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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1999 1
2000 2
2001 3
2002 6
2003 16
2004 15
2005 25
2006 34
2007 29
2008 35
2009 47
2010 61
2011 44
2012 39
2013 57
2014 44
2015 53
2016 47
2017 35
2018 43
2019 55
2020 58
2021 25
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683 results
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Page 1
Multiple sclerosis, the microbiome, TLR2, and the hygiene hypothesis.
Wasko NJ, Nichols F, Clark RB. Wasko NJ, et al. Autoimmun Rev. 2020 Jan;19(1):102430. doi: 10.1016/j.autrev.2019.102430. Epub 2019 Nov 15. Autoimmun Rev. 2020. PMID: 31734400 Free article. Review.
Our central hypothesis is that the microbiome in MS represents a "defective environment" that fails to provide normal levels of "TLR2-tolerizing" bacterial products to the systemic immune system. ...We have completed proof of concept studies that support the inflamm …
Our central hypothesis is that the microbiome in MS represents a "defective environment" that fails to provide normal levels of "TLR2
Combination of TLR2 and TLR3 agonists derepress infectious bursal disease virus vaccine-induced immunosuppression in the chicken.
Bashir K, Kappala D, Singh Y, Dar JA, Mariappan AK, Kumar A, Krishnaswamy N, Dey S, Chellappa MM, Goswami TK, Gupta VK, Ramakrishnan S. Bashir K, et al. Sci Rep. 2019 Jun 3;9(1):8197. doi: 10.1038/s41598-019-44578-5. Sci Rep. 2019. PMID: 31160675 Free PMC article.
We evaluated the potential of Toll-like receptor (TLR) agonists to alleviate hot vaccine-induced immunosuppression. The combination of Pam3CSK4 and poly I:C synergistically upregulated IFN-beta, IFN-gamma, IL-12, IL-4, and IL-13 transcripts and cross-inhibited IL-1beta, IL …
We evaluated the potential of Toll-like receptor (TLR) agonists to alleviate hot vaccine-induced immunosuppression. The combination o …
HMGB1 and RAGE in inflammation and cancer.
Sims GP, Rowe DC, Rietdijk ST, Herbst R, Coyle AJ. Sims GP, et al. Annu Rev Immunol. 2010;28:367-88. doi: 10.1146/annurev.immunol.021908.132603. Annu Rev Immunol. 2010. PMID: 20192808 Review.
The immune system has evolved to respond not only to pathogens, but also to signals released from dying cells. ...HMGB1 can associate with other molecules, including TLR ligands and cytokines, and activates cells through the differential engagement of multiple surface rece …
The immune system has evolved to respond not only to pathogens, but also to signals released from dying cells. ...HMGB1 can associate …
Tumor-released autophagosomes induces CD4(+) T cell-mediated immunosuppression via a TLR2-IL-6 cascade.
Chen YQ, Li PC, Pan N, Gao R, Wen ZF, Zhang TY, Huang F, Wu FY, Ou XL, Zhang JP, Zhu XJ, Hu HM, Chen K, Cai YL, Wang LX. Chen YQ, et al. J Immunother Cancer. 2019 Jul 12;7(1):178. doi: 10.1186/s40425-019-0646-5. J Immunother Cancer. 2019. PMID: 31300052 Free PMC article.
CONCLUSIONS: HSP90alpha on the surface of TRAPs programs the immunosuppressive functions of CD4(+) T cells to promote tumor growth and metastasis. TRAPs or their membrane-bound HSP90alpha represent important therapeutic targets to reverse cancer-associated immunosuppres
CONCLUSIONS: HSP90alpha on the surface of TRAPs programs the immunosuppressive functions of CD4(+) T cells to promote tumor growth an …
Regulatory B cells in infection, inflammation, and autoimmunity.
Dasgupta S, Dasgupta S, Bandyopadhyay M. Dasgupta S, et al. Cell Immunol. 2020 Jun;352:104076. doi: 10.1016/j.cellimm.2020.104076. Epub 2020 Feb 27. Cell Immunol. 2020. PMID: 32143836 Review.
Breg cells produce IL10 and IL35 and to cause immunosuppression. These cells respond to TLR2, TLR4, and TLR9 agonists, CD40 ligands, IL12p35 and heat shock proteins. ...However, the Breg-mediated mechanism used to control T cell-mediated immune responses is s …
Breg cells produce IL10 and IL35 and to cause immunosuppression. These cells respond to TLR2, TLR4, and TLR9 agonists, CD40 li …
Immune Dysfunction and Albumin-Related Immunity in Liver Cirrhosis.
Wilde B, Katsounas A. Wilde B, et al. Mediators Inflamm. 2019 Feb 25;2019:7537649. doi: 10.1155/2019/7537649. eCollection 2019. Mediators Inflamm. 2019. PMID: 30930689 Free PMC article. Review.
Bacterial translocation supports-and is supported by-uncontrolled activation of immune cell responses and/or loss of toll-like receptor (TLR) tolerance, which can turn exaggerated inflammatory responses to systemic inflammation. ...To date, there is no data availabl …
Bacterial translocation supports-and is supported by-uncontrolled activation of immune cell responses and/or loss of toll-like recept …
Xinjiang herbal tea exerts immunomodulatory activity via TLR2/4-mediated MAPK signaling pathways in RAW264.7 cells and prevents cyclophosphamide-induced immunosuppression in mice.
Bai Y, Jiang Y, Liu T, Li F, Zhang J, Luo Y, Zhang L, Yan G, Feng Z, Li X, Wang X, Hu W. Bai Y, et al. J Ethnopharmacol. 2019 Jan 10;228:179-187. doi: 10.1016/j.jep.2018.09.032. Epub 2018 Sep 27. J Ethnopharmacol. 2019. PMID: 30268651
ETHNOPHARMACOLOGICAL RELEVANCE: A multi-herb Chinese medicinal formula consisting of a variety of medicinal and edible materials has long been consumed as a hot drink and immune enhancer for its efficiency to increase disease resistance in Xinjiang, China. ...Moreover, XMT …
ETHNOPHARMACOLOGICAL RELEVANCE: A multi-herb Chinese medicinal formula consisting of a variety of medicinal and edible materials has long be …
Toll-Like Receptor Agonists as Adjuvants for Allergen Immunotherapy.
Kirtland ME, Tsitoura DC, Durham SR, Shamji MH. Kirtland ME, et al. Front Immunol. 2020 Nov 12;11:599083. doi: 10.3389/fimmu.2020.599083. eCollection 2020. Front Immunol. 2020. PMID: 33281825 Free PMC article. Review.
TLR activation on dendritic cells can propagate to an adaptive immune response, making them attractive targets for the development of both prophylactic and therapeutic vaccines. ...Synthetic TLR4, and TLR9 agonists have progressed to clinical trials, while TLR2, TLR …
TLR activation on dendritic cells can propagate to an adaptive immune response, making them attractive targets for the development of …
TLR2 and endosomal TLR-mediated secretion of IL-10 and immune suppression in response to phagosome-confined Listeria monocytogenes.
Nguyen BN, Chávez-Arroyo A, Cheng MI, Krasilnikov M, Louie A, Portnoy DA. Nguyen BN, et al. PLoS Pathog. 2020 Jul 7;16(7):e1008622. doi: 10.1371/journal.ppat.1008622. eCollection 2020 Jul. PLoS Pathog. 2020. PMID: 32634175 Free PMC article.
Secretion of IL-10 in response to infection with the parental strain was mostly TLR2-dependent, while IL-10 secretion in response to lysozyme-sensitive strains was dependent on TLR2 and Unc93b1. ...These data revealed that secretion of IL-10 in response to L. monocy …
Secretion of IL-10 in response to infection with the parental strain was mostly TLR2-dependent, while IL-10 secretion in response to …
Expression of Toll-Like Receptors (TLR2 and TLR4) in the Eyes of Mice with Disseminated Acanthamoebiasis.
Kot K, Kosik-Bogacka D, Łanocha-Arendarczyk N, Wojtkowiak-Giera A, Kolasa-Wołosiuk A. Kot K, et al. Biomed Res Int. 2019 Jun 12;2019:1401894. doi: 10.1155/2019/1401894. eCollection 2019. Biomed Res Int. 2019. PMID: 31309100 Free PMC article.
Immunosuppressed mice showed significant differences in the expression of TLR2 at 16 and 24 dpi compared to uninfected animals. ...The course of disseminated acanthamoebiasis may be influenced by the host's immunological status, and the observed changes in ex
Immunosuppressed mice showed significant differences in the expression of TLR2 at 16 and 24 dpi compared to uninfected animals
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