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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
2000 1
2001 2
2002 6
2003 11
2004 21
2005 27
2006 43
2007 57
2008 42
2009 60
2010 74
2011 71
2012 79
2013 62
2014 71
2015 68
2016 77
2017 61
2018 53
2019 65
2020 73
2021 85
2022 31
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1,015 results
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Page 1
Role of Toll-like receptors in the pathogenesis of COVID-19.
Khanmohammadi S, Rezaei N. Khanmohammadi S, et al. J Med Virol. 2021 May;93(5):2735-2739. doi: 10.1002/jmv.26826. Epub 2021 Feb 9. J Med Virol. 2021. PMID: 33506952 Free PMC article. Review.
Activation of TLR pathways leads to secretion of pro-inflammatory cytokines, such as interleukin-1 (IL-1), IL-6, and tumor necrosis factor-alpha, as well as type 1 interferon. Different TLRs, like TLR2, TLR3, TLR4, TLR6, TLR7, TLR8, and TLR9 are potentially important in CO …
Activation of TLR pathways leads to secretion of pro-inflammatory cytokines, such as interleukin-1 (IL-1), IL-6, and tumor necrosis factor-a …
TLR2 senses the SARS-CoV-2 envelope protein to produce inflammatory cytokines.
Zheng M, Karki R, Williams EP, Yang D, Fitzpatrick E, Vogel P, Jonsson CB, Kanneganti TD. Zheng M, et al. Nat Immunol. 2021 Jul;22(7):829-838. doi: 10.1038/s41590-021-00937-x. Epub 2021 May 7. Nat Immunol. 2021. PMID: 33963333 Free PMC article.
Mechanistically, TLR2 and Myd88 were required for beta-coronavirus-induced inflammatory responses, and TLR2-dependent signaling induced the production of proinflammatory cytokines during coronavirus infection independent of viral entry. TLR2 sensed the SARS-C …
Mechanistically, TLR2 and Myd88 were required for beta-coronavirus-induced inflammatory responses, and TLR2-dependent signalin …
Inhibition of curcumin on influenza A virus infection and influenzal pneumonia via oxidative stress, TLR2/4, p38/JNK MAPK and NF-κB pathways.
Dai J, Gu L, Su Y, Wang Q, Zhao Y, Chen X, Deng H, Li W, Wang G, Li K. Dai J, et al. Int Immunopharmacol. 2018 Jan;54:177-187. doi: 10.1016/j.intimp.2017.11.009. Epub 2017 Nov 15. Int Immunopharmacol. 2018. PMID: 29153953
Oxidative stress, Nrf2-HO-1 and TLR-MAPK/NF-kappaB signaling pathways have been proved to be involved in influenza A virus (IAV) replication and influenzal pneumonia. In the previous studies, we have performed several high-throughput drug screenings based on the TLR pathwa …
Oxidative stress, Nrf2-HO-1 and TLR-MAPK/NF-kappaB signaling pathways have been proved to be involved in influenza A virus (IAV) repl …
SARS-CoV-2 spike protein induces inflammation via TLR2-dependent activation of the NF-κB pathway.
Khan S, Shafiei MS, Longoria C, Schoggins JW, Savani RC, Zaki H. Khan S, et al. Elife. 2021 Dec 6;10:e68563. doi: 10.7554/eLife.68563. Elife. 2021. PMID: 34866574 Free PMC article.
Further, such an activation of the NF-kappaB pathway was abrogated in Tlr2-deficient macrophages. Consistently, administration of S protein-induced IL-6, TNF-alpha, and IL-1beta in wild-type, but not Tlr2-deficient mice. Notably, upon recognition of S protein, TL
Further, such an activation of the NF-kappaB pathway was abrogated in Tlr2-deficient macrophages. Consistently, administration of S p …
Viral proteins recognized by different TLRs.
Zhou R, Liu L, Wang Y. Zhou R, et al. J Med Virol. 2021 Nov;93(11):6116-6123. doi: 10.1002/jmv.27265. Epub 2021 Aug 17. J Med Virol. 2021. PMID: 34375002 Review.
Virus invasion activates the host's innate immune response, inducing the production of numerous cytokines and interferons to eliminate pathogens. ...These viruses are all enveloped, including respiratory syncytial virus, hepatitis C virus, measles v
Virus invasion activates the host's innate immune response, inducing the production of numerous cytokines and interferons to eliminat
C-type lectins and extracellular vesicles in virus-induced NETosis.
Sung PS, Hsieh SL. Sung PS, et al. J Biomed Sci. 2021 Jun 11;28(1):46. doi: 10.1186/s12929-021-00741-7. J Biomed Sci. 2021. PMID: 34116654 Free PMC article. Review.
The DV-activated EXOs (DV-EXOs) and MVs (DV-MVs) stimulate CLEC5A and Toll-like receptor 2 (TLR2), respectively, to enhance NET formation and inflammatory reactions. Thus, EVs from virus-activated platelets (PLT-EVs) are potent endogenous danger signals, and blockad …
The DV-activated EXOs (DV-EXOs) and MVs (DV-MVs) stimulate CLEC5A and Toll-like receptor 2 (TLR2), respectively, to enhance NET forma …
Capsid proteins of foot-and-mouth disease virus interact with TLR2 and CD14 to induce cytokine production.
Lin YT, Chen YP, Fang CH, Huang PY, Liang SM. Lin YT, et al. Immunol Lett. 2020 Jul;223:10-16. doi: 10.1016/j.imlet.2020.04.008. Epub 2020 Apr 22. Immunol Lett. 2020. PMID: 32333963
In this study, we first found that binary ethylenimine inactivated-FMDV (BEI-FMDV) with structurally intact capsid activated TLR2, but not other TLRs, and this specific activation was blocked by anti-TLR2 Abs or knockout of TLR2. ...Immunoprecipitation of eit …
In this study, we first found that binary ethylenimine inactivated-FMDV (BEI-FMDV) with structurally intact capsid activated TLR2, bu …
TLR2 on blood monocytes senses dengue virus infection and its expression correlates with disease pathogenesis.
Aguilar-Briseño JA, Upasani V, Ellen BMT, Moser J, Pauzuolis M, Ruiz-Silva M, Heng S, Laurent D, Choeung R, Dussart P, Cantaert T, Smit JM, Rodenhuis-Zybert IA. Aguilar-Briseño JA, et al. Nat Commun. 2020 Jun 23;11(1):3177. doi: 10.1038/s41467-020-16849-7. Nat Commun. 2020. PMID: 32576819 Free PMC article.
Moreover, TLR2 block prior to DENV infection of peripheral blood mononuclear cells prevents activation of human vascular endothelium, suggesting a potential role of the TLR2-responses in vascular integrity. ...Altogether, these data identify a role for TLR2 i …
Moreover, TLR2 block prior to DENV infection of peripheral blood mononuclear cells prevents activation of human vascular endothelium, …
Proteomic landscape of Japanese encephalitis virus-infected fibroblasts.
Sharma KB, Chhabra S, Aggarwal S, Tripathi A, Banerjee A, Yadav AK, Vrati S, Kalia M. Sharma KB, et al. J Gen Virol. 2021 Sep;102(9). doi: 10.1099/jgv.0.001657. J Gen Virol. 2021. PMID: 34546869
Advances in proteomics have enabled a comprehensive understanding of host-pathogen interactions. Here we have characterized Japanese encephalitis virus (JEV) infection-driven changes in the mouse embryonic fibroblast (MEF) proteome. ...Further, many interferon-stimulated g …
Advances in proteomics have enabled a comprehensive understanding of host-pathogen interactions. Here we have characterized Japanese encepha …
Interaction of Ectodomain of Respiratory Syncytial Virus G Protein with TLR2/ TLR6 Heterodimer: An In vitro and In silico Approach to Decipher the Role of RSV G Protein in Pro-inflammatory Response against the Virus.
Alshaghdali K, Saeed M, Kamal MA, Saeed A. Alshaghdali K, et al. Curr Pharm Des. 2021;27(44):4464-4476. doi: 10.2174/1381612827666210716160030. Curr Pharm Des. 2021. PMID: 34279194
Various inflammatory cytokines, chemokines and type I IFNs were measured by ELISA along with their mRNA expression by qPCR. In silico interaction of RSV G protein with TLR2/TLR6 was also analyzed. RESULTS: Results of ELISA and qPCR analysis have shown that TLR2/TLR6 …
Various inflammatory cytokines, chemokines and type I IFNs were measured by ELISA along with their mRNA expression by qPCR. In silico intera …
1,015 results