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A trans-synaptic nanocolumn aligns neurotransmitter release to receptors.
Tang AH, Chen H, Li TP, Metzbower SR, MacGillavry HD, Blanpied TA. Tang AH, et al. Nature. 2016 Aug 11;536(7615):210-4. doi: 10.1038/nature19058. Epub 2016 Jul 27. Nature. 2016. PMID: 27462810 Free PMC article.
Through development of a new method to map vesicle fusion positions within single synapses in cultured rat hippocampal neurons, we find that action-potential-evoked fusion is guided by this protein gradient and occurs preferentially in confined areas with higher local density of …
Through development of a new method to map vesicle fusion positions within single synapses in cultured rat hippocampal neurons, we find that …
LGI1-ADAM22-MAGUK configures transsynaptic nanoalignment for synaptic transmission and epilepsy prevention.
Fukata Y, Chen X, Chiken S, Hirano Y, Yamagata A, Inahashi H, Sanbo M, Sano H, Goto T, Hirabayashi M, Kornau HC, Prüss H, Nambu A, Fukai S, Nicoll RA, Fukata M. Fukata Y, et al. Proc Natl Acad Sci U S A. 2021 Jan 19;118(3):e2022580118. doi: 10.1073/pnas.2022580118. Proc Natl Acad Sci U S A. 2021. PMID: 33397806 Free PMC article.
Physiological functioning and homeostasis of the brain rely on finely tuned synaptic transmission, which involves nanoscale alignment between presynaptic neurotransmitter-release machinery and postsynaptic receptors. However, the molecular identity and …
Physiological functioning and homeostasis of the brain rely on finely tuned synaptic transmission, which involves nanoscale alignment