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83 results

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A Legionella toxin exhibits tRNA mimicry and glycosyl transferase activity to target the translation machinery and trigger a ribotoxic stress response.
Subramanian A, Wang L, Moss T, Voorhies M, Sangwan S, Stevenson E, Pulido EH, Kwok S, Chalkley RJ, Li KH, Krogan NJ, Swaney DL, Burlingame AL, Floor SN, Sil A, Walter P, Mukherjee S. Subramanian A, et al. Nat Cell Biol. 2023 Nov;25(11):1600-1615. doi: 10.1038/s41556-023-01248-z. Epub 2023 Oct 19. Nat Cell Biol. 2023. PMID: 37857833 Free PMC article.
A widespread strategy employed by pathogens to establish infection is to inhibit host-cell protein synthesis. Legionella pneumophila, an intracellular bacterial pathogen and the causative organism of Legionnaires' disease, secretes a subset of protein …
A widespread strategy employed by pathogens to establish infection is to inhibit host-cell protein synthesis. Legionella …
The Legionella pneumophila Metaeffector Lpg2505 (MesI) Regulates SidI-Mediated Translation Inhibition and Novel Glycosyl Hydrolase Activity.
Joseph AM, Pohl AE, Ball TJ, Abram TG, Johnson DK, Geisbrecht BV, Shames SR. Joseph AM, et al. Infect Immun. 2020 Apr 20;88(5):e00853-19. doi: 10.1128/IAI.00853-19. Print 2020 Apr 20. Infect Immun. 2020. PMID: 32122942 Free PMC article.
SidI is a cytotoxic effector that interacts with the host translation factor eEF1A and potently inhibits eukaryotic protein translation by an unknown mechanism. ...We determined that Lpg2505 binds with nanomolar affinity to SidI and suppresses SidI-med …
SidI is a cytotoxic effector that interacts with the host translation factor eEF1A and potently inhibits eukaryotic protein …
Targeting Eukaryotic mRNA Translation by Legionella pneumophila.
Belyi Y. Belyi Y. Front Mol Biosci. 2020 Apr 29;7:80. doi: 10.3389/fmolb.2020.00080. eCollection 2020. Front Mol Biosci. 2020. PMID: 32411722 Free PMC article. Review.
Once within the cytoplasm, effectors modify a broad range of host activities, including mRNA translation. Translation is inhibited by Legionella through the action of several effector proteins including Lgt1, Lgt2, Lgt3, SidI, LegK4, SidL, and RavX. .. …
Once within the cytoplasm, effectors modify a broad range of host activities, including mRNA translation. Translation is in …
Apolipoprotein E controls Dectin-1-dependent development of monocyte-derived alveolar macrophages upon pulmonary β-glucan-induced inflammatory adaptation.
Theobald H, Bejarano DA, Katzmarski N, Haub J, Schulte-Schrepping J, Yu J, Bassler K, Ament AL, Osei-Sarpong C, Piattini F, Vornholz L, T'Jonck W, Györfi AH, Hayer H, Yu X, Sheoran S, Al Jawazneh A, Chakarov S, Haendler K, Brown GD, Williams DL, Bosurgi L, Distler JHW, Ginhoux F, Ruland J, Beyer MD, Greter M, Bain CC, Vazquez-Armendariz AI, Kopf M, Schultze JL, Schlitzer A. Theobald H, et al. Nat Immunol. 2024 Jun;25(6):994-1006. doi: 10.1038/s41590-024-01830-z. Epub 2024 Apr 26. Nat Immunol. 2024. PMID: 38671323 Free PMC article.
Functional differences were cell intrinsic, and myeloid cell-specific ApoE ablation inhibited Ly6c(+) monocyte to ApoE(+)CD11b(+) AM differentiation dependent on macrophage colony-stimulating factor secretion, promoting ApoE(+)CD11b(+) AM cell death and thus impeding ApoE( …
Functional differences were cell intrinsic, and myeloid cell-specific ApoE ablation inhibited Ly6c(+) monocyte to ApoE(+)CD11b(+) AM …
5' Untranslated mRNA Regions Allow Bypass of Host Cell Translation Inhibition by Legionella pneumophila.
Lipo E, Asrat S, Huo W, Sol A, Fraser CS, Isberg RR. Lipo E, et al. Infect Immun. 2022 Nov 17;90(11):e0017922. doi: 10.1128/iai.00179-22. Epub 2022 Nov 2. Infect Immun. 2022. PMID: 36321832 Free PMC article.
Legionella pneumophila grows within membrane-bound vacuoles in alveolar macrophages during human disease. ...These proteins were predicted to be among the most efficiently translated per unit transcript in the cell based on ribosome profiling data sets. To determine …
Legionella pneumophila grows within membrane-bound vacuoles in alveolar macrophages during human disease. ...These proteins were pred …
Inhibition of host cell translation elongation by Legionella pneumophila blocks the host cell unfolded protein response.
Hempstead AD, Isberg RR. Hempstead AD, et al. Proc Natl Acad Sci U S A. 2015 Dec 8;112(49):E6790-7. doi: 10.1073/pnas.1508716112. Epub 2015 Nov 23. Proc Natl Acad Sci U S A. 2015. PMID: 26598709 Free PMC article.
L. pneumophila TLR ligands induced the splicing of mRNA encoding XBP1s, the main target of IRE1 activity. L. pneumophila was able to inhibit both chemical and bacterial induction of XBP1 splicing via bacterial translocated proteins that interfere with host protein …
L. pneumophila TLR ligands induced the splicing of mRNA encoding XBP1s, the main target of IRE1 activity. L. pneumophila was able to inhi …
KKL-35 Exhibits Potent Antibiotic Activity against Legionella Species Independently of trans-Translation Inhibition.
Brunel R, Descours G, Durieux I, Doublet P, Jarraud S, Charpentier X. Brunel R, et al. Antimicrob Agents Chemother. 2018 Jan 25;62(2):e01459-17. doi: 10.1128/AAC.01459-17. Print 2018 Feb. Antimicrob Agents Chemother. 2018. PMID: 29158279 Free PMC article.
trans-Translation is a ribosome-rescue system that is ubiquitous in bacteria. Small molecules defining a new family of oxadiazole compounds that inhibit trans-translation have been found to have broad-spectrum antibiotic activity. ...Consistent with the essen …
trans-Translation is a ribosome-rescue system that is ubiquitous in bacteria. Small molecules defining a new family of oxadiazole com …
Divergence of Legionella Effectors Reversing Conventional and Unconventional Ubiquitination.
Kitao T, Nagai H, Kubori T. Kitao T, et al. Front Cell Infect Microbiol. 2020 Aug 21;10:448. doi: 10.3389/fcimb.2020.00448. eCollection 2020. Front Cell Infect Microbiol. 2020. PMID: 32974222 Free PMC article. Review.
The intracellular bacterial pathogen Legionella pneumophila employs bacteria-derived effector proteins in a variety of functions to exploit host cellular systems. ...Furthermore, novel mechanisms have been found that adversely affect the function of specific ubiquitin liga …
The intracellular bacterial pathogen Legionella pneumophila employs bacteria-derived effector proteins in a variety of functions to e …
Structural insights into the mechanism and inhibition of transglutaminase-induced ubiquitination by the Legionella effector MavC.
Mu Y, Wang Y, Huang Y, Li D, Han Y, Chang M, Fu J, Xie Y, Ren J, Wang H, Zhang Y, Luo ZQ, Feng Y. Mu Y, et al. Nat Commun. 2020 Apr 14;11(1):1774. doi: 10.1038/s41467-020-15645-7. Nat Commun. 2020. PMID: 32286321 Free PMC article.
Protein ubiquitination is one of the most prevalent post-translational modifications, controlling virtually every process in eukaryotic cells. Recently, the Legionella effector MavC was found to mediate a unique ubiquitination through transglutamination, link …
Protein ubiquitination is one of the most prevalent post-translational modifications, controlling virtually every process in e …
Legionella longbeachae effector protein RavZ inhibits autophagy and regulates phagosome ubiquitination during infection.
Shi Y, Liu H, Ma K, Luo ZQ, Qiu J. Shi Y, et al. PLoS One. 2023 Feb 9;18(2):e0281587. doi: 10.1371/journal.pone.0281587. eCollection 2023. PLoS One. 2023. PMID: 36758031 Free PMC article.
Legionella organisms are ubiquitous environmental bacteria that are responsible for human Legionnaires' disease, a fatal form of severe pneumonia. ...In this study, we characterized the RavZ (RavZLP) ortholog in L. longbeachae (RavZLLO), the second leading cause of Legi …
Legionella organisms are ubiquitous environmental bacteria that are responsible for human Legionnaires' disease, a fatal form of seve …
83 results