741-7. J Biomed Sci. 2021. PMID: 34116654 Free PMC article. Review.
The DV-activated EXOs (DV-EXOs) and MVs (DV-MVs) stimulate CLEC5A and Toll-like receptor 2 (TLR2), respectively, to enhance NET formation and inflammatory reactions. Thus, EVs from virus-activated platelets (PLT-EVs) are potent endogenous danger signals, and blockad …
The DV-activated EXOs (DV-EXOs) and MVs (DV-MVs) stimulate CLEC5A and Toll-like receptor 2 (TLR2), respectively, to enhance NET forma …
Viral proteins recognized by different TLRs.
Zhou R, Liu L, Wang Y. Zhou R, et al. J Med Virol. 2021 Nov;93(11):6116-6123. doi: 10.1002/jmv.27265. Epub 2021 Aug 17. J Med Virol. 2021. PMID: 34375002 Review.
Virus invasion activates the host's innate immune response, inducing the production of numerous cytokines and interferons to eliminate pathogens. ...These viruses are all enveloped, including respiratory syncytial virus, hepatitis C virus, measles v
Virus invasion activates the host's innate immune response, inducing the production of numerous cytokines and interferons to eliminat
What triggers inflammation in COVID-19?
Sawa T, Akaike T. Sawa T, et al. Elife. 2022 Jan 20;11:e76231. doi: 10.7554/eLife.76231. Elife. 2022. PMID: 35049500 Free PMC article.
TLRs: Innate Immune Sentries against SARS-CoV-2 Infection.
Mantovani S, Oliviero B, Varchetta S, Renieri A, Mondelli MU. Mantovani S, et al. Int J Mol Sci. 2023 Apr 29;24(9):8065. doi: 10.3390/ijms24098065. Int J Mol Sci. 2023. PMID: 37175768 Free PMC article. Review.
It has been demonstrated that they contribute to the dysregulated immune response observed in patients with severe COVID-19. TLR2, TLR3, TLR4 and TLR7 have been associated with COVID-19 severity. Here, we review the role of TLRs in the etiology and pathogenesis of COVID-19 …
It has been demonstrated that they contribute to the dysregulated immune response observed in patients with severe COVID-19. TLR2, TL …
Anti-inflammatory and anti-viral actions of anionic pulmonary surfactant phospholipids.
Numata M, Voelker DR. Numata M, et al. Biochim Biophys Acta Mol Cell Biol Lipids. 2022 Jun;1867(6):159139. doi: 10.1016/j.bbalip.2022.159139. Epub 2022 Feb 28. Biochim Biophys Acta Mol Cell Biol Lipids. 2022. PMID: 35240310 Free PMC article. Review.
Two minor components of pulmonary surfactant phospholipids, phosphatidylglycerol (PG) and phosphatidylinositol (PI), are present within the alveoli at very high concentrations, and exert anti-inflammatory effects by regulating multiple Toll like receptors (TLR2/1, TLR4, an …
Two minor components of pulmonary surfactant phospholipids, phosphatidylglycerol (PG) and phosphatidylinositol (PI), are present within the …
Does SARS-CoV-2 affect neurodegenerative disorders? TLR2, a potential receptor for SARS-CoV-2 in the CNS.
Szabo MP, Iba M, Nath A, Masliah E, Kim C. Szabo MP, et al. Exp Mol Med. 2022 Apr;54(4):447-454. doi: 10.1038/s12276-022-00755-7. Epub 2022 Apr 8. Exp Mol Med. 2022. PMID: 35396576 Free PMC article. Review.
As ACE2 expression is low in the central nervous system (CNS), these neurological symptoms are unlikely to be caused by ACE2-virus binding. In this review, we will discuss a proposed interaction between SARS-CoV-2 and Toll-like receptor 2 (TLR2) in the CNS. ...In ad …
As ACE2 expression is low in the central nervous system (CNS), these neurological symptoms are unlikely to be caused by ACE2-virus bi …
Interplay between dengue virus and Toll-like receptors, RIG-I/MDA5 and microRNAs: Implications for pathogenesis.
Urcuqui-Inchima S, Cabrera J, Haenni AL. Urcuqui-Inchima S, et al. Antiviral Res. 2017 Nov;147:47-57. doi: 10.1016/j.antiviral.2017.09.017. Epub 2017 Sep 28. Antiviral Res. 2017. PMID: 28965915 Review.
Recognition by TLR2 and TLR4 also promotes the activation of other intracellular pathways and alters viral replication in an interferon-independent manner. ...To accomplish this, miRNAs bind either directly to viral RNA, through base-pair complementarity affecting translat …
Recognition by TLR2 and TLR4 also promotes the activation of other intracellular pathways and alters viral replication in an interfer …
1,166 results