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182 results

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Page 1
The CRASH-2 trial: a randomised controlled trial and economic evaluation of the effects of tranexamic acid on death, vascular occlusive events and transfusion requirement in bleeding trauma patients.
Roberts I, Shakur H, Coats T, Hunt B, Balogun E, Barnetson L, Cook L, Kawahara T, Perel P, Prieto-Merino D, Ramos M, Cairns J, Guerriero C. Roberts I, et al. Health Technol Assess. 2013 Mar;17(10):1-79. doi: 10.3310/hta17100. Health Technol Assess. 2013. PMID: 23477634 Free PMC article. Clinical Trial.
MAIN OUTCOME MEASURES: The primary outcome was death in hospital within 4 weeks of injury, and was described with the following categories: bleeding, vascular occlusion (myocardial infarction, stroke and pulmonary embolism), multiorgan failure, head injury …
MAIN OUTCOME MEASURES: The primary outcome was death in hospital within 4 weeks of injury, and was described with the following categ …
Efficacy and safety of tranexamic acid in acute traumatic brain injury: A meta-analysis of randomized controlled trials.
Zhang M, Liu T. Zhang M, et al. Am J Emerg Med. 2024 Jun;80:35-43. doi: 10.1016/j.ajem.2024.03.005. Epub 2024 Mar 13. Am J Emerg Med. 2024. PMID: 38502985 Review.
INTRODUCTION: Tranexamic acid (TXA) holds a pivotal role in the therapeutic approach to traumatic conditions. Nevertheless, its precise influence on diminishing mortality and limiting the progression of intracranial hemorrhage (ICH) during the treatment of traumatic …
INTRODUCTION: Tranexamic acid (TXA) holds a pivotal role in the therapeutic approach to traumatic conditions. Nevertheless, its preci …
Severe Traumatic Brain Injury and Pulmonary Embolism: Risks, Prevention, Diagnosis and Management.
Vrettou CS, Dima E, Karela NR, Sigala I, Korfias S. Vrettou CS, et al. J Clin Med. 2024 Aug 2;13(15):4527. doi: 10.3390/jcm13154527. J Clin Med. 2024. PMID: 39124793 Free PMC article. Review.
Severe traumatic brain injury (sTBI) is a silent epidemic, causing approximately 300,000 intensive care unit (ICU) admissions annually, with a 30% mortality rate. ...We searched PubMed and Scopus for papers published in the last five years that included the t …
Severe traumatic brain injury (sTBI) is a silent epidemic, causing approximately 300,000 intensive care unit (ICU) admi …
Intracranial pressure monitoring with and without brain tissue oxygen pressure monitoring for severe traumatic brain injury in France (OXY-TC): an open-label, randomised controlled superiority trial.
Payen JF, Launey Y, Chabanne R, Gay S, Francony G, Gergele L, Vega E, Montcriol A, Couret D, Cottenceau V, Pili-Floury S, Gakuba C, Hammad E, Audibert G, Pottecher J, Dahyot-Fizelier C, Abdennour L, Gauss T, Richard M, Vilotitch A, Bosson JL, Bouzat P; OXY-TC trial collaborators. Payen JF, et al. Lancet Neurol. 2023 Nov;22(11):1005-1014. doi: 10.1016/S1474-4422(23)00290-9. Lancet Neurol. 2023. PMID: 37863590 Clinical Trial.
INTERPRETATION: After severe non-penetrating traumatic brain injury, intracranial pressure and PbtO(2) monitoring did not reduce the proportion of patients with poor neurological outcome at 6 months. ...Further research is needed to assess whether a targeted …
INTERPRETATION: After severe non-penetrating traumatic brain injury, intracranial pressure and PbtO(2) monitoring did n …
Association of Venous Thromboembolism Prophylaxis After Neurosurgical Intervention for Traumatic Brain Injury With Thromboembolic Complications, Repeated Neurosurgery, and Mortality.
Byrne JP, Witiw CD, Schuster JM, Pascual JL, Cannon JW, Martin ND, Reilly PM, Nathens AB, Seamon MJ. Byrne JP, et al. JAMA Surg. 2022 Mar 1;157(3):e215794. doi: 10.1001/jamasurg.2021.5794. Epub 2022 Mar 9. JAMA Surg. 2022. PMID: 34910096 Free PMC article.
IMPORTANCE: There is a lack of evidence regarding the effectiveness and safety of pharmacologic venous thromboembolism (VTE) prophylaxis among patients who undergo neurosurgical interventions for traumatic brain injury (TBI). OBJECTIVE: To measure the associa …
IMPORTANCE: There is a lack of evidence regarding the effectiveness and safety of pharmacologic venous thromboembolism (VTE) prophylaxis amo …
Therapeutic anticoagulation in patients with traumatic brain injuries and pulmonary emboli.
Chipman AM, Radowsky J, Vesselinov R, Chow D, Schwartzbauer G, Tesoriero R, Stein D. Chipman AM, et al. J Trauma Acute Care Surg. 2020 Sep;89(3):529-535. doi: 10.1097/TA.0000000000002805. J Trauma Acute Care Surg. 2020. PMID: 32467467
Early AC was defined as within 7 days of injury or less; late was defined as after 7 days. Primary outcomes included death, interventions for worsening ICH following AC, and pulmonary complications. Multivariate logistic regression was used to evaluate for clinical …
Early AC was defined as within 7 days of injury or less; late was defined as after 7 days. Primary outcomes included death, intervent …
Fat Embolism Syndrome - A Qualitative Review of its Incidence, Presentation, Pathogenesis and Management.
Timon C, Keady C, Murphy CG. Timon C, et al. Malays Orthop J. 2021 Mar;15(1):1-11. doi: 10.5704/MOJ.2103.001. Malays Orthop J. 2021. PMID: 33880141 Free PMC article. Review.
Fat Embolism Syndrome (FES) is a poorly defined clinical phenomenon which has been attributed to fat emboli entering the circulation. ...Although FES is a multi-system condition, its effects in the lung, brain, cardiovascular system and skin cause most …
Fat Embolism Syndrome (FES) is a poorly defined clinical phenomenon which has been attributed to fat emboli entering the circu …
Treatment of paroxysmal sympathetic hyperactivity.
Rabinstein AA, Benarroch EE. Rabinstein AA, et al. Curr Treat Options Neurol. 2008 Mar;10(2):151-7. doi: 10.1007/s11940-008-0016-y. Curr Treat Options Neurol. 2008. PMID: 18334137
Episodes of paroxysmal sympathetic hyperactivity, sometimes referred to as autonomic storms, are not uncommon in patients with severe traumatic brain injury. Their distinctive characteristics include fever, tachycardia, hypertension, tachypnea, hyperhidrosis, …
Episodes of paroxysmal sympathetic hyperactivity, sometimes referred to as autonomic storms, are not uncommon in patients with severe tra …
Pulmonary embolism in severe traumatic brain injury.
Seifi A, Dengler B, Martinez P, Godoy DA. Seifi A, et al. J Clin Neurosci. 2018 Nov;57:46-50. doi: 10.1016/j.jocn.2018.08.042. Epub 2018 Aug 25. J Clin Neurosci. 2018. PMID: 30154000
INTRODUCTION: Pulmonary emboli (PE) is a significant source of morbidity and mortality in the trauma patients. ...OBJECTIVE: In the present study, we evaluated the incidence of PE in severe traumatic brain injury. METHODS: Retrospective review o …
INTRODUCTION: Pulmonary emboli (PE) is a significant source of morbidity and mortality in the trauma patients. ...OBJECTIVE: I …
When is it safe to resume anticoagulation in traumatic brain injury?
Ng IC, Barnes C, Biswas S, Wright D, Dagal A. Ng IC, et al. Curr Opin Anaesthesiol. 2022 Apr 1;35(2):166-171. doi: 10.1097/ACO.0000000000001117. Curr Opin Anaesthesiol. 2022. PMID: 35131968 Review.
PURPOSE OF REVIEW: When to resume or initiate anticoagulation therapy following traumatic brain injury (TBI) is controversial. This summary describes the latest evidence to guide best practice. RECENT FINDINGS: Following trauma, prophylactic, and therapeutic …
PURPOSE OF REVIEW: When to resume or initiate anticoagulation therapy following traumatic brain injury (TBI) is controv …
182 results