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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1945 4
1946 30
1947 34
1948 14
1949 32
1950 59
1951 133
1952 143
1953 145
1954 139
1955 94
1956 117
1957 122
1958 104
1959 106
1960 112
1961 95
1962 110
1963 118
1964 131
1965 131
1966 99
1967 110
1968 125
1969 162
1970 141
1971 189
1972 227
1973 465
1974 665
1975 704
1976 678
1977 604
1978 629
1979 660
1980 625
1981 623
1982 741
1983 809
1984 912
1985 1053
1986 1084
1987 1269
1988 1300
1989 1554
1990 1640
1991 1662
1992 1728
1993 1658
1994 1803
1995 1908
1996 2028
1997 2292
1998 2268
1999 2385
2000 2481
2001 2769
2002 2850
2003 3120
2004 3117
2005 3301
2006 3504
2007 3674
2008 3763
2009 4015
2010 4139
2011 4040
2012 4250
2013 4307
2014 4505
2015 4605
2016 4946
2017 4927
2018 4793
2019 4879
2020 4699
2021 3868
2022 2715
2023 2484
2024 4060
2025 768

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122,196 results

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Page 1
Delivery of biologics: Topical administration.
Kulchar RJ, Singh R, Ding S, Alexander E, Leong KW, Daniell H. Kulchar RJ, et al. Biomaterials. 2023 Nov;302:122312. doi: 10.1016/j.biomaterials.2023.122312. Epub 2023 Sep 4. Biomaterials. 2023. PMID: 37690380 Free PMC article. Review.
In addition, the cost of developing a new biologic injectable product ($2.5 billion) has been dramatically reduced through oral or topical delivery. Topical delivery has the unique advantage of targeted delivery of high concentration protein drugs, without getting d …
In addition, the cost of developing a new biologic injectable product ($2.5 billion) has been dramatically reduced through oral or topica …
Safety of topical administration of nasal decongestants and vasoconstrictors in paediatric nasal surgery - A systematic review.
Macmillan AJ, Phoon KM, Edafe O. Macmillan AJ, et al. Int J Pediatr Otorhinolaryngol. 2022 Feb;153:111010. doi: 10.1016/j.ijporl.2021.111010. Epub 2021 Dec 17. Int J Pediatr Otorhinolaryngol. 2022. PMID: 34942425
OBJECTIVES: Topical intranasal decongestants are essential in nasal surgery to improve operative field. ...
OBJECTIVES: Topical intranasal decongestants are essential in nasal surgery to improve operative field. ...
Ocular Drug Delivery: a Comprehensive Review.
Ahmed S, Amin MM, Sayed S. Ahmed S, et al. AAPS PharmSciTech. 2023 Feb 14;24(2):66. doi: 10.1208/s12249-023-02516-9. AAPS PharmSciTech. 2023. PMID: 36788150 Review.
The human eye is a sophisticated organ with distinctive anatomy and physiology that hinders the passage of drugs into targeted ophthalmic sites. Effective topical administration is an interest of scientists for many decades. Their difficult mission is to prolong dru …
The human eye is a sophisticated organ with distinctive anatomy and physiology that hinders the passage of drugs into targeted ophthalmic si …
Enhancing topical analgesic administration: review and prospect for transdermal and transbuccal drug delivery systems.
Sanz R, Calpena AC, Mallandrich M, Clares B. Sanz R, et al. Curr Pharm Des. 2015;21(20):2867-82. doi: 10.2174/1381612821666150428145627. Curr Pharm Des. 2015. PMID: 25925112 Review.
However, topical administration must overcome the permeable barriers that skin and mucosa represent for the drug to achieve its desired therapeutic effect. ...As analgesia is one of the main therapeutic effects sought through topical administration, th …
However, topical administration must overcome the permeable barriers that skin and mucosa represent for the drug to achieve it …
Lipid vesicular gels for topical administration of antioxidants.
Fornasier M, Dessì F, Pireddu R, Sinico C, Carretti E, Murgia S. Fornasier M, et al. Colloids Surf B Biointerfaces. 2022 May;213:112388. doi: 10.1016/j.colsurfb.2022.112388. Epub 2022 Feb 2. Colloids Surf B Biointerfaces. 2022. PMID: 35183999
These gels were then tested in vitro on new-born pig skin to evaluate their efficacy as drug carriers for topical administration, showing that caffeic acid is mostly retained in the gel whereas ferulic acid is released at a higher degree. The data herein reported pr …
These gels were then tested in vitro on new-born pig skin to evaluate their efficacy as drug carriers for topical administration …
Topical Administration of Verapamil in Poly(ethylene glycol)-Modified Liposomes for Enhanced Sinonasal Tissue Residence in Chronic Rhinosinusitis: Ex Vivo and In Vivo Evaluations.
Taha MS, Kutlehria S, D'Souza A, Bleier BS, Amiji MM. Taha MS, et al. Mol Pharm. 2023 Mar 6;20(3):1729-1736. doi: 10.1021/acs.molpharmaceut.2c00943. Epub 2023 Feb 6. Mol Pharm. 2023. PMID: 36744718 Free PMC article.
The verapamil-induced side effects limit its tolerated dose via the oral route, underscoring the usefulness of localized intranasal administration. However, the challenge to intranasal administration is mucociliary clearance, which diminishes localized dose availabi …
The verapamil-induced side effects limit its tolerated dose via the oral route, underscoring the usefulness of localized intranasal admin …
Topical Ocular Therapeutics in Small Animals.
James-Jenks EM, Pinard CL. James-Jenks EM, et al. Vet Clin North Am Small Anim Pract. 2023 Mar;53(2):473-492. doi: 10.1016/j.cvsm.2022.10.008. Vet Clin North Am Small Anim Pract. 2023. PMID: 36813396 Review.
This article reviews the administration of common topical ophthalmic medications, in relation to factors influencing absorption including composition of topical ophthalmic preparations, and potential systemic effects. ...Knowledge of topical ocular pha …
This article reviews the administration of common topical ophthalmic medications, in relation to factors influencing absorptio …
A new topical.
Balak DMW, Hajdarbegovic E. Balak DMW, et al. Br J Dermatol. 2022 Jan;186(1):5-6. doi: 10.1111/bjd.20817. Epub 2021 Nov 2. Br J Dermatol. 2022. PMID: 34726775 No abstract available.
Topical Vehicles: A Dermatologist's Perspective.
Adame S, Collins ME, Korman AM. Adame S, et al. Int J Pharm Compd. 2023 Jul-Aug;27(4):278-283. Int J Pharm Compd. 2023. PMID: 37595171 Review.
Topical treatment is mainstay for a variety of dermatologic conditions. There are several different types of topical vehicles, and choosing the most appropriate one is an essential part of treatment. ...This article reviews some of the most common topical veh …
Topical treatment is mainstay for a variety of dermatologic conditions. There are several different types of topical vehicles, …
Topical administration of S. salivarius 24SMB-S. oralis 89a in children with adenoidal disease: a double-blind controlled trial.
Folino F, Di Pasquale D, Marchisio P, Pignataro L, Capaccio P, Gaini L, Battilocchi L, Bosis S, Torretta S. Folino F, et al. Eur J Pediatr. 2024 Jan;183(1):289-294. doi: 10.1007/s00431-023-05192-w. Epub 2023 Oct 24. Eur J Pediatr. 2024. PMID: 37874401 Free PMC article. Clinical Trial.
The aim of this study was to assess the efficacy and safety of the topical nasal administration of a probiotic compound based on S. salivarius 24SMB and S. oralis 89a in children with CA in terms of reduction in: the number of acute adenoidal infections (primary out …
The aim of this study was to assess the efficacy and safety of the topical nasal administration of a probiotic compound based …
122,196 results
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