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248 results

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Page 1
Emerging Targets to Relieve Fat Stress-Induced Liver Diseases: UDCA, Tocotrienol, omega-3 PUFAs, and IgY Targeted NPC1L1 Cholesterol Transporter.
Cha JY, Park JM, Lee HJ, Bae JS, Han YM, Oh BC, Ko KH, Hahm KB. Cha JY, et al. Curr Pharm Des. 2017;23(27):3941-3951. doi: 10.2174/1381612823666170714124824. Curr Pharm Des. 2017. PMID: 28714405 Review.
These include an NPC1L1 blocker (ezetimibe), which significantly improved histological and symptomatic scores associated with steatohepatitis and fibrosis; clofibrate, phentoxyfylline, ursodeoxycholic acid, and tocopherol, all of which are prescribed to relieve fat stress; and ad …
These include an NPC1L1 blocker (ezetimibe), which significantly improved histological and symptomatic scores associated with steatohepatiti …
Tocotrienol and Its Role in Chronic Diseases.
Chin KY, Pang KL, Soelaiman IN. Chin KY, et al. Adv Exp Med Biol. 2016;928:97-130. doi: 10.1007/978-3-319-41334-1_5. Adv Exp Med Biol. 2016. PMID: 27671814 Review.
It is also a suppressor of mevalonate pathway responsible for cholesterol and prenylated protein synthesis. This review aimed to discuss the health beneficial effects of tocotrienol, specifically in preventing or treating hyperlipidaemia, diabetes mellitus, osteopor …
It is also a suppressor of mevalonate pathway responsible for cholesterol and prenylated protein synthesis. This review aimed to disc …
A Review on the Relationship between Tocotrienol and Alzheimer Disease.
Chin KY, Tay SS. Chin KY, et al. Nutrients. 2018 Jul 9;10(7):881. doi: 10.3390/nu10070881. Nutrients. 2018. PMID: 29987193 Free PMC article. Review.
Development of agents targeting specific pathologies of AD is very slow. Tocotrienol, a member of the vitamin E family, can tackle many aspects of AD, such as oxidative stress, mitochondrial dysfunction and abnormal cholesterol synthesis. ...Human epidemiological st …
Development of agents targeting specific pathologies of AD is very slow. Tocotrienol, a member of the vitamin E family, can tackle ma …
Tocotrienols in cardioprotection.
Das S, Nesaretnam K, Das DK. Das S, et al. Vitam Horm. 2007;76:419-33. doi: 10.1016/S0083-6729(07)76016-8. Vitam Horm. 2007. PMID: 17628184 Review.
Tocotrienols, a group of Vitamin E stereoisomers, offer many health benefits including their ability to lower cholesterol levels, and provide anticancer and tumor-suppressive activities. ...Hence, tocotrienols likely fulfills the definition of a pharmacologic …
Tocotrienols, a group of Vitamin E stereoisomers, offer many health benefits including their ability to lower cholesterol leve …
The mevalonate suppressor delta-tocotrienol increases AMPA receptor-mediated neurotransmission.
Wei W, Yount ST, Allen ZD, Bechdol KF, Xia W, Mo H, Mabb AM. Wei W, et al. Biochem Biophys Res Commun. 2023 Jan 1;638:112-119. doi: 10.1016/j.bbrc.2022.11.052. Epub 2022 Nov 20. Biochem Biophys Res Commun. 2023. PMID: 36446153
Tocotrienols have also been shown to reduce the secretion of beta-amyloid (Abeta) and cholesterol biosynthesis in part by downregulating 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase, the rate-limiting enzyme that controls flux of the mevalonate pathway …
Tocotrienols have also been shown to reduce the secretion of beta-amyloid (Abeta) and cholesterol biosynthesis in part by down …
Minor bioactive lipids.
Tsimidou MZ, Mantzouridou FT, Nenadis N. Tsimidou MZ, et al. Adv Food Nutr Res. 2023;105:51-95. doi: 10.1016/bs.afnr.2022.11.003. Epub 2023 Feb 6. Adv Food Nutr Res. 2023. PMID: 37516468
Their interactions with other food ingredients are critical because of their role against reactive oxygen species. The role of cholesterol through the diet after decades of disputes is better justified whereas at the same time emphasis is given to the technological and hea …
Their interactions with other food ingredients are critical because of their role against reactive oxygen species. The role of cholestero …
Cereal grains, alpha tocotrienol and cholesterol metabolism in the rat.
McIntosh GH, Bulman FH, Russell GR. McIntosh GH, et al. Asia Pac J Clin Nutr. 1992 Jun;1(2):89-94. Asia Pac J Clin Nutr. 1992. PMID: 24323085 Free article.
Both oats and barley lowered plasma cholesterol relative lo wheat, which had no such effect, and the change has been attributed to an inhibitory influence of a -tocotrienol on cholesterol synthesis rate. ...There was no significant influence on plasma chol …
Both oats and barley lowered plasma cholesterol relative lo wheat, which had no such effect, and the change has been attributed to an …
The 21st century form of vitamin E--tocotrienol.
Bardhan J, Chakraborty R, Raychaudhuri U. Bardhan J, et al. Curr Pharm Des. 2011;17(21):2196-205. doi: 10.2174/138161211796957472. Curr Pharm Des. 2011. PMID: 21774783 Review.
Research shows that tocotrienol can inhibit the induced oxidative damage to lipids and proteins. Cholesterol biosynthesis pathway requires HMG Co A reductase. Tocotrienol degrades HMG Co A reductase protein and in turn lowers cholesterol synthesis. ...
Research shows that tocotrienol can inhibit the induced oxidative damage to lipids and proteins. Cholesterol biosynthesis path …
Tocotrienol Affects Oxidative Stress, Cholesterol Homeostasis and the Amyloidogenic Pathway in Neuroblastoma Cells: Consequences for Alzheimer's Disease.
Grimm MO, Regner L, Mett J, Stahlmann CP, Schorr P, Nelke C, Streidenberger O, Stoetzel H, Winkler J, Zaidan SR, Thiel A, Endres K, Grimm HS, Volmer DA, Hartmann T. Grimm MO, et al. Int J Mol Sci. 2016 Oct 29;17(11):1809. doi: 10.3390/ijms17111809. Int J Mol Sci. 2016. PMID: 27801864 Free PMC article.
In line with the literature, alpha-tocotrienol reduced the ROS level in SH-SY5Y cells. In the presence of tocotrienols, cholesterol and cholesterol esters, which have been shown to be risk factors in AD, were decreased. ...Proteins and gene expression …
In line with the literature, alpha-tocotrienol reduced the ROS level in SH-SY5Y cells. In the presence of tocotrienols, cho …
Comparative efficacy of tocotrienol and tocopherol (vitamin E) on atherosclerotic cardiovascular diseases in humans.
Rafique S, Khan DA, Farhat K, Khan MA, Noor M, Sharif M. Rafique S, et al. J Pak Med Assoc. 2024 Jun;74(6):1124-1129. doi: 10.47391/JPMA.9227. J Pak Med Assoc. 2024. PMID: 38948984 Free article.
OBJECTIVE: To compare the efficacy of tocotrienol and tocopherol in the management of patients with atherosclerotic cardiovascular diseases. ...Of them 5(19%) were subjected to detailed analysis. Tocotrienol showed significant anti-oxidant efficacy at (250 mg/d) by …
OBJECTIVE: To compare the efficacy of tocotrienol and tocopherol in the management of patients with atherosclerotic cardiovascular di …
248 results