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Conservation of structure and mechanism by Trm5 enzymes.
Christian T, Gamper H, Hou YM. Christian T, et al. RNA. 2013 Sep;19(9):1192-9. doi: 10.1261/rna.039503.113. Epub 2013 Jul 25. RNA. 2013. PMID: 23887145 Free PMC article.
The successful targeting of TrmD requires detailed information on Trm5 to avoid cross-species inhibition. However, most information on Trm5 is derived from studies of the archaeal enzyme Methanococcus jannaschii (MjTrm5), whereas little information is available for …
The successful targeting of TrmD requires detailed information on Trm5 to avoid cross-species inhibition. However, most information o …
Kinetic Analysis of tRNA Methyltransferases.
Hou YM, Masuda I. Hou YM, et al. Methods Enzymol. 2015;560:91-116. doi: 10.1016/bs.mie.2015.04.012. Epub 2015 Jun 2. Methods Enzymol. 2015. PMID: 26253967 Free PMC article.
A remarkable methylation is to the G37 base on the 3'-side of the anticodon to generate m(1)G37-tRNA, which suppresses frameshift errors during protein synthesis and is therefore essential for cell growth in all three domains of life. This methylation is catalyzed by TrmD in bact …
A remarkable methylation is to the G37 base on the 3'-side of the anticodon to generate m(1)G37-tRNA, which suppresses frameshift errors dur …
Isolation and characterization of the human tRNA-(N1G37) methyltransferase (TRM5) and comparison to the Escherichia coli TrmD protein.
Brulé H, Elliott M, Redlak M, Zehner ZE, Holmes WM. Brulé H, et al. Biochemistry. 2004 Jul 20;43(28):9243-55. doi: 10.1021/bi049671q. Biochemistry. 2004. PMID: 15248782
A human TRM5 cDNA has been cloned and recombinant tRNA-N(1)G37 methyltransferase was produced. ...TRM5 demonstrates much higher affinity for substrates with K(m) values for tRNA that are nanomolar. ...
A human TRM5 cDNA has been cloned and recombinant tRNA-N(1)G37 methyltransferase was produced. ...TRM5 demonstrates much highe …
Distinct determinants of tRNA recognition by the TrmD and Trm5 methyl transferases.
Christian T, Hou YM. Christian T, et al. J Mol Biol. 2007 Oct 26;373(3):623-32. doi: 10.1016/j.jmb.2007.08.010. Epub 2007 Aug 21. J Mol Biol. 2007. PMID: 17868690 Free PMC article.
TrmD and Trm5 are, respectively, the bacterial and eukarya/archaea methyl transferases that catalyze transfer of the methyl group from S-adenosyl methionine (AdoMet) to the N1 position of G37 in tRNA to synthesize m1G37-tRNA. The m1G37 modification prevents tRNA frameshift …
TrmD and Trm5 are, respectively, the bacterial and eukarya/archaea methyl transferases that catalyze transfer of the methyl group fro …
Crystal structure of archaeal tRNA(m(1)G37)methyltransferase aTrm5.
Goto-Ito S, Ito T, Ishii R, Muto Y, Bessho Y, Yokoyama S. Goto-Ito S, et al. Proteins. 2008 Sep;72(4):1274-89. doi: 10.1002/prot.22019. Proteins. 2008. PMID: 18384044
In archaea and eukaryotes, m(1)G37 synthesis is catalyzed by tRNA(m(1)G37)methyltransferase (archaeal or eukaryotic Trm5, a/eTrm5). Here we report the crystal structure of archaeal Trm5 (aTrm5) from Methanocaldococcus jannaschii (formerly known as Methanococcus jann …
In archaea and eukaryotes, m(1)G37 synthesis is catalyzed by tRNA(m(1)G37)methyltransferase (archaeal or eukaryotic Trm5, a/eTrm5). H …
Discovery and validation of a prognostic proteomic signature for tuberculosis progression: A prospective cohort study.
Penn-Nicholson A, Hraha T, Thompson EG, Sterling D, Mbandi SK, Wall KM, Fisher M, Suliman S, Shankar S, Hanekom WA, Janjic N, Hatherill M, Kaufmann SHE, Sutherland J, Walzl G, De Groote MA, Ochsner U, Zak DE, Scriba TJ; ACS and GC6–74 cohort study groups. Penn-Nicholson A, et al. PLoS Med. 2019 Apr 16;16(4):e1002781. doi: 10.1371/journal.pmed.1002781. eCollection 2019 Apr. PLoS Med. 2019. PMID: 30990820 Free PMC article.
Three hundred sixty-one proteins of differential abundance between progressors and nonprogressors were identified. A 5-protein signature, TB Risk Model 5 (TRM5), was discovered in the ACS training set and verified by blind prediction in the ACS test set. ...TRM5 val …
Three hundred sixty-one proteins of differential abundance between progressors and nonprogressors were identified. A 5-protein signature, TB …
Selective inhibitors of bacterial t-RNA-(N(1)G37) methyltransferase (TrmD) that demonstrate novel ordering of the lid domain.
Hill PJ, Abibi A, Albert R, Andrews B, Gagnon MM, Gao N, Grebe T, Hajec LI, Huang J, Livchak S, Lahiri SD, McKinney DC, Thresher J, Wang H, Olivier N, Buurman ET. Hill PJ, et al. J Med Chem. 2013 Sep 26;56(18):7278-88. doi: 10.1021/jm400718n. Epub 2013 Sep 17. J Med Chem. 2013. PMID: 23981144
Additionally, TrmD is very distinct from its human orthologue TRM5 and thus is a suitable target for the design of novel antibacterials. ...
Additionally, TrmD is very distinct from its human orthologue TRM5 and thus is a suitable target for the design of novel antibacteria …