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1990 1
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1993 1
1994 1
1996 1
1998 3
2001 1
2002 1
2003 1
2005 1
2006 2
2007 2
2008 1
2009 3
2010 3
2011 2
2012 4
2013 2
2014 2
2015 4
2016 3
2017 3
2018 4
2019 11
2020 11
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68 results
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The Legionella pneumophila Metaeffector Lpg2505 (MesI) Regulates SidI-Mediated Translation Inhibition and Novel Glycosyl Hydrolase Activity.
Joseph AM, Pohl AE, Ball TJ, Abram TG, Johnson DK, Geisbrecht BV, Shames SR. Joseph AM, et al. Infect Immun. 2020 Apr 20;88(5):e00853-19. doi: 10.1128/IAI.00853-19. Print 2020 Apr 20. Infect Immun. 2020. PMID: 32122942 Free PMC article.
SidI is a cytotoxic effector that interacts with the host translation factor eEF1A and potently inhibits eukaryotic protein translation by an unknown mechanism. ...We determined that Lpg2505 binds with nanomolar affinity to SidI and suppresses SidI-med …
SidI is a cytotoxic effector that interacts with the host translation factor eEF1A and potently inhibits eukaryotic protein
Targeting Eukaryotic mRNA Translation by Legionella pneumophila.
Belyi Y. Belyi Y. Front Mol Biosci. 2020 Apr 29;7:80. doi: 10.3389/fmolb.2020.00080. eCollection 2020. Front Mol Biosci. 2020. PMID: 32411722 Free PMC article. Review.
Once within the cytoplasm, effectors modify a broad range of host activities, including mRNA translation. Translation is inhibited by Legionella through the action of several effector proteins including Lgt1, Lgt2, Lgt3, SidI, LegK4, SidL, and RavX. .. …
Once within the cytoplasm, effectors modify a broad range of host activities, including mRNA translation. Translation is in
Lefamulin: Review of a Promising Novel Pleuromutilin Antibiotic.
Veve MP, Wagner JL. Veve MP, et al. Pharmacotherapy. 2018 Sep;38(9):935-946. doi: 10.1002/phar.2166. Epub 2018 Aug 20. Pharmacotherapy. 2018. PMID: 30019769 Review.
Although pleuromutilin antibiotics were first developed in the 1950s, lefamulin is the first to be used for systemic treatment of bacterial infections in humans. Lefamulin exhibits a unique mechanism of action through inhibition of protein synthesis by binding to th …
Although pleuromutilin antibiotics were first developed in the 1950s, lefamulin is the first to be used for systemic treatment of bacterial …
Divergence of Legionella Effectors Reversing Conventional and Unconventional Ubiquitination.
Kitao T, Nagai H, Kubori T. Kitao T, et al. Front Cell Infect Microbiol. 2020 Aug 21;10:448. doi: 10.3389/fcimb.2020.00448. eCollection 2020. Front Cell Infect Microbiol. 2020. PMID: 32974222 Free PMC article. Review.
The intracellular bacterial pathogen Legionella pneumophila employs bacteria-derived effector proteins in a variety of functions to exploit host cellular systems. ...Furthermore, novel mechanisms have been found that adversely affect the function of specific ubiquitin liga …
The intracellular bacterial pathogen Legionella pneumophila employs bacteria-derived effector proteins in a variety of functions to e …
KKL-35 Exhibits Potent Antibiotic Activity against Legionella Species Independently of trans-Translation Inhibition.
Brunel R, Descours G, Durieux I, Doublet P, Jarraud S, Charpentier X. Brunel R, et al. Antimicrob Agents Chemother. 2018 Jan 25;62(2):e01459-17. doi: 10.1128/AAC.01459-17. Print 2018 Feb. Antimicrob Agents Chemother. 2018. PMID: 29158279 Free PMC article.
Small molecules defining a new family of oxadiazole compounds that inhibit trans-translation have been found to have broad-spectrum antibiotic activity. ...Consistent with the essential nature of trans-translation in L. pneumophila, KKL-35 inhibited th …
Small molecules defining a new family of oxadiazole compounds that inhibit trans-translation have been found to have broad-spe …
Structural insights into the mechanism and inhibition of transglutaminase-induced ubiquitination by the Legionella effector MavC.
Mu Y, Wang Y, Huang Y, Li D, Han Y, Chang M, Fu J, Xie Y, Ren J, Wang H, Zhang Y, Luo ZQ, Feng Y. Mu Y, et al. Nat Commun. 2020 Apr 14;11(1):1774. doi: 10.1038/s41467-020-15645-7. Nat Commun. 2020. PMID: 32286321 Free PMC article.
Protein ubiquitination is one of the most prevalent post-translational modifications, controlling virtually every process in eukaryotic cells. Recently, the Legionella effector MavC was found to mediate a unique ubiquitination through transglutamination, link
Protein ubiquitination is one of the most prevalent post-translational modifications, controlling virtually every process in e
Inhibition of host cell translation elongation by Legionella pneumophila blocks the host cell unfolded protein response.
Hempstead AD, Isberg RR. Hempstead AD, et al. Proc Natl Acad Sci U S A. 2015 Dec 8;112(49):E6790-7. doi: 10.1073/pnas.1508716112. Epub 2015 Nov 23. Proc Natl Acad Sci U S A. 2015. PMID: 26598709 Free PMC article.
L. pneumophila TLR ligands induced the splicing of mRNA encoding XBP1s, the main target of IRE1 activity. L. pneumophila was able to inhibit both chemical and bacterial induction of XBP1 splicing via bacterial translocated proteins that interfere with host protein
L. pneumophila TLR ligands induced the splicing of mRNA encoding XBP1s, the main target of IRE1 activity. L. pneumophila was able to inhi
Trans-translation is essential in the human pathogen Legionella pneumophila.
Brunel R, Charpentier X. Brunel R, et al. Sci Rep. 2016 Nov 28;6:37935. doi: 10.1038/srep37935. Sci Rep. 2016. PMID: 27892503 Free PMC article.
Trans-translation is a ubiquitous bacterial mechanism for ribosome rescue in the event of translation stalling. ...We describe here that trans-translation is essential in the human pathogen Legionella pneumophila, the etiologic agent of Legionnaire' …
Trans-translation is a ubiquitous bacterial mechanism for ribosome rescue in the event of translation stalling. ...We describe …
Purification and Analysis of Effector Glucosyltransferase Lgt1 from Legionella pneumophila.
Levanova N, Tabakova I, Jank T, Belyi Y. Levanova N, et al. Methods Mol Biol. 2019;1921:277-287. doi: 10.1007/978-1-4939-9048-1_18. Methods Mol Biol. 2019. PMID: 30694499
Legionella pneumophila is a facultative intracellular pathogen responsible for legionellosis, a severe lung disease in humans. ...This effector modifies serine-53 in eukaryotic elongation factor 1A (eEF1A) by mono-O-glucosylation. Modification of eEF1A results in inhibi
Legionella pneumophila is a facultative intracellular pathogen responsible for legionellosis, a severe lung disease in humans. ...Thi
Legionella pneumophila translocated translation inhibitors are required for bacterial-induced host cell cycle arrest.
Sol A, Lipo E, de Jesús-Díaz DA, Murphy C, Devereux M, Isberg RR. Sol A, et al. Proc Natl Acad Sci U S A. 2019 Feb 19;116(8):3221-3228. doi: 10.1073/pnas.1820093116. Epub 2019 Feb 4. Proc Natl Acad Sci U S A. 2019. PMID: 30718423 Free PMC article.
Previously, we demonstrated that the G(1) and G(2)/M phases of the host cell cycle are permissive for Legionella pneumophila replication, whereas S phase provides a toxic environment for bacterial replication. ...Cell cycle arrest upon Legionella contact is d …
Previously, we demonstrated that the G(1) and G(2)/M phases of the host cell cycle are permissive for Legionella pneumophila replicat …
68 results