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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1983 2
1986 1
1987 2
1988 2
1989 3
1990 5
1991 2
1992 2
1994 7
1995 4
1996 1
1997 5
1998 1
1999 4
2000 2
2001 5
2002 3
2003 5
2004 9
2005 14
2006 13
2007 12
2008 9
2009 9
2010 10
2011 12
2012 10
2013 8
2014 6
2015 11
2016 11
2017 14
2018 17
2019 14
2020 21
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2022 22
2023 34
2024 18
2025 34

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364 results

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Page 1
Trazodone for Insomnia: A Systematic Review.
Jaffer KY, Chang T, Vanle B, Dang J, Steiner AJ, Loera N, Abdelmesseh M, Danovitch I, Ishak WW. Jaffer KY, et al. Innov Clin Neurosci. 2017 Aug 1;14(7-8):24-34. eCollection 2017 Jul-Aug. Innov Clin Neurosci. 2017. PMID: 29552421 Free PMC article. Review.
In this systematic review, we examined the evidence for the efficacy and safety of trazodone for insomnia. METHODS: A literature search was conducted using MEDLINE/PubMed databases from the past 33 years (1983-2016) and the keywords insomnia, trazodone …
In this systematic review, we examined the evidence for the efficacy and safety of trazodone for insomnia. METHODS: A literatu …
Treatment of insomnia - effect of trazodone and hypnotics on sleep.
Wichniak A, Wierzbicka AE, Jarema M. Wichniak A, et al. Psychiatr Pol. 2021 Aug 31;55(4):743-755. doi: 10.12740/PP/125650. Epub 2021 Aug 31. Psychiatr Pol. 2021. PMID: 34994734 Free article. Review. English, Polish.
Sedative antidepressants are commonly used drugs in the treatment of insomnia. However, some recommendations claim that only hypnotics have been proven effective in the treatment of sleep initiation and maintenance disorders. ...In the tr …
Sedative antidepressants are commonly used drugs in the treatment of insomnia. However, some recommendations claim that only hypnotic …
Comparative effects of pharmacological interventions for the acute and long-term management of insomnia disorder in adults: a systematic review and network meta-analysis.
De Crescenzo F, D'Alò GL, Ostinelli EG, Ciabattini M, Di Franco V, Watanabe N, Kurtulmus A, Tomlinson A, Mitrova Z, Foti F, Del Giovane C, Quested DJ, Cowen PJ, Barbui C, Amato L, Efthimiou O, Cipriani A. De Crescenzo F, et al. Lancet. 2022 Jul 16;400(10347):170-184. doi: 10.1016/S0140-6736(22)00878-9. Lancet. 2022. PMID: 35843245 Free article.
BACKGROUND: Behavioural, cognitive, and pharmacological interventions can all be effective for insomnia. However, because of inadequate resources, medications are more frequently used worldwide. ...Many licensed drugs (including benzodiazepines, daridorexant, suvorexant, a …
BACKGROUND: Behavioural, cognitive, and pharmacological interventions can all be effective for insomnia. However, because of inadequa …
Insomnia in Elderly Patients: Recommendations for Pharmacological Management.
Abad VC, Guilleminault C. Abad VC, et al. Drugs Aging. 2018 Sep;35(9):791-817. doi: 10.1007/s40266-018-0569-8. Drugs Aging. 2018. PMID: 30058034 Review.
Ramelteon or short-acting Z-drugs can treat sleep-onset insomnia. Suvorexant or low-dose doxepin can improve sleep maintenance. Eszopiclone or zolpidem extended release can be utilized for both sleep onset and sleep maintenance. .. …
Ramelteon or short-acting Z-drugs can treat sleep-onset insomnia. Suvorexant or low-dose doxepin can improve sleep m …
Should Trazodone Be First-Line Therapy for Insomnia? A Clinical Suitability Appraisal.
Pelayo R, Bertisch SM, Morin CM, Winkelman JW, Zee PC, Krystal AD. Pelayo R, et al. J Clin Med. 2023 Apr 18;12(8):2933. doi: 10.3390/jcm12082933. J Clin Med. 2023. PMID: 37109268 Free PMC article. Review.
Trazodone is one of the most commonly used prescription medications for insomnia; however, some recent clinical guidelines do not recommend its use for treating insomnia. This clinical appraisal critically reviews the scientific literature on trazodone …
Trazodone is one of the most commonly used prescription medications for insomnia; however, some recent clinical guidelines do …
Drugs for Insomnia beyond Benzodiazepines: Pharmacology, Clinical Applications, and Discovery.
Atkin T, Comai S, Gobbi G. Atkin T, et al. Pharmacol Rev. 2018 Apr;70(2):197-245. doi: 10.1124/pr.117.014381. Pharmacol Rev. 2018. PMID: 29487083 Review.
There is evidence to recommend suvorexant and low-dose doxepin for sleep maintenance insomnia; there is also sufficient evidence to recommend ramelteon for sleep onset insomnia. Although there is limited evidence for the use of the quetiapine, …
There is evidence to recommend suvorexant and low-dose doxepin for sleep maintenance insomnia; there is also sufficient …
Clinical Practice Guideline for the Pharmacologic Treatment of Chronic Insomnia in Adults: An American Academy of Sleep Medicine Clinical Practice Guideline.
Sateia MJ, Buysse DJ, Krystal AD, Neubauer DN, Heald JL. Sateia MJ, et al. J Clin Sleep Med. 2017 Feb 15;13(2):307-349. doi: 10.5664/jcsm.6470. J Clin Sleep Med. 2017. PMID: 27998379 Free PMC article.
(WEAK). We suggest that clinicians not use trazodone as a treatment for sleep onset or sleep maintenance insomnia (versus no treatment) in adults. ...We suggest that clinicians not use melatonin as a treatment for sleep onset or sleep …
(WEAK). We suggest that clinicians not use trazodone as a treatment for sleep onset or sleep maintenance inso …
Trazodone for the treatment of insomnia: a meta-analysis of randomized placebo-controlled trials.
Yi XY, Ni SF, Ghadami MR, Meng HQ, Chen MY, Kuang L, Zhang YQ, Zhang L, Zhou XY. Yi XY, et al. Sleep Med. 2018 May;45:25-32. doi: 10.1016/j.sleep.2018.01.010. Epub 2018 Feb 7. Sleep Med. 2018. PMID: 29680424 Review.
Moreover, no significant difference was found in the outcome of tolerability or acceptability. CONCLUSIONS: Trazodone was effective in sleep maintenance by decreasing the number of early awakenings and it could significantly improve perceived sleep qua …
Moreover, no significant difference was found in the outcome of tolerability or acceptability. CONCLUSIONS: Trazodone was effective i …
Trazodone: Insomnia (Adults).
Generali JA, Cada DJ. Generali JA, et al. Hosp Pharm. 2015 May;50(5):367-9. doi: 10.1310/hpj5005-367. Hosp Pharm. 2015. PMID: 26405321 Free PMC article.
Trazodone changed the polysomnographic sleep architecture in insomnia disorder: a systematic review and meta-analysis.
Zheng Y, Lv T, Wu J, Lyu Y. Zheng Y, et al. Sci Rep. 2022 Aug 24;12(1):14453. doi: 10.1038/s41598-022-18776-7. Sci Rep. 2022. PMID: 36002579 Free PMC article.
Trazodone has been widely prescribed for off-label use as a sleep aid. Identifying how trazodone impacts the performance of polysomnographic sleep architecture in insomnia disorder will provide additional data that can be used to guide clinical …
Trazodone has been widely prescribed for off-label use as a sleep aid. Identifying how trazodone impacts the performanc …
364 results