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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1957 1
1990 3
1991 5
1992 13
1993 27
1994 41
1995 53
1996 90
1997 95
1998 108
1999 124
2000 140
2001 182
2002 171
2003 143
2004 171
2005 160
2006 167
2007 167
2008 149
2009 127
2010 153
2011 144
2012 152
2013 131
2014 149
2015 151
2016 128
2017 128
2018 135
2019 127
2020 118
2021 152
2022 113
2023 10
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3,596 results
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Page 1
Myelopreservation with Trilaciclib in Patients Receiving Topotecan for Small Cell Lung Cancer: Results from a Randomized, Double-Blind, Placebo-Controlled Phase II Study.
Hart LL, Ferrarotto R, Andric ZG, Beck JT, Subramanian J, Radosavljevic DZ, Zaric B, Hanna WT, Aljumaily R, Owonikoko TK, Verhoeven D, Xiao J, Morris SR, Antal JM, Hussein MA. Hart LL, et al. Adv Ther. 2021 Jan;38(1):350-365. doi: 10.1007/s12325-020-01538-0. Epub 2020 Oct 29. Adv Ther. 2021. PMID: 33123968 Free PMC article. Clinical Trial.
METHODS: In this randomized, double-blind, placebo-controlled phase II trial, patients with previously treated extensive-stage small cell lung cancer (ES-SCLC) were randomized to receive intravenous trilaciclib 240 mg/m(2) or placebo before topotecan 1.5 mg/m(2) on days 1- …
METHODS: In this randomized, double-blind, placebo-controlled phase II trial, patients with previously treated extensive-stage small cell lu …
Ocular pharmacology of topotecan and its activity in retinoblastoma.
Schaiquevich P, Carcaboso AM, Buitrago E, Taich P, Opezzo J, Bramuglia G, Chantada GL. Schaiquevich P, et al. Retina. 2014 Sep;34(9):1719-27. doi: 10.1097/IAE.0000000000000253. Retina. 2014. PMID: 25099219 Review.
Topotecan administered intraophthalmic artery shows higher passage to the vitreous compared with periocular administration in a swine model. CONCLUSION: Topotecan alone or in combination is active against retinoblastoma. ...
Topotecan administered intraophthalmic artery shows higher passage to the vitreous compared with periocular administration in a swine
Efficacy of cisplatin combined with topotecan in patients with advanced or recurrent ovarian cancer as second- or higher-line palliative chemotherapy.
Lee MW, Ryu H, Song IC, Yun HJ, Jo DY, Ko YB, Lee HJ. Lee MW, et al. Medicine (Baltimore). 2020 Apr;99(17):e19931. doi: 10.1097/MD.0000000000019931. Medicine (Baltimore). 2020. PMID: 32332673 Free PMC article.
The aim of this study was to evaluate the outcomes of patients with advanced or recurrent ovarian cancer treated with cisplatin combined with topotecan as second- or higher-line palliative chemotherapy.We retrospectively reviewed the medical records of patients with advanc …
The aim of this study was to evaluate the outcomes of patients with advanced or recurrent ovarian cancer treated with cisplatin combined wit …
Topotecan in cervical cancer.
Ackermann S, Beckmann MW, Thiel F, Bogenrieder T. Ackermann S, et al. Int J Gynecol Cancer. 2007 Nov-Dec;17(6):1215-23. doi: 10.1111/j.1525-1438.2007.01003.x. Int J Gynecol Cancer. 2007. PMID: 17997795 Review.
We therefore conducted a systematic review on the studies using topotecan in cervical cancer. Seven phase I-III clinical trials using topotecan, both as a single agent and in combination with cisplatin or paclitaxel, in patients with recurrent or advanced carcinoma …
We therefore conducted a systematic review on the studies using topotecan in cervical cancer. Seven phase I-III clinical trials using …
Weekly topotecan as second- or third-line treatment in patients with recurrent or metastatic cervical cancer.
Coronel J, Cetina L, Candelaria M, González-Fierro A, Arias D, Cantu D, Dueñas-González A. Coronel J, et al. Med Oncol. 2009;26(2):210-4. doi: 10.1007/s12032-008-9108-5. Epub 2008 Oct 28. Med Oncol. 2009. PMID: 19016011 Clinical Trial.
Topotecan is active in advanced or metastatic cervical cancer even in patients who have received prior cisplatin-based chemotherapy, although hematologic toxicity has limited its use. ...The objective of this study was to analyze the results of weekly topotecan as s
Topotecan is active in advanced or metastatic cervical cancer even in patients who have received prior cisplatin-based chemotherapy,
Topotecan in the management of cervical cancer.
Randall-Whitis LM, Monk BJ. Randall-Whitis LM, et al. Expert Opin Pharmacother. 2007 Feb;8(2):227-36. doi: 10.1517/14656566.8.2.227. Expert Opin Pharmacother. 2007. PMID: 17257092 Review.
Topotecan, a semisynthetic camptothecin, exerts its cytotoxic effect through inhibition of DNA topoisomerase I. Single-agent topotecan has demonstrated activity against persistent, metastatic and recurrent cancer of the uterine cervix. ...
Topotecan, a semisynthetic camptothecin, exerts its cytotoxic effect through inhibition of DNA topoisomerase I. Single-agent topot
Combined intravitreal melphalan and topotecan for refractory or recurrent vitreous seeding from retinoblastoma.
Ghassemi F, Shields CL, Ghadimi H, Khodabandeh A, Roohipoor R. Ghassemi F, et al. JAMA Ophthalmol. 2014 Aug;132(8):936-41. doi: 10.1001/jamaophthalmol.2014.414. JAMA Ophthalmol. 2014. PMID: 24789622
OBJECTIVE: To determine the efficacy and complications of combined intravitreal chemotherapy (melphalan hydrochloride and topotecan hydrochloride) for viable vitreous seeding from retinoblastoma. ...CONCLUSIONS AND RELEVANCE: Administration of combined intravitreal melphal …
OBJECTIVE: To determine the efficacy and complications of combined intravitreal chemotherapy (melphalan hydrochloride and topotecan h …
Review role of topotecan in gynaecological cancers: current indications and perspectives.
Lorusso D, Pietragalla A, Mainenti S, Masciullo V, Di Vagno G, Scambia G. Lorusso D, et al. Crit Rev Oncol Hematol. 2010 Jun;74(3):163-74. doi: 10.1016/j.critrevonc.2009.08.001. Epub 2009 Sep 18. Crit Rev Oncol Hematol. 2010. PMID: 19766512 Review.
METHODS: This article reviews the mechanism of action, pharmacokinetics, toxicity and efficacy of topotecan. The paper also reports the principal phases II and III studies of topotecan in advanced or recurrent ovarian and cervical cancer. ...Haematological toxicity …
METHODS: This article reviews the mechanism of action, pharmacokinetics, toxicity and efficacy of topotecan. The paper also reports t …
Topotecan: a review of its efficacy in small cell lung cancer.
Ormrod D, Spencer CM. Ormrod D, et al. Drugs. 1999 Sep;58(3):533-51. doi: 10.2165/00003495-199958030-00020. Drugs. 1999. PMID: 10493279 Review.
The tolerability and compliance advantages of oral topotecan may make this the route of choice in the future. Noncumulative anaemia, neutropenia and thrombocytopenia are the dose-limiting adverse effects associated with topotecan. CAV and topotecan therapy ha …
The tolerability and compliance advantages of oral topotecan may make this the route of choice in the future. Noncumulative anaemia, …
Recent advances with topotecan in the treatment of lung cancer.
O'Brien M, Eckardt J, Ramlau R. O'Brien M, et al. Oncologist. 2007 Oct;12(10):1194-204. doi: 10.1634/theoncologist.12-10-1194. Oncologist. 2007. PMID: 17962613 Free article. Review.
Topotecan is a semisynthetic derivative of camptothecin that specifically targets topoisomerase I. ...Recent studies demonstrate the utility of i.v. topotecan in combination with cisplatin for untreated SCLC. Further, an oral formulation of topotecan is curre
Topotecan is a semisynthetic derivative of camptothecin that specifically targets topoisomerase I. ...Recent studies demonstrate the
3,596 results