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Year Number of Results
1958 1
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1964 2
1965 2
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1967 9
1968 2
1969 4
1970 12
1971 12
1972 8
1973 9
1974 9
1975 21
1976 28
1977 40
1978 39
1979 40
1980 66
1981 80
1982 77
1983 81
1984 108
1985 124
1986 127
1987 124
1988 128
1989 138
1990 195
1991 221
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1995 365
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1997 441
1998 456
1999 556
2000 566
2001 631
2002 574
2003 621
2004 699
2005 613
2006 702
2007 708
2008 742
2009 696
2010 736
2011 760
2012 768
2013 783
2014 805
2015 778
2016 776
2017 746
2018 729
2019 758
2020 776
2021 821
2022 692
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22,013 results

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Page 1
Squeeze pumping of lipids and insecticides by ABCH transporter.
Chen J, Duan Y, Zhou Y, Yang Q. Chen J, et al. Cell. 2025 Feb 20;188(4):944-957.e19. doi: 10.1016/j.cell.2024.11.033. Epub 2024 Dec 24. Cell. 2025. PMID: 39721587 Free article.
We revealed a narrow, long, and arched substrate-binding tunnel in the transmembrane domains of the transporter dimer with two arginine-gated cytoplasmic entries for the binding and transport of lipids or insecticides. A pair of glutamines above the tunnel ac …
We revealed a narrow, long, and arched substrate-binding tunnel in the transmembrane domains of the transporter dimer with two …
Membrane-Active Molecular Machines.
Shen J, Ren C, Zeng H. Shen J, et al. Acc Chem Res. 2022 Apr 19;55(8):1148-1159. doi: 10.1021/acs.accounts.1c00804. Epub 2022 Mar 29. Acc Chem Res. 2022. PMID: 35345880
Both biological and artificial membrane transporters mediate passive transmembrane ion flux predominantly via either channel or carrier mechanisms, tightly regulating the transport of materials entering and exiting the cell. ...Applying the same …
Both biological and artificial membrane transporters mediate passive transmembrane ion flux predominantly via ei …
Transporter-mediated Natural Product-Drug Interactions.
Bi Y, Wang X, Ding H, He F, Han L, Zhang Y. Bi Y, et al. Planta Med. 2023 Feb;89(2):119-133. doi: 10.1055/a-1803-1744. Epub 2022 Mar 18. Planta Med. 2023. PMID: 35304735 Review.
The increasing use of natural products in clinical practice has raised great concerns about the potential natural product-drug interactions (NDIs). Drug transporters mediate the transmembrane passage of a broad range of drugs, and thus are important determinants for …
The increasing use of natural products in clinical practice has raised great concerns about the potential natural product-drug interactions …
Structural Elements in the Transmembrane and Cytoplasmic Domains of the Metal Transporter SLC30A10 Are Required for Its Manganese Efflux Activity.
Zogzas CE, Aschner M, Mukhopadhyay S. Zogzas CE, et al. J Biol Chem. 2016 Jul 29;291(31):15940-57. doi: 10.1074/jbc.M116.726935. Epub 2016 Jun 15. J Biol Chem. 2016. PMID: 27307044 Free PMC article.
We previously demonstrated that SLC30A10 is a cell surface-localized manganese efflux transporter, and parkinsonism-causing mutations block its trafficking and efflux activity. ...However, the C-terminal domain failed to transfer manganese transport capabilit …
We previously demonstrated that SLC30A10 is a cell surface-localized manganese efflux transporter, and parkinsonism-causing mutations …
The transmembrane alpha-helix of LptC participates in LPS extraction by the LptB(2) FGC transporter.
Wilson A, Ruiz N. Wilson A, et al. Mol Microbiol. 2022 Jul;118(1-2):61-76. doi: 10.1111/mmi.14952. Epub 2022 Jun 27. Mol Microbiol. 2022. PMID: 35678757 Free PMC article.
The periplasmic domain of LptC is part of the transporter's bridge while its transmembrane alpha-helix intercalates into the LPS-binding cavity of the core LptB(2) FG transporter. LptC's transmembrane helix affects the in vitro ATPase activit …
The periplasmic domain of LptC is part of the transporter's bridge while its transmembrane alpha-helix intercalates int …
[Glucose transporter].
Oka Y. Oka Y. Nihon Rinsho. 1996 Mar;54(3):632-7. Nihon Rinsho. 1996. PMID: 8904216 Review. Japanese.
All mammalian cells contain trans-membrane transport systems for the stereo specific uptake of glucose. These systems are divided into two groups, a facilitated diffusion system driven by the concentration differences across the membrane and an energy-depende …
All mammalian cells contain trans-membrane transport systems for the stereo specific uptake of glucose. These systems are divi …
Structural insights into the mechanisms of urea permeation and distinct inhibition modes of urea transporters.
Huang SM, Huang ZZ, Liu L, Xiong MY, Zhang C, Cai BY, Wang MW, Cai K, Jia YL, Wang JL, Zhang MH, Xie YH, Li M, Zhang H, Weng CH, Wen X, Li Z, Sun Y, Yi F, Yang Z, Xiao P, Yang F, Yu X, Tie L, Yang BX, Sun JP. Huang SM, et al. Nat Commun. 2024 Nov 26;15(1):10226. doi: 10.1038/s41467-024-54305-y. Nat Commun. 2024. PMID: 39587082 Free PMC article.
Urea's transmembrane transport through urea transporters (UT) is a fundamental physiological behavior for life activities. Here, we present 11 cryo-EM structures of four UT members in resting states, urea transport states, or inactive states bou …
Urea's transmembrane transport through urea transporters (UT) is a fundamental physiological behavior for life activ …
ERMA (TMEM94) is a P-type ATPase transporter for Mg(2+) uptake in the endoplasmic reticulum.
Vishnu N, Venkatesan M, Madaris TR, Venkateswaran MK, Stanley K, Ramachandran K, Chidambaram A, Madesh AK, Yang W, Nair J, Narkunan M, Muthukumar T, Karanam V, Joseph LC, Le A, Osidele A, Aslam MI, Morrow JP, Malicdan MC, Stathopulos PB, Madesh M. Vishnu N, et al. Mol Cell. 2024 Apr 4;84(7):1321-1337.e11. doi: 10.1016/j.molcel.2024.02.033. Epub 2024 Mar 20. Mol Cell. 2024. PMID: 38513662 Free PMC article.
Intracellular Mg(2+) ((i)Mg(2+)) is bound with phosphometabolites, nucleic acids, and proteins in eukaryotes. Little is known about the intracellular compartmentalization and molecular details of Mg(2+) transport into/from cellular organelles such as the endoplasmic …
Intracellular Mg(2+) ((i)Mg(2+)) is bound with phosphometabolites, nucleic acids, and proteins in eukaryotes. Little is known about t …
A Novel Bacterial Nitrate Transporter Composed of Small Transmembrane Proteins.
Maeda SI, Aoba R, Nishino Y, Omata T. Maeda SI, et al. Plant Cell Physiol. 2019 Oct 1;60(10):2180-2192. doi: 10.1093/pcp/pcz112. Plant Cell Physiol. 2019. PMID: 31198965 Free article.
A putative silent gene of the freshwater cyanobacterium Synechococcus elongatus strain PCC 7942, encoding a small protein with two transmembrane helices, was named nrtS, since its overexpression from an inducible promoter conferred nitrate uptake activity on the nit …
A putative silent gene of the freshwater cyanobacterium Synechococcus elongatus strain PCC 7942, encoding a small protein with two transm …
Identification of Human TRIAC Transmembrane Transporters.
Becker PC, Güth-Steffens M, Lazarow K, Sonntag N, Braun D, Masfaka I, Renko K, Schomburg L, Köhrle J, von Kries JP, Schweizer U, Krause G, Protze J. Becker PC, et al. Thyroid. 2024 Jul;34(7):920-930. doi: 10.1089/thy.2023.0592. Epub 2024 Jul 1. Thyroid. 2024. PMID: 38801167
MDCK1 cells were stably transfected with cDNA encoding C-terminally myc-tagged versions of the identified TRIAC-preferring transporters. Several individual clones were selected after immunocytochemical characterization for biochemical characterization of their (125)I-TRIAC …
MDCK1 cells were stably transfected with cDNA encoding C-terminally myc-tagged versions of the identified TRIAC-preferring transporters …
22,013 results
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