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Structure of tRNA methyltransferase complex of Trm7 and Trm734 reveals a novel binding interface for tRNA recognition.
Hirata A, Okada K, Yoshii K, Shiraishi H, Saijo S, Yonezawa K, Shimizu N, Hori H. Hirata A, et al. Nucleic Acids Res. 2019 Nov 18;47(20):10942-10955. doi: 10.1093/nar/gkz856. Nucleic Acids Res. 2019. PMID: 31586407 Free PMC article.
The complex between Trm7 and Trm734 (Trm7-Trm734) from Saccharomyces cerevisiae catalyzes 2'-O-methylation at position 34 in tRNA. ...BPA and BPC form a unique V-shaped cleft, which docks to Trm7. The C-terminal region of Trm7 is required for binding t …
The complex between Trm7 and Trm734 (Trm7-Trm734) from Saccharomyces cerevisiae catalyzes 2'-O-methylation at position 34 in t …
Yeast Trm7 interacts with distinct proteins for critical modifications of the tRNAPhe anticodon loop.
Guy MP, Podyma BM, Preston MA, Shaheen HH, Krivos KL, Limbach PA, Hopper AK, Phizicky EM. Guy MP, et al. RNA. 2012 Oct;18(10):1921-33. doi: 10.1261/rna.035287.112. Epub 2012 Aug 21. RNA. 2012. PMID: 22912484 Free PMC article.
Post-transcriptional modification of the tRNA anticodon loop is critical for translation. Yeast Trm7 is required for 2'-O-methylation of C(32) and N(34) of tRNA(Phe), tRNA(Trp), and tRNA(Leu(UAA)) to form Cm(32) and Nm(34), and trm7-delta mutants have severe growth …
Post-transcriptional modification of the tRNA anticodon loop is critical for translation. Yeast Trm7 is required for 2'-O-methylation …
Identification of a Trm732 Motif Required for 2'-O-methylation of the tRNA Anticodon Loop by Trm7.
Funk HM, DiVita DJ, Sizemore HE, Wehrle K, Miller CLW, Fraley ME, Mullins AK, Guy AR, Phizicky EM, Guy MP. Funk HM, et al. ACS Omega. 2022 Apr 13;7(16):13667-13675. doi: 10.1021/acsomega.1c07231. eCollection 2022 Apr 26. ACS Omega. 2022. PMID: 35559166 Free PMC article.
Throughout eukaryotes, 2'-O-methylation of residues 32 and 34 of the anticodon loop of tRNA is important for proper translation, and in humans, a lack of these modifications results in non-syndromic X-linked intellectual disability. In yeast, the methyltransferase Trm7 for …
Throughout eukaryotes, 2'-O-methylation of residues 32 and 34 of the anticodon loop of tRNA is important for proper translation, and in huma …
tRNA 2'-O-methylation by a duo of TRM7/FTSJ1 proteins modulates small RNA silencing in Drosophila.
Angelova MT, Dimitrova DG, Da Silva B, Marchand V, Jacquier C, Achour C, Brazane M, Goyenvalle C, Bourguignon-Igel V, Shehzada S, Khouider S, Lence T, Guerineau V, Roignant JY, Antoniewski C, Teysset L, Bregeon D, Motorin Y, Schaefer MR, Carré C. Angelova MT, et al. Nucleic Acids Res. 2020 Feb 28;48(4):2050-2072. doi: 10.1093/nar/gkaa002. Nucleic Acids Res. 2020. PMID: 31943105 Free PMC article.
Here, we identify two Nm methyltransferases (Nm-MTases) in Drosophila melanogaster (CG7009 and CG5220) as functional orthologs of yeast TRM7 and human FTSJ1. Genetic knockout studies together with MALDI-TOF mass spectrometry and RiboMethSeq mapping revealed that CG7009 is …
Here, we identify two Nm methyltransferases (Nm-MTases) in Drosophila melanogaster (CG7009 and CG5220) as functional orthologs of yeast T …
Two-subunit enzymes involved in eukaryotic post-transcriptional tRNA modification.
Guy MP, Phizicky EM. Guy MP, et al. RNA Biol. 2014;11(12):1608-18. doi: 10.1080/15476286.2015.1008360. RNA Biol. 2014. PMID: 25625329 Free PMC article. Review.
These enzymes include the deaminase Tad2-Tad3, and the methyltransferases Trm6-Trm61, Trm8-Trm82, Trm7-Trm732, and Trm7-Trm734, Trm9-Trm112, and Trm11-Trm112. We describe the occurrence and biological role of each modification, evidence for a required partner protei …
These enzymes include the deaminase Tad2-Tad3, and the methyltransferases Trm6-Trm61, Trm8-Trm82, Trm7-Trm732, and Trm7-Trm734 …
Identification of Amino Acids in Trm734 Required for 2'-O-Methylation of the tRNAPhe Wobble Residue.
Funk HM, Brooks JH, Detmer AE, Creech NN, Guy MP. Funk HM, et al. ACS Omega. 2024 Jun 3;9(23):25063-25072. doi: 10.1021/acsomega.4c02313. eCollection 2024 Jun 11. ACS Omega. 2024. PMID: 38882062 Free PMC article.
In yeast, Cm(32) is formed by an enzyme that consists of the methyltransferase Trm7 in complex with the auxiliary protein Trm732, and Gm(34) is formed by an enzyme that consists of Trm7 in complex with Trm734. ...Based on the previously determined Trm7-Trm734 …
In yeast, Cm(32) is formed by an enzyme that consists of the methyltransferase Trm7 in complex with the auxiliary protein Trm732, and …
Defects in tRNA Anticodon Loop 2'-O-Methylation Are Implicated in Nonsyndromic X-Linked Intellectual Disability due to Mutations in FTSJ1.
Guy MP, Shaw M, Weiner CL, Hobson L, Stark Z, Rose K, Kalscheuer VM, Gecz J, Phizicky EM. Guy MP, et al. Hum Mutat. 2015 Dec;36(12):1176-87. doi: 10.1002/humu.22897. Epub 2015 Sep 10. Hum Mutat. 2015. PMID: 26310293 Free PMC article.
Yeast trm7delta mutants grow poorly due to lack of 2'-O-methylated C32 (Cm32 ) and Gm34 on tRNA(Phe) , catalyzed by Trm7-Trm732 and Trm7-Trm734, respectively, which in turn results in loss of wybutosine at G37 . ...These results also underscore the widespread conser …
Yeast trm7delta mutants grow poorly due to lack of 2'-O-methylated C32 (Cm32 ) and Gm34 on tRNA(Phe) , catalyzed by Trm7-Trm732 and …
Ribo-DT: An automated pipeline for inferring codon dwell times from ribosome profiling data.
Gobet C, Naef F. Gobet C, et al. Methods. 2022 Jul;203:10-16. doi: 10.1016/j.ymeth.2021.10.004. Epub 2021 Oct 18. Methods. 2022. PMID: 34673173 Free article.
We uncovered the effects of those modifications on translation elongation and codon selection during decoding. In particular, knocking out mod5 and trm7 increases codon-specific dwell times which indicates their potential tRNA targets, and highlights effects of nucleotide …
We uncovered the effects of those modifications on translation elongation and codon selection during decoding. In particular, knocking out m …
2'-O-ribose methylation of transfer RNA promotes recovery from oxidative stress in Saccharomyces cerevisiae.
Endres L, Rose RE, Doyle F, Rahn T, Lee B, Seaman J, McIntyre WD, Fabris D. Endres L, et al. PLoS One. 2020 Feb 13;15(2):e0229103. doi: 10.1371/journal.pone.0229103. eCollection 2020. PLoS One. 2020. PMID: 32053677 Free PMC article.
Based on the pronounced oxidative stress sensitivity observed for trm7 mutants, we used a bioinformatic tool to identify transcripts as candidates for regulation by Trm7-catalyzed modifications (i.e., enriched in UUC codons decoded by tRNAPheGmAA). ...
Based on the pronounced oxidative stress sensitivity observed for trm7 mutants, we used a bioinformatic tool to identify transcripts …
Characterization of two homologous 2'-O-methyltransferases showing different specificities for their tRNA substrates.
Somme J, Van Laer B, Roovers M, Steyaert J, Versées W, Droogmans L. Somme J, et al. RNA. 2014 Aug;20(8):1257-71. doi: 10.1261/rna.044503.114. Epub 2014 Jun 20. RNA. 2014. PMID: 24951554 Free PMC article.
Unrelated enzymes catalyzing this modification in Bacteria (TrmJ) and Eukarya (Trm7) have already been identified, but until now, no information is available for the archaeal enzyme. ...
Unrelated enzymes catalyzing this modification in Bacteria (TrmJ) and Eukarya (Trm7) have already been identified, but until now, no …
22 results