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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1795 1
1797 1
1822 1
1826 2
1827 1
1831 3
1842 1
1849 5
1850 2
1851 1
1852 1
1853 1
1854 1
1855 1
1856 2
1857 2
1858 1
1860 1
1862 1
1866 3
1869 1
1870 2
1871 3
1873 1
1876 1
1877 1
1878 1
1881 1
1882 2
1885 3
1886 1
1888 2
1890 1
1894 1
1896 1
1897 2
1899 2
1905 1
1906 1
1907 2
1909 2
1910 2
1911 2
1912 1
1913 1
1915 2
1917 1
1918 2
1919 3
1920 3
1921 2
1922 1
1923 1
1925 2
1926 1
1927 3
1928 2
1930 1
1931 2
1933 2
1934 4
1935 1
1936 1
1938 3
1939 1
1940 1
1941 9
1942 3
1944 2
1945 19
1946 23
1947 20
1948 32
1949 39
1950 45
1951 63
1952 49
1953 52
1954 51
1955 40
1956 30
1957 38
1958 44
1959 39
1960 28
1961 33
1962 31
1963 39
1964 55
1965 54
1966 89
1967 80
1968 88
1969 85
1970 100
1971 99
1972 83
1973 84
1974 99
1975 425
1976 437
1977 458
1978 393
1979 435
1980 494
1981 541
1982 569
1983 690
1984 805
1985 863
1986 787
1987 834
1988 871
1989 1231
1990 1249
1991 1286
1992 1241
1993 1262
1994 1380
1995 1553
1996 1724
1997 1798
1998 1915
1999 2022
2000 2142
2001 2274
2002 2417
2003 2523
2004 2914
2005 3326
2006 3583
2007 3677
2008 3992
2009 4241
2010 4530
2011 5079
2012 5540
2013 6092
2014 6654
2015 6991
2016 7584
2017 7978
2018 8726
2019 9120
2020 10614
2021 11903
2022 12648
2023 12673
2024 14640
2025 5719

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177,488 results

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Page 1
The multiple uses of azelaic acid in dermatology: mechanism of action, preparations, and potential therapeutic applications.
Sauer N, Oślizło M, Brzostek M, Wolska J, Lubaszka K, Karłowicz-Bodalska K. Sauer N, et al. Postepy Dermatol Alergol. 2023 Dec;40(6):716-724. doi: 10.5114/ada.2023.133955. Epub 2024 Jan 8. Postepy Dermatol Alergol. 2023. PMID: 38282869 Free PMC article. Review.
Azelaic acid (AZA) is a naturally occurring saturated dicarboxylic acid whose topical application has found multiple uses in dermatology. Its anti-inflammatory, antioxidant and antimicrobial properties against Propionibacterium acne are currently used in the treatme …
Azelaic acid (AZA) is a naturally occurring saturated dicarboxylic acid whose topical application has found multiple uses in d …
Topical (local) antibiotics for respiratory infections with sore throat: An antibiotic stewardship perspective.
Essack S, Bell J, Burgoyne DS, Duerden M, Shephard A. Essack S, et al. J Clin Pharm Ther. 2019 Dec;44(6):829-837. doi: 10.1111/jcpt.13012. Epub 2019 Aug 13. J Clin Pharm Ther. 2019. PMID: 31407824 Free PMC article. Review.
The objective of this systematic review was to establish the evidence for the benefits, risk of harm and antimicrobial resistance associated with topical (local) antibiotics used for patients with sore throat. METHODS: Eligible studies included those in patients wit …
The objective of this systematic review was to establish the evidence for the benefits, risk of harm and antimicrobial resistance associated …
Advances in Psoriasis.
Smith J, Cline A, Feldman SR. Smith J, et al. South Med J. 2017 Jan;110(1):65-75. doi: 10.14423/SMJ.0000000000000596. South Med J. 2017. PMID: 28052180 Review.
Psoriasis treatments range from topical treatments and phototherapy to oral systemic medications and injections. Despite good control of the disease when applying appropriate treatments (according to disease severity, insurance parameters, patient preference, and patients' …
Psoriasis treatments range from topical treatments and phototherapy to oral systemic medications and injections. Despite good control …
Polyaphron Dispersion Technology, A Novel Topical Formulation and Delivery System Combining Drug Penetration, Local Tolerability and Convenience of Application.
Praestegaard M, Steele F, Crutchley N. Praestegaard M, et al. Dermatol Ther (Heidelb). 2022 Oct;12(10):2217-2231. doi: 10.1007/s13555-022-00794-y. Epub 2022 Sep 1. Dermatol Ther (Heidelb). 2022. PMID: 36050567 Free PMC article. Review.
Topical formulation and delivery technologies for pharmaceutical application should simultaneously address efficacy, safety and convenience of therapy. ...In this regard, a key benefit of PAD formulations is the inherent reduced requirement for surfactants to genera
Topical formulation and delivery technologies for pharmaceutical application should simultaneously address efficacy, safety an
Topical application of Porphyromonas gingivalis into the gingival pocket in mice leads to chronic-active infection, periodontitis and systemic inflammation.
Kim S, Bando Y, Chang C, Kwon J, Tarverti B, Kim D, Lee SH, Ton-That H, Kim R, Nara PL, Park NH. Kim S, et al. Int J Mol Med. 2022 Aug;50(2):103. doi: 10.3892/ijmm.2022.5159. Epub 2022 Jun 15. Int J Mol Med. 2022. PMID: 35703359 Free PMC article.
In order to achieve a more realistic animal model of human Pg infection, the present study investigated whether repeated small-volume topical applications of Pg directly into the gingival pocket can induce local infection, including periodontitis and systemic …
In order to achieve a more realistic animal model of human Pg infection, the present study investigated whether repeated small-volume top
New paradigms on siRNA local application.
Pan M, Ni J, He H, Gao S, Duan X. Pan M, et al. BMB Rep. 2015 Mar;48(3):147-52. doi: 10.5483/bmbrep.2015.48.3.089. BMB Rep. 2015. PMID: 25081998 Free PMC article.
Here, we reviewed recently published data regarding local applications of siRNA. Compared with systemic delivery methods, local delivery of siRNA/shRNA has many advantages, such as targeting the specific tissues or organs, mimicking a gene knockout effect, or …
Here, we reviewed recently published data regarding local applications of siRNA. Compared with systemic delivery methods, l
Drug delivery systems for oral disease applications.
Zhang Y, Jiang R, Lei L, Yang Y, Hu T. Zhang Y, et al. J Appl Oral Sci. 2022 Mar 9;30:e20210349. doi: 10.1590/1678-7757-2021-0349. eCollection 2022. J Appl Oral Sci. 2022. PMID: 35262595 Free PMC article. Review.
There are many restrictions on topical medications for the oral cavity. Various factors affect the topical application of drugs in the oral cavity, an open and complex environment. ...We discuss synthesis methods and their application scope to provide …
There are many restrictions on topical medications for the oral cavity. Various factors affect the topical application
Influence of topical application of capsaicin, menthol and local anesthetics on intraoral somatosensory sensitivity in healthy subjects: temporal and spatial aspects.
Naganawa T, Baad-Hansen L, Ando T, Svensson P. Naganawa T, et al. Exp Brain Res. 2015 Apr;233(4):1189-99. doi: 10.1007/s00221-015-4200-5. Epub 2015 Jan 18. Exp Brain Res. 2015. PMID: 25596697
The aim of this study was to investigate temporal and spatial aspects of somatosensory changes after topical application of capsaicin, menthol and local anesthetics (LA) on the gingiva with the use of intraoral palpometers and thermal devices. ...Standardized …
The aim of this study was to investigate temporal and spatial aspects of somatosensory changes after topical application of ca …
Emollients: application of topical treatments to the skin.
Dunning G. Dunning G. Br J Nurs. 2007 Nov 22-Dec 12;16(21):1342-5. doi: 10.12968/bjon.2007.16.21.27723. Br J Nurs. 2007. PMID: 18073674 Review.
Nurses working in various clinical settings can make a real difference to the clinical effectiveness of topical applications to the skin by increasing their knowledge of the choice and mechanisms involved. ...This article focuses on increasing the reader's knowledge …
Nurses working in various clinical settings can make a real difference to the clinical effectiveness of topical applications t …
CMOS electrochemical pH localizer-imager.
Jung HS, Jung WB, Wang J, Abbott J, Horgan A, Fournier M, Hinton H, Hwang YH, Godron X, Nicol R, Park H, Ham D. Jung HS, et al. Sci Adv. 2022 Jul 29;8(30):eabm6815. doi: 10.1126/sciadv.abm6815. Epub 2022 Jul 27. Sci Adv. 2022. PMID: 35895813 Free PMC article.
Densely arrayed pH microenvironments would parallelize these processes, enabling their high-throughput studies and applications. However, pH localization, let alone its arrayed realization, remains challenging because of fast diffusion of protons in water. ...We hig …
Densely arrayed pH microenvironments would parallelize these processes, enabling their high-throughput studies and applications. Howe …
177,488 results
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