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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1925 1
1931 1
1934 2
1935 1
1938 1
1940 1
1944 1
1948 1
1949 2
1952 1
1956 2
1957 2
1958 5
1959 7
1960 4
1961 5
1962 6
1963 5
1964 12
1965 12
1966 7
1967 15
1968 14
1969 20
1970 15
1971 18
1972 22
1973 34
1974 55
1975 58
1976 54
1977 34
1978 35
1979 41
1980 37
1981 29
1982 41
1983 39
1984 43
1985 59
1986 67
1987 54
1988 63
1989 72
1990 70
1991 84
1992 77
1993 92
1994 104
1995 102
1996 133
1997 151
1998 151
1999 147
2000 190
2001 194
2002 195
2003 204
2004 221
2005 255
2006 271
2007 348
2008 337
2009 349
2010 350
2011 367
2012 438
2013 462
2014 479
2015 456
2016 449
2017 483
2018 510
2019 574
2020 535
2021 2
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8,900 results
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Page 1
Trehalose metabolism in plants.
Lunn JE, Delorge I, Figueroa CM, Van Dijck P, Stitt M. Lunn JE, et al. Plant J. 2014 Aug;79(4):544-67. doi: 10.1111/tpj.12509. Epub 2014 May 21. Plant J. 2014. PMID: 24645920 Free article. Review.
These functions have largely been replaced by sucrose in vascular plants, and trehalose metabolism has taken on new roles. Trehalose is a potential signal metabolite in plant interactions with pathogenic or symbiotic micro-organisms and herbivorous insects. ...In pl …
These functions have largely been replaced by sucrose in vascular plants, and trehalose metabolism has taken on new roles. Trehalo
Trehalose in ophthalmology.
Cejka C, Kubinova S, Cejkova J. Cejka C, et al. Histol Histopathol. 2019 Jun;34(6):611-618. doi: 10.14670/HH-18-082. Epub 2019 Jan 9. Histol Histopathol. 2019. PMID: 30623968 Review.
Trehalose, a disaccharide of glucose, is a naturally occurring nontoxic and nonreducing bioactive sugar. Trehalose is synthetized by many organisms when cells are exposed to stressful conditions, including dehydration, heat, oxidation, hypoxia or even anoxia. ...
Trehalose, a disaccharide of glucose, is a naturally occurring nontoxic and nonreducing bioactive sugar. Trehalose is syntheti
Mechanism of neuroprotection by trehalose: controversy surrounding autophagy induction.
Lee HJ, Yoon YS, Lee SJ. Lee HJ, et al. Cell Death Dis. 2018 Jun 15;9(7):712. doi: 10.1038/s41419-018-0749-9. Cell Death Dis. 2018. PMID: 29907758 Free PMC article. Review.
The mechanism underlying the neuroprotective effects of trehalose remains elusive. The prevailing hypothesis is that trehalose protects neurons by inducing autophagy, thereby clearing protein aggregates. ...Furthermore, a recent study with a thorough examination of …
The mechanism underlying the neuroprotective effects of trehalose remains elusive. The prevailing hypothesis is that trehalose
Using trehalose to prevent and treat metabolic function: effectiveness and mechanisms.
Zhang Y, DeBosch BJ. Zhang Y, et al. Curr Opin Clin Nutr Metab Care. 2019 Jul;22(4):303-310. doi: 10.1097/MCO.0000000000000568. Curr Opin Clin Nutr Metab Care. 2019. PMID: 31033580 Review.
PURPOSE OF REVIEW: Trehalose is a disaccharide with manifold industrial, commercial and biomedical uses. In the decade following its initial definition as an autophagy-inducing agent, significant advances have been realized in regard to the applicable clinical and preclini …
PURPOSE OF REVIEW: Trehalose is a disaccharide with manifold industrial, commercial and biomedical uses. In the decade following its …
Trehalose in Water Revisited.
Soper AK, Ricci MA, Bruni F, Rhys NH, McLain SE. Soper AK, et al. J Phys Chem B. 2018 Jul 26;122(29):7365-7374. doi: 10.1021/acs.jpcb.8b03450. Epub 2018 Jul 17. J Phys Chem B. 2018. PMID: 29965765
In the first study, which looks at two concentrations of trehalose-water mole ratios of 1:100 and 1:25, the conclusion is that trehalose hydrogen-bonds to water rather weakly and has a relatively minor impact on the structure of water in solution compared to bulk wa …
In the first study, which looks at two concentrations of trehalose-water mole ratios of 1:100 and 1:25, the conclusion is that tre
Trehalose: a review of properties, history of use and human tolerance, and results of multiple safety studies.
Richards AB, Krakowka S, Dexter LB, Schmid H, Wolterbeek AP, Waalkens-Berendsen DH, Shigoyuki A, Kurimoto M. Richards AB, et al. Food Chem Toxicol. 2002 Jul;40(7):871-98. doi: 10.1016/s0278-6915(02)00011-x. Food Chem Toxicol. 2002. PMID: 12065209 Review.
Trehalose (alpha,alpha-trehalose) is a naturally occurring sugar containing two D-glucose units in an alpha,alpha-1,1 linkage. ...On the basis of these toxicity studies, human studies in which doses of trehalose were administered to various populations, and c
Trehalose (alpha,alpha-trehalose) is a naturally occurring sugar containing two D-glucose units in an alpha,alpha-1,1 linkage.
Trehalose 6-phosphate.
Paul M. Paul M. Curr Opin Plant Biol. 2007 Jun;10(3):303-9. doi: 10.1016/j.pbi.2007.04.001. Epub 2007 Apr 16. Curr Opin Plant Biol. 2007. PMID: 17434789 Review.
Its significance began to dawn when genetic modification of the trehalose pathway produced dramatic phenotypes, before the genetic proliferation of the trehalose pathway in plants was fully realised. ...Trehalose phosphate synthases (TPSs) and trehalose
Its significance began to dawn when genetic modification of the trehalose pathway produced dramatic phenotypes, before the genetic pr …
Degradation-resistant trehalose analogues block utilization of trehalose by hypervirulent Clostridioides difficile.
Danielson ND , Collins J , Stothard AI , Dong QQ , Kalera K , Woodruff PJ , DeBosch BJ , Britton RA , Swarts BM . Danielson ND , et al. Chem Commun (Camb). 2019 Apr 23;55(34):5009-5012. doi: 10.1039/c9cc01300h. Chem Commun (Camb). 2019. PMID: 30968891 Free PMC article.
Furthermore, we demonstrate that trehalose analogues, but not the known trehalase inhibitor validamycin A, inhibit native trehalose utilization by hypervirulent C. difficile. Thus, degradation-resistant trehalose analogues are valuable as trehalase inhibitors …
Furthermore, we demonstrate that trehalose analogues, but not the known trehalase inhibitor validamycin A, inhibit native trehalos
Trehalose Analogues: Latest Insights in Properties and Biocatalytic Production.
Walmagh M, Zhao R, Desmet T. Walmagh M, et al. Int J Mol Sci. 2015 Jun 15;16(6):13729-45. doi: 10.3390/ijms160613729. Int J Mol Sci. 2015. PMID: 26084050 Free PMC article. Review.
Trehalose analogues, like lactotrehalose (α-D-glucopyranosyl α-D-galactopyranoside) or galactotrehalose (α-D-galactopyranosyl α-D-galactopyranoside), offer similar benefits as trehalose, but show additional features such as prebiotic or low-calorie sweetener due to
Trehalose analogues, like lactotrehalose (α-D-glucopyranosyl α-D-galactopyranoside) or galactotrehalose (α-D-galactopyranosyl α-D-gal
Glucose-Responsive Trehalose Hydrogel for Insulin Stabilization and Delivery.
Lee J, Ko JH, Mansfield KM, Nauka PC, Bat E, Maynard HD. Lee J, et al. Macromol Biosci. 2018 May;18(5):e1700372. doi: 10.1002/mabi.201700372. Epub 2018 Apr 17. Macromol Biosci. 2018. PMID: 29665232 Free PMC article.
Herein, a trehalose-based hydrogel is reported that stabilizes insulin to elevated temperatures prior to glucose-triggered release. ...The hydroxyls of the trehalose side chains form boronate ester linkages with the PEG boronic acid cross-linker to yield hydrogels w …
Herein, a trehalose-based hydrogel is reported that stabilizes insulin to elevated temperatures prior to glucose-triggered release. . …
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