Apolipoprotein E controls Dectin-1-dependent development of monocyte-derived alveolar macrophages upon pulmonary β-glucan-induced inflammatory adaptation.
Theobald H, Bejarano DA, Katzmarski N, Haub J, Schulte-Schrepping J, Yu J, Bassler K, Ament AL, Osei-Sarpong C, Piattini F, Vornholz L, T'Jonck W, Györfi AH, Hayer H, Yu X, Sheoran S, Al Jawazneh A, Chakarov S, Haendler K, Brown GD, Williams DL, Bosurgi L, Distler JHW, Ginhoux F, Ruland J, Beyer MD, Greter M, Bain CC, Vazquez-Armendariz AI, Kopf M, Schultze JL, Schlitzer A.
Theobald H, et al.
Nat Immunol. 2024 Jun;25(6):994-1006. doi: 10.1038/s41590-024-01830-z. Epub 2024 Apr 26.
Nat Immunol. 2024.
PMID: 38671323
Free PMC article.
Functional differences were cell intrinsic, and myeloid cell-specific ApoE ablation inhibited Ly6c(+) monocyte to ApoE(+)CD11b(+) AM differentiation dependent on macrophage colony-stimulating factor secretion, promoting ApoE(+)CD11b(+) AM cell death and thus impeding ApoE( …
Functional differences were cell intrinsic, and myeloid cell-specific ApoE ablation inhibited Ly6c(+) monocyte to ApoE(+)CD11b(+) AM …