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Page 1
Drug-induced Brugada syndrome.
Yap YG, Behr ER, Camm AJ. Yap YG, et al. Europace. 2009 Aug;11(8):989-94. doi: 10.1093/europace/eup114. Epub 2009 May 29. Europace. 2009. PMID: 19482855 Free article. Review.
However, recently, many other pharmacological agents not related to class I anti-arrhythmic agents have been reported to induce Brugada ECG patterns including tricyclic antidepressants, fluoxetine, lithium, trifluoperazine, antihistamines, and cocaine. As published reports …
However, recently, many other pharmacological agents not related to class I anti-arrhythmic agents have been reported to induce Brugada ECG …
Treating hearts and minds: adverse cardiovascular effects of psychiatric medications.
Raja AS, Leslie SJ, Buist E, Rushworth GF, Megson IL, McNamara N. Raja AS, et al. Ther Adv Drug Saf. 2026 Mar 29;17:20420986261418947. doi: 10.1177/20420986261418947. eCollection 2026. Ther Adv Drug Saf. 2026. PMID: 41918925 Free PMC article. Review.
These adverse effects include QTc prolongation and torsades de pointes (TdP), which are phenomena associated with certain selective serotonin reuptake inhibitors (SSRIs), tricyclic antidepressants (TCAs) and antipsychotics. Increasing QT dispersion and induction of …
These adverse effects include QTc prolongation and torsades de pointes (TdP), which are phenomena associated with certain selective s …
Drug-induced torsade de pointes.
Raehl CL, Patel AK, LeRoy M. Raehl CL, et al. Clin Pharm. 1985 Nov-Dec;4(6):675-90. Clin Pharm. 1985. PMID: 2416504 Review.
No additional episodes of torsade de pointes have been observed. Torsade de pointes is characterized by polymorphous electrocardiographic appearance and delayed repolarization (prolonged QT interval). ...Periodic serum electrolyte assessment is warranted, and …
No additional episodes of torsade de pointes have been observed. Torsade de pointes is characterized by polymorphous electroca …
Prolonged QT Risk Assessment in Antipsychotic Overdose Using the QT Nomogram.
Berling I, Isbister GK. Berling I, et al. Ann Emerg Med. 2015 Aug;66(2):154-64. doi: 10.1016/j.annemergmed.2014.12.005. Epub 2015 Jan 30. Ann Emerg Med. 2015. PMID: 25639523
STUDY OBJECTIVE: Antipsychotic drugs are frequently reported to cause QT prolongation and torsade de pointes. We aim to investigate the potential risk of torsade de pointes in antipsychotic overdose by assessing the QT interval with the QT nomog …
STUDY OBJECTIVE: Antipsychotic drugs are frequently reported to cause QT prolongation and torsade de pointes. We aim to invest …
Cardiotoxicity more common in thioridazine overdose than with other neuroleptics.
Buckley NA, Whyte IM, Dawson AH. Buckley NA, et al. J Toxicol Clin Toxicol. 1995;33(3):199-204. doi: 10.3109/15563659509017984. J Toxicol Clin Toxicol. 1995. PMID: 7760442
The main outcome measures examined were ECG changes (QRS, QT and QTc intervals), arrhythmias, seizures, degree of sedation, heart rate and blood pressure. Two-hundred ninety-nine patients had ingested thioridazine (104), chlorpromazine (69), trifluoperazine (36), pe …
The main outcome measures examined were ECG changes (QRS, QT and QTc intervals), arrhythmias, seizures, degree of sedation, heart rat …
THE EFFECT OF PHENOTHIAZINES ON THE ELECTROCARDIOGRAM.
BAN TA, STJEAN A. BAN TA, et al. Can Med Assoc J. 1964 Sep 5;91(10):537-40. Can Med Assoc J. 1964. PMID: 14176059 Free PMC article.
Thioridazine, chlorpromazine and trifluoperazine were administered to six psychiatric patients. Each was used in four dosage levels (thioridazine and chlorpromazine: 200, 400, 800 and 1200 mg. daily; trifluoperazine: 8, 16, 32, 64 mg. daily); and each increase in do …
Thioridazine, chlorpromazine and trifluoperazine were administered to six psychiatric patients. Each was used in four dosage levels ( …
First generation antipsychotic-associated serious adverse events in women: a retrospective analysis of a pharmacovigilance database.
McCall KL, Doughty BJ, Piper BJ, Naik H, Bange S, Leppien EE. McCall KL, et al. Int J Clin Pharm. 2024 Apr;46(2):515-521. doi: 10.1007/s11096-023-01693-8. Epub 2024 Feb 5. Int J Clin Pharm. 2024. PMID: 38315306
The study cohort consisted of chlorpromazine (n = 3317), fluphenazine (n = 1124), haloperidol (n = 16,709), loxapine (n = 3151), perphenazine (n = 816), thioridazine (n = 665), thiothixene (n = 244), and trifluoperazine (n = 360). Cases of neuroleptic malignant syndrome (N …
The study cohort consisted of chlorpromazine (n = 3317), fluphenazine (n = 1124), haloperidol (n = 16,709), loxapine (n = 3151), perphenazin …
Inhibition of human ether-a-go-go-related gene K+ channel and IKr of guinea pig cardiomyocytes by antipsychotic drug trifluoperazine.
Choi SY, Koh YS, Jo SH. Choi SY, et al. J Pharmacol Exp Ther. 2005 May;313(2):888-95. doi: 10.1124/jpet.104.080853. Epub 2005 Feb 18. J Pharmacol Exp Ther. 2005. PMID: 15722405
Trifluoperazine, a commonly used antipsychotic drug, has been known to induce QT prolongation and torsades de pointes, which can cause sudden death. ...The application of trifluoperazine showed a dose-dependent decrease in current amplitudes at the end …
Trifluoperazine, a commonly used antipsychotic drug, has been known to induce QT prolongation and torsades de pointes, …
Proarrhythmic effects of antidepressants and neuroleptic drugs on isolated, spontaneously beating guinea-pig Purkinje fibers.
Studenik C, Lemmens-Gruber R, Heistracher P. Studenik C, et al. Eur J Pharm Sci. 1999 Jan;7(2):113-8. doi: 10.1016/s0928-0987(98)00013-x. Eur J Pharm Sci. 1999. PMID: 9845790
Antidepressants and neuroleptic drugs are sometimes the reason for the occurrence of the polymorphic ventricular arrhythmia torsades de pointes in patients. Therefore, it was of interest to study the actions of some of these drugs such as imipramine, amitriptyline, doxepin …
Antidepressants and neuroleptic drugs are sometimes the reason for the occurrence of the polymorphic ventricular arrhythmia torsades …