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Page 1
[Trapidil after one year].
Agus GB. Agus GB. Minerva Cardioangiol. 1993 May;41(5):159-66. Minerva Cardioangiol. 1993. PMID: 8373465 Review. Italian.
In conclusion, in some experimental models Trapidil seems to be able to improve the hemoreologic properties of the blood. Some different clinical studies have demonstrated the therapeutic effectiveness of Trapidil. ...In particular the polycentric study of Bonavita …
In conclusion, in some experimental models Trapidil seems to be able to improve the hemoreologic properties of the blood. Some differ …
Trapidil attenuates diabetic cardiomyopathy via GPX3/Nrf2-mediated inhibition of myocardial pyroptosis.
Wang Z, Sun Y, Wang J, Xu Q, Wang L, Zhang Q, Song J, Wang Y, Qi Z. Wang Z, et al. Front Pharmacol. 2025 Jun 3;16:1566622. doi: 10.3389/fphar.2025.1566622. eCollection 2025. Front Pharmacol. 2025. PMID: 40529489 Free PMC article.
METHODS: The investigation explored the ameliorative effects and uncovered underlying mechanisms of trapidil (TRA), a drug commonly employed in the management of coronary heart disease, on DCM by inhibiting myocardial pyroptosis. ...
METHODS: The investigation explored the ameliorative effects and uncovered underlying mechanisms of trapidil (TRA), a drug commonly e …
Trapidil induces osteogenesis by upregulating the signaling of bone morphogenetic proteins.
Kim B, Lee JH, Jin WJ, Kim HH, Ha H, Lee ZH. Kim B, et al. Cell Signal. 2018 Sep;49:68-78. doi: 10.1016/j.cellsig.2018.06.001. Epub 2018 Jun 5. Cell Signal. 2018. PMID: 29879471
In addition, primary mouse calvarial osteoblast precursors were cultured in osteogenic differentiation medium with trapidil to study the mechanisms. Trapidil greatly promoted bone regeneration in a rat calvarial defect model and osteogenic differentiation of calvari …
In addition, primary mouse calvarial osteoblast precursors were cultured in osteogenic differentiation medium with trapidil to study …
Intrepide; Trapidil eluting stent.
Khan M, Mhulláin FN, Nolan M. Khan M, et al. EuroIntervention. 2008 Nov;4(3):405-11. EuroIntervention. 2008. PMID: 19110816 Review. No abstract available.
Trapidil determines the fate of RHF rats through inhibition of ER stress.
Wang Y, Wang Y, Wei C, Wan Q, Fan Z, Xuan L, Geng W, Shao L, Long J, Gu J, Zhao M. Wang Y, et al. Arch Pharm Res. 2020 Apr;43(4):409-420. doi: 10.1007/s12272-020-01222-5. Epub 2020 Mar 14. Arch Pharm Res. 2020. PMID: 32172437
However, it is difficult to treat. It has been reported that trapidil (Tra) can improve the redox balance and cardiac conditions. In this study, we investigated the effect of Tra on RHF induced by monocrotaline (MCT) in rats. ...
However, it is difficult to treat. It has been reported that trapidil (Tra) can improve the redox balance and cardiac conditions. In …
Trapidil inhibits human mesangial cell proliferation: effect on PDGF beta-receptor binding and expression.
Gesualdo L, Di Paolo S, Ranieri E, Schena FP. Gesualdo L, et al. Kidney Int. 1994 Oct;46(4):1002-9. doi: 10.1038/ki.1994.360. Kidney Int. 1994. PMID: 7861694 Free article.
The present study was aimed at evaluating the effect of Trapidil on human MC in vitro. The addition of 100 to 400 micrograms/ml Trapidil significantly reduced cell proliferation induced by different growth factors (FCS, PDGF-BB, bFGF, EGF), the highest inhibitory ef …
The present study was aimed at evaluating the effect of Trapidil on human MC in vitro. The addition of 100 to 400 micrograms/ml Tr …
Trapidil protects ischemic hearts from reperfusion injury by stimulating PKAII activity.
Sichelschmidt OJ, Hahnefeld C, Hohlfeld T, Herberg FW, Schrör K. Sichelschmidt OJ, et al. Cardiovasc Res. 2003 Jun 1;58(3):602-10. doi: 10.1016/s0008-6363(03)00261-x. Cardiovasc Res. 2003. PMID: 12798433 Free article.
OBJECTIVE: The cardioprotective effects of trapidil on ischemic reperfused (I/R) rabbit hearts were studied. Recently, we had shown that trapidil might activate protein kinase A (PKA). ...This action might be involved in the cardioprotective effects of trapidil …
OBJECTIVE: The cardioprotective effects of trapidil on ischemic reperfused (I/R) rabbit hearts were studied. Recently, we had shown t …
Trapidil, a platelet-derived growth factor antagonist, inhibits osteoclastogenesis by down-regulating NFATc1 and suppresses bone loss in mice.
Kim SD, Kim HN, Lee JH, Jin WJ, Hwang SJ, Kim HH, Ha H, Lee ZH. Kim SD, et al. Biochem Pharmacol. 2013 Sep 15;86(6):782-90. doi: 10.1016/j.bcp.2013.07.015. Epub 2013 Aug 6. Biochem Pharmacol. 2013. PMID: 23928189
In this study, we investigated the effects of trapidil on osteoclastogenesis and elucidated the possible mechanism of action of trapidil. ...Ectopic expression of a constitutively active form of NFATc1 reversed the anti-osteoclastogenic effect of trapidil, in …
In this study, we investigated the effects of trapidil on osteoclastogenesis and elucidated the possible mechanism of action of tr …
Trapidil improves hemodynamic, echocardiographic and redox state parameters of right ventricle in monocrotaline-induced pulmonary arterial hypertension model.
Türck P, Lacerda DS, Carraro CC, de Lima-Seolin BG, Teixeira RB, Poletto Bonetto JH, Colombo R, Schenkel PC, Belló-Klein A, da Rosa Araujo AS. Türck P, et al. Biomed Pharmacother. 2018 Jul;103:182-190. doi: 10.1016/j.biopha.2018.04.001. Epub 2018 Apr 24. Biomed Pharmacother. 2018. PMID: 29653363
METHODS AND RESULTS: Male, 5week-old Wistar rats were divided into four groups: Control, Control + Trapidil, Monocrotaline and Monocrotaline + Trapidil. PAH was induced by an intraperitoneal injection of monocrotaline 60 mg/kg at day 0. ...Trapidil reduced NA …
METHODS AND RESULTS: Male, 5week-old Wistar rats were divided into four groups: Control, Control + Trapidil, Monocrotaline and Monocr …
Trapidil inhibits platelet-derived growth factor-stimulated mitogen-activated protein kinase cascade.
Hoshiya M, Awazu M. Hoshiya M, et al. Hypertension. 1998 Feb;31(2):665-71. doi: 10.1161/01.hyp.31.2.665. Hypertension. 1998. PMID: 9461238
Activation of Raf-1, an upstream activator of MAP kinase, by PDGF was also attenuated by trapidil. Moreover, protein content of MAP kinase phosphatase-1, which inactivates MAP kinase, was elevated in trapidil-treated cells. These actions of trapidil may be me …
Activation of Raf-1, an upstream activator of MAP kinase, by PDGF was also attenuated by trapidil. Moreover, protein content of MAP k …
331 results