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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1975 1
1977 1
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1980 3
1981 1
1982 1
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1984 9
1985 1
1986 3
1987 5
1988 5
1989 7
1990 8
1991 4
1992 3
1993 4
1994 12
1995 3
1996 2
1997 5
1998 2
1999 8
2000 4
2001 3
2002 1
2003 5
2004 5
2005 3
2006 2
2007 5
2008 6
2009 6
2010 5
2011 6
2012 6
2013 6
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2015 10
2016 4
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2020 13
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233 results

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Filters applied: Meta-Analysis, Randomized Controlled Trial. Clear all
Page 1
Effects of Trazodone on Sleep: A Systematic Review and Meta-analysis.
Kokkali M, Pinioti E, Lappas AS, Christodoulou N, Samara MT. Kokkali M, et al. CNS Drugs. 2024 Oct;38(10):753-769. doi: 10.1007/s40263-024-01110-2. Epub 2024 Aug 9. CNS Drugs. 2024. PMID: 39123094
BACKGROUND AND OBJECTIVES: Sleep problems and insomnia are common, challenging to treat, and transcend specific diagnoses. Although trazodone is a popular choice, robust meta-analytic evidence is lacking. This systematic review and meta-analysis investigates the efficacy a …
BACKGROUND AND OBJECTIVES: Sleep problems and insomnia are common, challenging to treat, and transcend specific diagnoses. Although trazo …
Comparative efficacy and acceptability of 21 antidepressant drugs for the acute treatment of adults with major depressive disorder: a systematic review and network meta-analysis.
Cipriani A, Furukawa TA, Salanti G, Chaimani A, Atkinson LZ, Ogawa Y, Leucht S, Ruhe HG, Turner EH, Higgins JPT, Egger M, Takeshima N, Hayasaka Y, Imai H, Shinohara K, Tajika A, Ioannidis JPA, Geddes JR. Cipriani A, et al. Lancet. 2018 Apr 7;391(10128):1357-1366. doi: 10.1016/S0140-6736(17)32802-7. Epub 2018 Feb 21. Lancet. 2018. PMID: 29477251 Free PMC article.
In head-to-head studies, agomelatine, amitriptyline, escitalopram, mirtazapine, paroxetine, venlafaxine, and vortioxetine were more effective than other antidepressants (range of ORs 1.19-1.96), whereas fluoxetine, fluvoxamine, reboxetine, and trazodone were the least effi …
In head-to-head studies, agomelatine, amitriptyline, escitalopram, mirtazapine, paroxetine, venlafaxine, and vortioxetine were more effectiv …
Trazodone for the treatment of insomnia: a meta-analysis of randomized placebo-controlled trials.
Yi XY, Ni SF, Ghadami MR, Meng HQ, Chen MY, Kuang L, Zhang YQ, Zhang L, Zhou XY. Yi XY, et al. Sleep Med. 2018 May;45:25-32. doi: 10.1016/j.sleep.2018.01.010. Epub 2018 Feb 7. Sleep Med. 2018. PMID: 29680424 Review.
As to secondary efficacy outcomes, we only found a significant reduction for trazodone in NAs (SMD = -0.51, 95%CI -0.97 to -0.05) compared to the placebo, with non-significant differences found in SL, TST, or WASO between trazodone and placebo. ...Trazodone h …
As to secondary efficacy outcomes, we only found a significant reduction for trazodone in NAs (SMD = -0.51, 95%CI -0.97 to -0.05) com …
Trazodone changed the polysomnographic sleep architecture in insomnia disorder: a systematic review and meta-analysis.
Zheng Y, Lv T, Wu J, Lyu Y. Zheng Y, et al. Sci Rep. 2022 Aug 24;12(1):14453. doi: 10.1038/s41598-022-18776-7. Sci Rep. 2022. PMID: 36002579 Free PMC article.
Trazodone has been widely prescribed for off-label use as a sleep aid. Identifying how trazodone impacts the performance of polysomnographic sleep architecture in insomnia disorder will provide additional data that can be used to guide clinical application. To asses …
Trazodone has been widely prescribed for off-label use as a sleep aid. Identifying how trazodone impacts the performance of po …
Comparative effects of pharmacological interventions for the acute and long-term management of insomnia disorder in adults: a systematic review and network meta-analysis.
De Crescenzo F, D'Alò GL, Ostinelli EG, Ciabattini M, Di Franco V, Watanabe N, Kurtulmus A, Tomlinson A, Mitrova Z, Foti F, Del Giovane C, Quested DJ, Cowen PJ, Barbui C, Amato L, Efthimiou O, Cipriani A. De Crescenzo F, et al. Lancet. 2022 Jul 16;400(10347):170-184. doi: 10.1016/S0140-6736(22)00878-9. Lancet. 2022. PMID: 35843245 Free article.
Many licensed drugs (including benzodiazepines, daridorexant, suvorexant, and trazodone) can be effective in the acute treatment of insomnia but are associated with poor tolerability, or information about long-term effects is not available. ...
Many licensed drugs (including benzodiazepines, daridorexant, suvorexant, and trazodone) can be effective in the acute treatment of i …
Trazodone for erectile dysfunction: a systematic review and meta-analysis.
Fink HA, MacDonald R, Rutks IR, Wilt TJ. Fink HA, et al. BJU Int. 2003 Sep;92(4):441-6. doi: 10.1046/j.1464-410x.2003.04358.x. BJU Int. 2003. PMID: 12930437
Subgroup analyses suggested that men with psychogenic ED might be more likely to benefit from trazodone than those with mixed or physiological ED. The efficacy of trazodone also appeared greater at higher doses (150-200 vs 50 mg/day). ...Specific adverse events with …
Subgroup analyses suggested that men with psychogenic ED might be more likely to benefit from trazodone than those with mixed or phys …
Antidepressants for insomnia in adults.
Everitt H, Baldwin DS, Stuart B, Lipinska G, Mayers A, Malizia AL, Manson CC, Wilson S. Everitt H, et al. Cochrane Database Syst Rev. 2018 May 14;5(5):CD010753. doi: 10.1002/14651858.CD010753.pub2. Cochrane Database Syst Rev. 2018. PMID: 29761479 Free PMC article.
Other' antidepressants with placebo: eight studies compared other antidepressants with placebo (one used mianserin and seven used trazodone). Three studies (370 participants) of trazodone could be pooled, indicating a moderate improvement in subjective sleep outcome …
Other' antidepressants with placebo: eight studies compared other antidepressants with placebo (one used mianserin and seven used trazodo …
The comparative efficacy of trazodone and imipramine in the treatment of depression.
Patten SB. Patten SB. CMAJ. 1992 Apr 1;146(7):1177-82. CMAJ. 1992. PMID: 1532532 Free PMC article.
DATA EXTRACTION: All six studies compared trazodone with imipramine. Data describing response to the treatments were extracted, and post-hoc power estimates were calculated. ...The results of statistical tests of the modified null hypothesis, inspection of the CIs and the …
DATA EXTRACTION: All six studies compared trazodone with imipramine. Data describing response to the treatments were extracted, and p …
Safety and efficacy of memantine and trazodone versus placebo for motor neuron disease (MND SMART): stage two interim analysis from the first cycle of a phase 3, multiarm, multistage, randomised, adaptive platform trial.
Pal S, Chataway J, Swingler R, Macleod MR, Carragher NO, Hardingham G, Selvaraj BT, Smith C, Wong C, Newton J, Lyle D, Stenson A, Dakin RS, Ihenacho A, Colville S, Mehta AR, Stallard N, Carpenter JR, Parker RA, Keerie C, Weir CJ, Virgo B, Morris S, Waters N, Gray B, MacDonald D, MacDonald E, Parmar MKB, Chandran S; MND SMART Investigators. Pal S, et al. Lancet Neurol. 2024 Nov;23(11):1097-1107. doi: 10.1016/S1474-4422(24)00326-0. Epub 2024 Sep 19. Lancet Neurol. 2024. PMID: 39307154 Free article. Clinical Trial.
The one-sided p values were both above the significance threshold of 10%, indicating that neither memantine nor trazodone groups met the criteria for continuation. There were 483 participants with at least one adverse event (145 [77%] on placebo, 170 [91%] on memantine, an …
The one-sided p values were both above the significance threshold of 10%, indicating that neither memantine nor trazodone groups met …
Pharmacotherapies for sleep disturbances in dementia.
McCleery J, Sharpley AL. McCleery J, et al. Cochrane Database Syst Rev. 2020 Nov 15;11(11):CD009178. doi: 10.1002/14651858.CD009178.pub4. Cochrane Database Syst Rev. 2020. PMID: 33189083 Free PMC article.
Participants in the trazodone study and most participants in the melatonin studies had moderate-to-severe dementia due to Alzheimer's disease (AD); those in the ramelteon study and the orexin antagonist studies had mild-to-moderate AD. ...There were no serious adverse effe …
Participants in the trazodone study and most participants in the melatonin studies had moderate-to-severe dementia due to Alzheimer's …
233 results