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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1965 1
1966 2
1967 9
1968 10
1969 9
1970 10
1971 101
1972 155
1973 154
1974 171
1975 120
1976 157
1977 119
1978 107
1979 122
1980 107
1981 114
1982 103
1983 100
1984 116
1985 94
1986 107
1987 115
1988 126
1989 139
1990 149
1991 165
1992 161
1993 185
1994 261
1995 278
1996 250
1997 269
1998 327
1999 268
2000 275
2001 330
2002 357
2003 345
2004 383
2005 360
2006 438
2007 483
2008 481
2009 486
2010 526
2011 591
2012 624
2013 637
2014 771
2015 714
2016 713
2017 690
2018 668
2019 734
2020 766
2021 840
2022 696
2023 742
2024 709
2025 829
2026 570

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18,968 results

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Page 1
Protein Elongation, Co-translational Folding and Targeting.
Rodnina MV, Wintermeyer W. Rodnina MV, et al. J Mol Biol. 2016 May 22;428(10 Pt B):2165-85. doi: 10.1016/j.jmb.2016.03.022. Epub 2016 Mar 30. J Mol Biol. 2016. PMID: 27038507 Review.
The elongation phase of protein synthesis defines the overall speed and fidelity of protein synthesis and affects protein folding and targeting. ...In this review, we summarize recent findings on mechanisms of translation elongation in ba …
The elongation phase of protein synthesis defines the overall speed and fidelity of protein synthesis and affects pr …
Converting GTP hydrolysis into motion: versatile translational elongation factor G.
Rodnina MV, Peske F, Peng BZ, Belardinelli R, Wintermeyer W. Rodnina MV, et al. Biol Chem. 2019 Dec 18;401(1):131-142. doi: 10.1515/hsz-2019-0313. Biol Chem. 2019. PMID: 31600135 Free article. Review.
Elongation factor G (EF-G) is a translational GTPase that acts at several stages of protein synthesis. Its canonical function is to catalyze tRNA movement during translation elongation, but it also acts at the last step of translation to …
Elongation factor G (EF-G) is a translational GTPase that acts at several stages of protein synthesis. Its canonical fu …
Genome-wide analysis in vivo of translation with nucleotide resolution using ribosome profiling.
Ingolia NT, Ghaemmaghami S, Newman JR, Weissman JS. Ingolia NT, et al. Science. 2009 Apr 10;324(5924):218-23. doi: 10.1126/science.1168978. Epub 2009 Feb 12. Science. 2009. PMID: 19213877 Free PMC article.
Techniques for systematically monitoring protein translation have lagged far behind methods for measuring messenger RNA (mRNA) levels. ...These studies defined the protein sequences being translated and found extensive translational control in b …
Techniques for systematically monitoring protein translation have lagged far behind methods for measuring messenger RNA (mRNA) …
Codon optimality-mediated mRNA degradation: Linking translational elongation to mRNA stability.
Bae H, Coller J. Bae H, et al. Mol Cell. 2022 Apr 21;82(8):1467-1476. doi: 10.1016/j.molcel.2022.03.032. Mol Cell. 2022. PMID: 35452615 Free PMC article. Review.
Messenger RNA (mRNA) translation by the ribosome represents the final step of a complicated molecular dance from DNA to protein. ...Together, these data imply that the coding region of an mRNA not only encodes for protein content but also impacts protein …
Messenger RNA (mRNA) translation by the ribosome represents the final step of a complicated molecular dance from DNA to protein …
Ribosome structure and the mechanism of translation.
Ramakrishnan V. Ramakrishnan V. Cell. 2002 Feb 22;108(4):557-72. doi: 10.1016/s0092-8674(02)00619-0. Cell. 2002. PMID: 11909526 Free article. Review.
The publication of crystal structures of the 50S and 30S ribosomal subunits and the intact 70S ribosome is revolutionizing our understanding of protein synthesis. This review is an attempt to correlate the structures with biochemical and genetic data to identify the gaps a …
The publication of crystal structures of the 50S and 30S ribosomal subunits and the intact 70S ribosome is revolutionizing our understanding …
Translational regulation by modifications of the elongation factor Tu.
Kraal B, Lippmann C, Kleanthous C. Kraal B, et al. Folia Microbiol (Praha). 1999;44(2):131-41. doi: 10.1007/BF02816232. Folia Microbiol (Praha). 1999. PMID: 10588048 Review.
Methylation was found to attenuate GTP hydrolysis and may thus enhance translational accuracy. In vivo 5-10% of EF-Tu is phosphorylated at Thr382 by a ribosome-associated kinase. ...Although the Lit cleavage-mechanism may eventually lead to programmed cell death, the very …
Methylation was found to attenuate GTP hydrolysis and may thus enhance translational accuracy. In vivo 5-10% of EF-Tu is phosphorylat …
Dynamics of Translation of Single mRNA Molecules In Vivo.
Yan X, Hoek TA, Vale RD, Tanenbaum ME. Yan X, et al. Cell. 2016 May 5;165(4):976-89. doi: 10.1016/j.cell.2016.04.034. Cell. 2016. PMID: 27153498 Free PMC article.
Regulation of mRNA translation, the process by which ribosomes decode mRNAs into polypeptides, is used to tune cellular protein levels. ...This approach reveals a surprising heterogeneity in the translation of individual mRNAs within the same cell, including …
Regulation of mRNA translation, the process by which ribosomes decode mRNAs into polypeptides, is used to tune cellular protein …
Single-Molecule Imaging Reveals Translation of mRNAs Localized to Stress Granules.
Mateju D, Eichenberger B, Voigt F, Eglinger J, Roth G, Chao JA. Mateju D, et al. Cell. 2020 Dec 23;183(7):1801-1812.e13. doi: 10.1016/j.cell.2020.11.010. Epub 2020 Dec 11. Cell. 2020. PMID: 33308477 Free article.
Our data indicate that SG-associated translation is not rare, and the entire translation cycle (initiation, elongation, and termination) can occur on SG-localized transcripts. Furthermore, translating mRNAs can be observed transitioning between the cyt …
Our data indicate that SG-associated translation is not rare, and the entire translation cycle (initiation, elongation, …
Elongation factor 2 in cancer: a promising therapeutic target in protein translation.
Jia X, Huang C, Liu F, Dong Z, Liu K. Jia X, et al. Cell Mol Biol Lett. 2024 Dec 20;29(1):156. doi: 10.1186/s11658-024-00674-7. Cell Mol Biol Lett. 2024. PMID: 39707196 Free PMC article. Review.
Aberrant elongation of proteins can lead to the activation of oncogenic signaling pathways, resulting in the dysregulation of oncogenic signaling pathways. Eukaryotic elongation factor 2 (eEF2) is an essential regulator of protein synthesis that precisely …
Aberrant elongation of proteins can lead to the activation of oncogenic signaling pathways, resulting in the dysregulation of oncogen …
RNF14-dependent atypical ubiquitylation promotes translation-coupled resolution of RNA-protein crosslinks.
Zhao S, Cordes J, Caban KM, Götz MJ, Mackens-Kiani T, Veltri AJ, Sinha NK, Weickert P, Kaya S, Hewitt G, Nedialkova DD, Fröhlich T, Beckmann R, Buskirk AR, Green R, Stingele J. Zhao S, et al. Mol Cell. 2023 Dec 7;83(23):4290-4303.e9. doi: 10.1016/j.molcel.2023.10.012. Epub 2023 Nov 10. Mol Cell. 2023. PMID: 37951216 Free PMC article.
Moreover, we discovered a translation-coupled quality control mechanism that resolves covalent RNA-protein crosslinks. ...Ubiquitylation requires the E3 ligase RNF14 and leads to proteasomal degradation of the protein adduct. Our findings identify RNA lesion- …
Moreover, we discovered a translation-coupled quality control mechanism that resolves covalent RNA-protein crosslinks. ...Ubiq …
18,968 results
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