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164 results

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Page 1
Topical Diclofenac, an Efficacious Treatment for Osteoarthritis: A Narrative Review.
Bariguian Revel F, Fayet M, Hagen M. Bariguian Revel F, et al. Rheumatol Ther. 2020 Jun;7(2):217-236. doi: 10.1007/s40744-020-00196-6. Epub 2020 Feb 21. Rheumatol Ther. 2020. PMID: 32086778 Free PMC article. Review.
Multiple head-to-head trials have demonstrated that topical nonsteroidal anti-inflammatory drugs (NSAIDs), including topical diclofenac, provide at least equivalent analgesia, improvement in physical function, and reduction of stiffness compared with oral NSA …
Multiple head-to-head trials have demonstrated that topical nonsteroidal anti-inflammatory drugs (NSAIDs), including topical …
Efficacy and safety of different topical diclofenac formulations for the treatment of knee osteoarthritis: a meta-analysis of short-term and long-term treatment comparisons.
Chen ZR, Chen BK, Li P, Feng K. Chen ZR, et al. BMC Musculoskelet Disord. 2025 Mar 10;26(1):230. doi: 10.1186/s12891-025-08465-7. BMC Musculoskelet Disord. 2025. PMID: 40065343 Free PMC article.
OBJECTIVE: This meta-analysis evaluates the efficacy and safety of various topical dosage forms of diclofenac (gel, solution, and patch) for the treatment of knee osteoarthritis. ...The overall quality of evidence was assessed as moderate to high, reinforcing …
OBJECTIVE: This meta-analysis evaluates the efficacy and safety of various topical dosage forms of diclofenac (gel, solution, …
Topical Diclofenac Solution for Osteoarthritis of the Knee: An Updated Meta-Analysis of Randomized Controlled Trials.
Ling T, Li JJ, Xu RJ, Wang B, Ge WH. Ling T, et al. Biomed Res Int. 2020 Nov 24;2020:1758071. doi: 10.1155/2020/1758071. eCollection 2020. Biomed Res Int. 2020. PMID: 33299860 Free PMC article.
This study was performed to assess the efficacy and safety of a topical diclofenac solution in patients with knee osteoarthritis (OA). PubMed, Embase, Cochrane Library, Web of Science, and Scopus databases were searched for randomized controlled trials until …
This study was performed to assess the efficacy and safety of a topical diclofenac solution in patients with knee osteoarth …
Oral Versus Topical Diclofenac Sodium in the Treatment of Osteoarthritis.
Tieppo Francio V, Davani S, Towery C, Brown TL. Tieppo Francio V, et al. J Pain Palliat Care Pharmacother. 2017 Jun;31(2):113-120. doi: 10.1080/15360288.2017.1301616. Epub 2017 Apr 7. J Pain Palliat Care Pharmacother. 2017. PMID: 28388238 Review.
Osteoarthritis (OA) is one of the most common causes of joint pain in the United States and non-steroidal anti-inflammatories (NSAIDs), such as Diclofenac sodium, which is currently available in two main routes of administration; oral and topical distribution …
Osteoarthritis (OA) is one of the most common causes of joint pain in the United States and non-steroidal anti-inflammatories (NSAIDs …
Topical diclofenac therapy for osteoarthritis: a meta-analysis of randomized controlled trials.
Deng ZH, Zeng C, Yang Y, Li YS, Wei J, Yang T, Li H, Lei GH. Deng ZH, et al. Clin Rheumatol. 2016 May;35(5):1253-61. doi: 10.1007/s10067-015-3021-z. Epub 2015 Aug 5. Clin Rheumatol. 2016. PMID: 26242469
The objective of this study was to evaluate the efficacy and safety of topical diclofenac therapy for osteoarthritis (OA). A meta-analysis of randomized controlled trials was conducted. ...Although, some adverse effects were observed in the application of …
The objective of this study was to evaluate the efficacy and safety of topical diclofenac therapy for osteoarthritis (O …
Topical Diclofenac-Induced Hepatotoxicity.
Delungahawatta T, Pokharel A, Paz R, Haas CJ. Delungahawatta T, et al. J Community Hosp Intern Med Perspect. 2023 May 8;13(3):108-112. doi: 10.55729/2000-9666.1190. eCollection 2023. J Community Hosp Intern Med Perspect. 2023. PMID: 37877052 Free PMC article.
We report the case of an elderly man with Paget's disease and osteoarthritis who developed acute hepatotoxicity, as evidenced by laboratory diagnostics, four months after use of topical diclofenac 1% gel. ...Further research on topically administered n …
We report the case of an elderly man with Paget's disease and osteoarthritis who developed acute hepatotoxicity, as evidenced by labo …
The use of topical diclofenac for pain in osteoarthritis of the knee: a review.
Banning M. Banning M. Br J Community Nurs. 2006 Nov;11(11):487-92. doi: 10.12968/bjcn.2006.11.11.22278. Br J Community Nurs. 2006. PMID: 17170650 Review.
The use of a topical formulation of diclofenac sodium aims to reduce this problem. Evidence from four randomized controlled trails of the efficacy and safety of topical diclofenac sodium as a method of pain relief for the treatment of OA of the knee is …
The use of a topical formulation of diclofenac sodium aims to reduce this problem. Evidence from four randomized controlled tr …
Effectiveness and safety of non-steroidal anti-inflammatory drugs and opioid treatment for knee and hip osteoarthritis: network meta-analysis.
da Costa BR, Pereira TV, Saadat P, Rudnicki M, Iskander SM, Bodmer NS, Bobos P, Gao L, Kiyomoto HD, Montezuma T, Almeida MO, Cheng PS, Hincapié CA, Hari R, Sutton AJ, Tugwell P, Hawker GA, Jüni P. da Costa BR, et al. BMJ. 2021 Oct 12;375:n2321. doi: 10.1136/bmj.n2321. BMJ. 2021. PMID: 34642179 Free PMC article.
CONCLUSIONS: Etoricoxib 60 mg/day and diclofenac 150 mg/day seem to be the most effective oral NSAIDs for pain and function in patients with osteoarthritis. ...Additionally, an increased risk of dropping out due to adverse events was found for diclofenac 150 …
CONCLUSIONS: Etoricoxib 60 mg/day and diclofenac 150 mg/day seem to be the most effective oral NSAIDs for pain and function in patien …
Advanced application of stimuli-responsive drug delivery system for inflammatory arthritis treatment.
Zhang M, Hu W, Cai C, Wu Y, Li J, Dong S. Zhang M, et al. Mater Today Bio. 2022 Feb 21;14:100223. doi: 10.1016/j.mtbio.2022.100223. eCollection 2022 Mar. Mater Today Bio. 2022. PMID: 35243298 Free PMC article. Review.
This condition causes joint pain, loss of function, and deterioration of quality of life, mainly due to osteoarthritis (OA) and rheumatoid arthritis (RA). Currently, available treatment options for inflammatory arthritis include anti-inflammatory medications administered v …
This condition causes joint pain, loss of function, and deterioration of quality of life, mainly due to osteoarthritis (OA) and rheum …
Topical Diclofenac Reduces Joint Synovitis in Hand Osteoarthritis: A Pilot Investigation Using Fluorescent Optical Imaging.
Mantantzis K, Franks B, Kachroo P, Boncheva Bettex M. Mantantzis K, et al. J Pain Res. 2024 Jun 26;17:2279-2286. doi: 10.2147/JPR.S463633. eCollection 2024. J Pain Res. 2024. PMID: 38947131 Free PMC article.
PATIENTS AND METHODS: Ten patients with symptomatic and diagnosed HOA used topical diclofenac for 14 days, with FOI, MRI, US, and subjective pain assessed at Baseline and after 7 (Day 8), and 14 (Day 15) days of treatment. ...CONCLUSION: This pilot study evidenced t …
PATIENTS AND METHODS: Ten patients with symptomatic and diagnosed HOA used topical diclofenac for 14 days, with FOI, MRI, US, …
164 results