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104,471 results

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Page 1
Did you mean cotranslational protein modification (104,537 results)?
Uncovering post-translational modification-associated protein-protein interactions.
Wang S, Osgood AO, Chatterjee A. Wang S, et al. Curr Opin Struct Biol. 2022 Jun;74:102352. doi: 10.1016/j.sbi.2022.102352. Epub 2022 Mar 22. Curr Opin Struct Biol. 2022. PMID: 35334254 Free PMC article. Review.
In living systems, the chemical space and functional repertoire of proteins are dramatically expanded through the post-translational modification (PTM) of various amino acid residues. These modifications frequently trigger unique protein-protein intera …
In living systems, the chemical space and functional repertoire of proteins are dramatically expanded through the post-translational …
Avenues for post-translational protein modification prevention and therapy.
Tang M, Kalim S. Tang M, et al. Mol Aspects Med. 2022 Aug;86:101083. doi: 10.1016/j.mam.2022.101083. Epub 2022 Feb 25. Mol Aspects Med. 2022. PMID: 35227517 Free PMC article. Review.
Non-enzymatic post-translational modifications (nPTMs) of proteins have emerged as novel risk factors for the genesis and progression of various diseases. ...Using two prime examples-protein carbamylation and AGEs-we discuss the varied preventative and therapeutic o …
Non-enzymatic post-translational modifications (nPTMs) of proteins have emerged as novel risk factors for the genesis and progression …
Post-translational modification enzymes as key regulators of ciliary protein trafficking.
Chaya T, Furukawa T. Chaya T, et al. J Biochem. 2021 Sep 7;169(6):633-642. doi: 10.1093/jb/mvab024. J Biochem. 2021. PMID: 33681987 Free PMC article. Review.
The assembly, disassembly, maintenance and function of cilia rely on protein transport systems including intraflagellar transport (IFT) and lipidated protein intraflagellar targeting (LIFT). ...Recently, it has become clear that several post-translational …
The assembly, disassembly, maintenance and function of cilia rely on protein transport systems including intraflagellar transport (IF …
Post-translational modification and protein sorting to small extracellular vesicles including exosomes by ubiquitin and UBLs.
Ageta H, Tsuchida K. Ageta H, et al. Cell Mol Life Sci. 2019 Dec;76(24):4829-4848. doi: 10.1007/s00018-019-03246-7. Epub 2019 Jul 30. Cell Mol Life Sci. 2019. PMID: 31363817 Free PMC article. Review.
Recent studies have revealed that ubiquitin and UBLs also regulate MVBs and protein sorting to sEVs. Ubiquitin-like 3 (UBL3)/membrane-anchored Ub-fold protein (MUB) acts as a post-translational modification (PTM) factor to regulate efficient protein …
Recent studies have revealed that ubiquitin and UBLs also regulate MVBs and protein sorting to sEVs. Ubiquitin-like 3 (UBL3)/membrane …
Post-translational toxin modification by lactate controls Staphylococcus aureus virulence.
Wang Y, Liu Y, Xiang G, Jian Y, Yang Z, Chen T, Ma X, Zhao N, Dai Y, Lv Y, Wang H, He L, Shi B, Liu Q, Liu Y, Otto M, Li M. Wang Y, et al. Nat Commun. 2024 Nov 13;15(1):9835. doi: 10.1038/s41467-024-53979-8. Nat Commun. 2024. PMID: 39537625 Free PMC article.
Diverse post-translational modifications have been shown to play important roles in regulating protein function in eukaryotes. ...Here, we demonstrate post-translational protein modification by covalent addition of lactate to lysine residues (la …
Diverse post-translational modifications have been shown to play important roles in regulating protein function in eukaryotes. …
Applications of Genetic Code Expansion in Studying Protein Post-translational Modification.
Chen J, Tsai YH. Chen J, et al. J Mol Biol. 2022 Apr 30;434(8):167424. doi: 10.1016/j.jmb.2021.167424. Epub 2021 Dec 28. J Mol Biol. 2022. PMID: 34971673 Review.
Here we focus on the application of genetic code expansion to study site-specific protein post-translational modification in vitro and in vivo. After a brief introduction, we discuss possibilities of incorporating non-canonical amino acids containing post- …
Here we focus on the application of genetic code expansion to study site-specific protein post-translational modification …
Post-translational protein modification as the substrate for long-lasting memory.
Routtenberg A, Rekart JL. Routtenberg A, et al. Trends Neurosci. 2005 Jan;28(1):12-9. doi: 10.1016/j.tins.2004.11.006. Trends Neurosci. 2005. PMID: 15626492 Review.
However, there are enough instances of memory storage in the virtual absence of protein synthesis to prompt consideration of alternative models. A comprehensive review of the protein synthesis literature leads us to conclude that the translational mechanism i …
However, there are enough instances of memory storage in the virtual absence of protein synthesis to prompt consideration of alternat …
OXCT1 functions as a succinyltransferase, contributing to hepatocellular carcinoma via succinylating LACTB.
Ma W, Sun Y, Yan R, Zhang P, Shen S, Lu H, Zhou Z, Jiang Z, Ye L, Mao Q, Xiong N, Jia W, Sun L, Gao P, Zhang H. Ma W, et al. Mol Cell. 2024 Feb 1;84(3):538-551.e7. doi: 10.1016/j.molcel.2023.11.042. Epub 2024 Jan 3. Mol Cell. 2024. PMID: 38176415 Free article.
Metabolic reprogramming is an important feature of cancers that has been closely linked to post-translational protein modification (PTM). Lysine succinylation is a recently identified PTM involved in regulating protein functions, whereas its regulatory …
Metabolic reprogramming is an important feature of cancers that has been closely linked to post-translational protein modif …
Forkhead Box Protein O1: Functional Diversity and Post-Translational Modification, a New Therapeutic Target?
Zhang X, Jiang L, Liu H. Zhang X, et al. Drug Des Devel Ther. 2021 May 3;15:1851-1860. doi: 10.2147/DDDT.S305016. eCollection 2021. Drug Des Devel Ther. 2021. PMID: 33976536 Free PMC article. Review.
FoXO1 activity is regulated in response to different physiological or pathogenic conditions by changes in protein expression and post-translational modifications. Various modifications cooperate to regulate FoXO1 activity and FoXO1 target gene transcription. In this …
FoXO1 activity is regulated in response to different physiological or pathogenic conditions by changes in protein expression and post …
Ubiquitin-A structural perspective.
Agrata R, Komander D. Agrata R, et al. Mol Cell. 2025 Jan 16;85(2):323-346. doi: 10.1016/j.molcel.2024.12.015. Epub 2025 Jan 16. Mol Cell. 2025. PMID: 39824171 Free article. Review.
The modification of proteins and other biomolecules with the small protein ubiquitin has enthralled scientists from many disciplines for decades, creating a broad research field. ...We close with a discussion of the latest frontiers in ubiquitin research, namely the …
The modification of proteins and other biomolecules with the small protein ubiquitin has enthralled scientists from many disci …
104,471 results
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