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2006 1
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Page 1
The human B12 trafficking protein CblC processes nitrocobalamin.
Mascarenhas R, Li Z, Gherasim C, Ruetz M, Banerjee R. Mascarenhas R, et al. J Biol Chem. 2020 Jul 10;295(28):9630-9640. doi: 10.1074/jbc.RA120.014094. Epub 2020 May 26. J Biol Chem. 2020. PMID: 32457044 Free PMC article.
In humans, cobalamin or vitamin B(12) is delivered to two target enzymes via a complex intracellular trafficking pathway comprising transporters and chaperones. ...In summary, upon exposure to air, NOCbl is rapidly converted to NO(2)Cbl, …
In humans, cobalamin or vitamin B(12) is delivered to two target enzymes via a complex intracellular traffick
Redox-Linked Coordination Chemistry Directs Vitamin B12 Trafficking.
Banerjee R, Gouda H, Pillay S. Banerjee R, et al. Acc Chem Res. 2021 Apr 20;54(8):2003-2013. doi: 10.1021/acs.accounts.1c00083. Epub 2021 Apr 2. Acc Chem Res. 2021. PMID: 33797888 Free PMC article.
While cells are known to house a cadre of chaperones dedicated to metal trafficking pathways that contain metal reactivity and confer targeting specificity, the seemingly supernumerary chaperones in the B(12) pathway had raised obvious questions …
While cells are known to house a cadre of chaperones dedicated to metal trafficking pathways that contain metal reactivity and …
Destabilization of a bovine B₁₂ trafficking chaperone protein by oxidized form of glutathione.
Park J, Jeong J, Kim J. Park J, et al. Biochem Biophys Res Commun. 2012 Apr 13;420(3):547-51. doi: 10.1016/j.bbrc.2012.03.031. Epub 2012 Mar 13. Biochem Biophys Res Commun. 2012. PMID: 22446328
The protein, bCblCpro, is a bovine B(12) trafficking chaperone involved in intracellular B(12) metabolism. bCblCpro is highly thermolabile (T(m)=42C) and the reduced form of glutathione, GSH, has been found to stabilize bCblCpro as a posi …
The protein, bCblCpro, is a bovine B(12) trafficking chaperone involved in intracellular B(12) met …
Decyanation of vitamin B12 by a trafficking chaperone.
Kim J, Gherasim C, Banerjee R. Kim J, et al. Proc Natl Acad Sci U S A. 2008 Sep 23;105(38):14551-4. doi: 10.1073/pnas.0805989105. Epub 2008 Sep 8. Proc Natl Acad Sci U S A. 2008. PMID: 18779575 Free PMC article.
The mystery of how the cyanide group in vitamin B(12) or cyanocobalamin, discovered 60 years ago, is removed, has been solved by the demonstration that the trafficking chaperone, MMACHC, catalyzes a reductive decyanation reaction. ...Defects in …
The mystery of how the cyanide group in vitamin B(12) or cyanocobalamin, discovered 60 years ago, is removed, has been …
Protection of aquo/hydroxocobalamin from reduced glutathione by a B12 trafficking chaperone.
Jeong J, Ha TS, Kim J. Jeong J, et al. BMB Rep. 2011 Mar;44(3):170-5. doi: 10.5483/BMBRep.2011.44.3.170. BMB Rep. 2011. PMID: 21429294 Free article.
We identified a bovine B(12) trafficking chaperone bCblC in Bos taurus that showed 88% amino acid sequence identity with a human homologue. ...Furthermore we found that bCblC eliminates the GSH ligand of GSCbl forming OH(2)/ OHCbl. The results demonstr …
We identified a bovine B(12) trafficking chaperone bCblC in Bos taurus that showed 88% amino acid sequence ident …
An Interprotein Co-S Coordination Complex in the B12-Trafficking Pathway.
Li Z, Mascarenhas R, Twahir UT, Kallon A, Deb A, Yaw M, Penner-Hahn J, Koutmos M, Warncke K, Banerjee R. Li Z, et al. J Am Chem Soc. 2020 Sep 23;142(38):16334-16345. doi: 10.1021/jacs.0c06590. Epub 2020 Sep 14. J Am Chem Soc. 2020. PMID: 32871076 Free PMC article.
The CblC and CblD chaperones are involved in early steps in the cobalamin trafficking pathway. ...Our study provides insights into how cobalamin coordination chemistry could be utilized for cofactor translocation in the trafficking pathway....
The CblC and CblD chaperones are involved in early steps in the cobalamin trafficking pathway. ...Our study provides in …
Processing of glutathionylcobalamin by a bovine B12 trafficking chaperone bCblC involved in intracellular B12 metabolism.
Jeong J, Park J, Park J, Kim J. Jeong J, et al. Biochem Biophys Res Commun. 2014 Jan 3;443(1):173-8. doi: 10.1016/j.bbrc.2013.11.075. Epub 2013 Nov 25. Biochem Biophys Res Commun. 2014. PMID: 24286755
Glutathionylcobalamin (GSCbl) is a biologically relevant vitamin B12 derivative and contains glutathione as the upper axial ligand thought formation of a cobalt-sulfur bond. ...In this study, we discovered that bCblC, a bovine B12 trafficking chaperone, catal …
Glutathionylcobalamin (GSCbl) is a biologically relevant vitamin B12 derivative and contains glutathione as the upper axial ligand th …
C-terminal truncation of a bovine B(12) trafficking chaperone enhances the sensitivity of the glutathione-regulated thermostability.
Jeong J, Park J, Lee DY, Kim J. Jeong J, et al. BMB Rep. 2013 Mar;46(3):169-74. doi: 10.5483/bmbrep.2013.46.3.158. BMB Rep. 2013. PMID: 23527861 Free PMC article.
The human B(12) trafficking chaperone hCblC is well conserved in mammals and non-mammalian eukaryotes. ...
The human B(12) trafficking chaperone hCblC is well conserved in mammals and non-mammalian eukaryotes. ...
Glutathione and vitamin B₁₂ cooperate in stabilization of a B₁₂ trafficking chaperone protein.
Park J, Kim J. Park J, et al. Protein J. 2012 Feb;31(2):158-65. doi: 10.1007/s10930-011-9385-2. Protein J. 2012. PMID: 22207483
The protein bCblC (bCblCpro) is a bovine homolog of a human B12 trafficking chaperone that is responsible for the processing of vitamin B12 and its escorted delivery in intracellular B12 metabolism. ...The results in this study indicate that GSH cooperates wi …
The protein bCblC (bCblCpro) is a bovine homolog of a human B12 trafficking chaperone that is responsible for the processing o …
B12 trafficking in mammals: A for coenzyme escort service.
Banerjee R. Banerjee R. ACS Chem Biol. 2006 Apr 25;1(3):149-59. doi: 10.1021/cb6001174. ACS Chem Biol. 2006. PMID: 17163662 Review.
They are often both rare and reactive rendering the likelihood low that the cell uses a collision-based strategy for their delivery to dependent enzymes. In humans, there are only two known B12 or cobalamin-dependent enzymes: methionine synthase and methylmalonyl-CoA mutas …
They are often both rare and reactive rendering the likelihood low that the cell uses a collision-based strategy for their delivery to depen …
23 results