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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1976 1
1977 1
1978 1
1979 1
1980 1
1982 1
1984 1
1985 1
1986 1
1987 3
1988 1
1989 3
1990 1
1991 3
1992 2
1993 3
1994 3
1995 18
1996 40
1997 50
1998 117
1999 133
2000 190
2001 213
2002 221
2003 249
2004 235
2005 279
2006 288
2007 318
2008 269
2009 284
2010 282
2011 257
2012 248
2013 256
2014 235
2015 231
2016 196
2017 213
2018 177
2019 160
2020 162
2021 160
2022 144
2023 122
2024 128
2025 122
2026 80

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5,548 results

Results by year

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Page 1
Zooming in on Transcription Preinitiation.
Gupta K, Sari-Ak D, Haffke M, Trowitzsch S, Berger I. Gupta K, et al. J Mol Biol. 2016 Jun 19;428(12):2581-2591. doi: 10.1016/j.jmb.2016.04.003. Epub 2016 Apr 8. J Mol Biol. 2016. PMID: 27067110 Free PMC article. Review.
Class II gene transcription commences with the assembly of the Preinitiation Complex (PIC) from a plethora of proteins and protein assemblies in the nucleus, including the General Transcription Factors (GTFs), RNA polymerase II (RNA pol II), co-activators …
Class II gene transcription commences with the assembly of the Preinitiation Complex (PIC) from a plethora of proteins and pro …
Targeting retinoic acid receptor alpha-corepressor interaction activates chaperone-mediated autophagy and protects against retinal degeneration.
Gomez-Sintes R, Xin Q, Jimenez-Loygorri JI, McCabe M, Diaz A, Garner TP, Cotto-Rios XM, Wu Y, Dong S, Reynolds CA, Patel B, de la Villa P, Macian F, Boya P, Gavathiotis E, Cuervo AM. Gomez-Sintes R, et al. Nat Commun. 2022 Jul 21;13(1):4220. doi: 10.1038/s41467-022-31869-1. Nat Commun. 2022. PMID: 35864098 Free PMC article.
Chaperone-mediated autophagy activating molecules stabilize the interaction between retinoic acid receptor alpha - a known endogenous inhibitor of chaperone-mediated autophagy - and its co-repressor, nuclear receptor corepressor 1, resulting in changes …
Chaperone-mediated autophagy activating molecules stabilize the interaction between retinoic acid receptor alpha - a known endogenous …
Class IIa HDAC4 and HDAC7 cooperatively regulate gene transcription in Th17 cell differentiation.
Cheung KL, Zhao L, Sharma R, Ghosh AA, Appiah M, Sun Y, Jaganathan A, Hu Y, LeJeune A, Xu F, Han X, Wang X, Zhang F, Ren C, Walsh MJ, Xiong H, Tsankov A, Zhou MM. Cheung KL, et al. Proc Natl Acad Sci U S A. 2024 Apr 30;121(18):e2312111121. doi: 10.1073/pnas.2312111121. Epub 2024 Apr 24. Proc Natl Acad Sci U S A. 2024. PMID: 38657041 Free PMC article.
Mechanistically, Hdac4 interacts with the transcription factor (TF) JunB, facilitating the transcriptional activation of Th17 signature genes such as Il17a/f. Conversely, Hdac7 collaborates with the TF Aiolos and Smrt/Ncor1-Hdac3 corepressors to repres …
Mechanistically, Hdac4 interacts with the transcription factor (TF) JunB, facilitating the transcriptional activation o …
CtBP1/2 oligomerization promotes G9a-Mediated transcriptional repression.
Zhang B, Jiang J, Sun W, Hu S, Chen P, Li L, Jiang M, Chen J, Zeng J, Cai D, Luo Q, Liu W, Cai Q, Chen S. Zhang B, et al. J Biol Chem. 2026 Feb;302(2):111063. doi: 10.1016/j.jbc.2025.111063. Epub 2025 Dec 17. J Biol Chem. 2026. PMID: 41419197 Free PMC article.
Corepressors CtBP1 and CtBP2 (CtBP1/2) are evolutionarily conserved transcriptional regulators that repress gene expression by recruiting chromatin modifiers, yet the structural basis of this process remains elusive. ...This interaction enhances G9a catalytic act …
Corepressors CtBP1 and CtBP2 (CtBP1/2) are evolutionarily conserved transcriptional regulators that repress gene expression by …
HDAC7 influences ER- transcription via NCoR-HDAC3 dissociation.
Kodikara IKM, Nwanelo VO, Belanger AK, Pflum MKH. Kodikara IKM, et al. Biochim Biophys Acta Proteins Proteom. 2025 Sep 1;1873(5):141083. doi: 10.1016/j.bbapap.2025.141083. Epub 2025 Jun 11. Biochim Biophys Acta Proteins Proteom. 2025. PMID: 40513928 Free PMC article.
However, HDAC7 is a pseudodeacetylase that displays weak enzymatic activity and cannot directly deacetylate histones. Instead, HDAC7 scaffolds histones to active HDAC3 (histone deacetylase 3) via NCoR (nuclear receptor corepressor) to regulate transcriptio …
However, HDAC7 is a pseudodeacetylase that displays weak enzymatic activity and cannot directly deacetylate histones. Instead, HDAC7 …
The Dynamic Regulation of Daxx-Mediated Transcriptional Inhibition by SUMO and PML NBs.
Gao J, Liu T, Yang D, Tuo Q. Gao J, et al. Int J Mol Sci. 2025 Jul 12;26(14):6703. doi: 10.3390/ijms26146703. Int J Mol Sci. 2025. PMID: 40724953 Free PMC article. Review.
SUMOylation plays a crucial role in regulating gene expression by promoting interactions between transcription factors and corepressors. Daxx, a multifunctional scaffold protein, specifically recognizes and binds SUMOylated transcription factors through its S …
SUMOylation plays a crucial role in regulating gene expression by promoting interactions between transcription factors and corepre …
Rpd3/CoRest-mediated activity-dependent transcription regulates the flexibility in memory updating in Drosophila.
Takakura M, Nakagawa R, Ota T, Kimura Y, Ng MY, Alia AG, Okuno H, Hirano Y. Takakura M, et al. Nat Commun. 2021 Jan 27;12(1):628. doi: 10.1038/s41467-021-20898-x. Nat Commun. 2021. PMID: 33504795 Free PMC article.
Here, we explored the gating mechanism for activity-dependent transcription in memory consolidation, which is unexpectedly linked to the later memory updating in Drosophila. Through proteomic analysis, we discovered that the compositional change in the transcript …
Here, we explored the gating mechanism for activity-dependent transcription in memory consolidation, which is unexpectedly lin …
Transcriptional co-repressors and memory storage.
Schoch H, Abel T. Schoch H, et al. Neuropharmacology. 2014 May;80:53-60. doi: 10.1016/j.neuropharm.2014.01.003. Epub 2014 Jan 17. Neuropharmacology. 2014. PMID: 24440532 Free PMC article. Review.
Chromatin modifying enzymes are frequently incorporated into large multi-protein co-activator and co-repressor complexes, where the activity of multiple enzymes is both spatially and temporally coordinated. In this review, we discuss negative regulatio …
Chromatin modifying enzymes are frequently incorporated into large multi-protein co-activator and co-repressor complexe …
Involvement of HDAC2-mediated kcnq2/kcnq3 genes transcription repression activated by EREG/EGFR-ERK-Runx1 signaling in bone cancer pain.
Zhang ZX, Tian Y, Li S, Jing HB, Cai J, Li M, Xing GG. Zhang ZX, et al. Cell Commun Signal. 2024 Aug 27;22(1):416. doi: 10.1186/s12964-024-01797-2. Cell Commun Signal. 2024. PMID: 39192337 Free PMC article.
Also, HDAC2 requires the formation of a corepressor complex with MeCP2 and Sin3A to execute transcriptional regulation of kcnq2/kcnq3 genes. Moreover, EREG is identified as an upstream signal molecule for HDAC2-mediated kcnq2/kcnq3 genes transcription repress …
Also, HDAC2 requires the formation of a corepressor complex with MeCP2 and Sin3A to execute transcriptional regulation of kcnq …
Histone H3.3 phosphorylation amplifies stimulation-induced transcription.
Armache A, Yang S, Martínez de Paz A, Robbins LE, Durmaz C, Cheong JQ, Ravishankar A, Daman AW, Ahimovic DJ, Klevorn T, Yue Y, Arslan T, Lin S, Panchenko T, Hrit J, Wang M, Thudium S, Garcia BA, Korb E, Armache KJ, Rothbart SB, Hake SB, Allis CD, Li H, Josefowicz SZ. Armache A, et al. Nature. 2020 Jul;583(7818):852-857. doi: 10.1038/s41586-020-2533-0. Epub 2020 Jul 22. Nature. 2020. PMID: 32699416 Free PMC article.
This regulation occurs in the context of large genomes condensed by histone proteins into chromatin. The sensing of pathogens by macrophages engages conserved signalling pathways and transcription factors to coordinate the induction of inflammatory genes(1-3). ...Th …
This regulation occurs in the context of large genomes condensed by histone proteins into chromatin. The sensing of pathogens by macr …
5,548 results