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TRMT61B rs4563180 G>C variant reduces hepatoblastoma risk: a case-control study of seven medical centers.
Zeng D, Zhu J, Li J, Liao F, Yang Z, Li Y, Zhang J, Cheng J, Li S, Li L, He J. Zeng D, et al. Aging (Albany NY). 2023 Aug 1;15(15):7583-7592. doi: 10.18632/aging.204926. Epub 2023 Aug 1. Aging (Albany NY). 2023. PMID: 37531210 Free PMC article.
Whether aberrant RNA m(1)A modification is involved in hepatoblast carcinogenesis has not been reported. tRNA methyltransferase 61B (TRMT61B) is responsible for mitochondrial RNA m(1)A modification. Some evidence has shown that genetic variants of TRMT61B might cont …
Whether aberrant RNA m(1)A modification is involved in hepatoblast carcinogenesis has not been reported. tRNA methyltransferase 61B (TRMT …
Mitochondrial RNA methyltransferase TRMT61B is a new, potential biomarker and therapeutic target for highly aneuploid cancers.
Martín A, Epifano C, Vilaplana-Marti B, Hernández I, Macías RIR, Martínez-Ramírez Á, Cerezo A, Cabezas-Sainz P, Garranzo-Asensio M, Amarilla-Quintana S, Gómez-Domínguez D, Caleiras E, Camps J, Gómez-López G, Gómez de Cedrón M, Ramírez de Molina A, Barderas R, Sánchez L, Velasco-Miguel S, Pérez de Castro I. Martín A, et al. Cell Death Differ. 2023 Jan;30(1):37-53. doi: 10.1038/s41418-022-01044-6. Epub 2022 Jul 22. Cell Death Differ. 2023. PMID: 35869285 Free PMC article.
Accordingly, TRMT61B protein levels are increased in tumor cell lines with an imbalanced karyotype as well as in different tumor types when compared to control tissues. Interestingly, while TRMT61B depletion induces senescence in melanoma cell lines with low levels …
Accordingly, TRMT61B protein levels are increased in tumor cell lines with an imbalanced karyotype as well as in different tumor type …
Association between TRMT61B gene polymorphism and Wilms tumor susceptibility in Chinese children.
Huang X, Lu J, Deng C, Tang W, Wang X, Zhou H, Zhang J, Cheng J, Li S, He J, Ruan J. Huang X, et al. BMC Cancer. 2025 Feb 14;25(1):260. doi: 10.1186/s12885-025-13670-7. BMC Cancer. 2025. PMID: 39953499 Free PMC article.
The GTEx database was used to analyze the influence of TRMT61B rs4563180 G > C polymorphism on mRNA expression. RESULTS: The TRMT61B gene polymorphism significantly reduced the susceptibility to Wilms tumor (GC vs. ...CONCLUSIONS: Our results confirm that TRMT …
The GTEx database was used to analyze the influence of TRMT61B rs4563180 G > C polymorphism on mRNA expression. RESULTS: The TR …
Research progress of N1-methyladenosine RNA modification in cancer.
Liu Y, Zhang S, Gao X, Ru Y, Gu X, Hu X. Liu Y, et al. Cell Commun Signal. 2024 Jan 30;22(1):79. doi: 10.1186/s12964-023-01401-z. Cell Commun Signal. 2024. PMID: 38291517 Free PMC article. Review.
Furthermore, this review delves into the key players in m1A modification, known as the "writers," "erasers," and "readers." m1A modification is modified by the m1A methyltransferases, or writers, such as TRMT6, TRMT61A, TRMT61B, TRMT10C, NML, and, removed by the demethylas …
Furthermore, this review delves into the key players in m1A modification, known as the "writers," "erasers," and "readers." m1A modification …
Investigation of TRMT61B methyltransferase activity on mRNA and its effects on translation.
Fang D, Babich JM, Stanton R, Vock IW, Abdallah K, Zhu M, Li R, Simon MD, Gilbert WV, Nachtergaele S. Fang D, et al. bioRxiv [Preprint]. 2025 Dec 8:2025.12.08.692954. doi: 10.64898/2025.12.08.692954. bioRxiv. 2025. Update in: Nucleic Acids Res. 2026 Apr 23;54(8):gkag365. doi: 10.1093/nar/gkag365. PMID: 41427360 Free PMC article. Updated. Preprint.
In these experiments, TRMT61B methylated thousands of novel human mRNA sites, revealing activity on cytosolic mRNAs. ...Taken together, our results can inform future studies of TRMT61B and mRNA, and emphasize that studies of m(1)A regulation of mRNA must be carried …
In these experiments, TRMT61B methylated thousands of novel human mRNA sites, revealing activity on cytosolic mRNAs. ...Taken togethe …
Trmt61B is a methyltransferase responsible for 1-methyladenosine at position 58 of human mitochondrial tRNAs.
Chujo T, Suzuki T. Chujo T, et al. RNA. 2012 Dec;18(12):2269-76. doi: 10.1261/rna.035600.112. Epub 2012 Oct 24. RNA. 2012. PMID: 23097428 Free PMC article.
Trmt61B is dominantly localized to the mitochondria. m1A58 formation in human mitochondrial tRNA(Leu(UUR)) could be reconstituted in vitro using recombinant Trmt61B in the presence of Ado-Met as a methyl donor. ...The bacterial origin of Trmt61B is supported …
Trmt61B is dominantly localized to the mitochondria. m1A58 formation in human mitochondrial tRNA(Leu(UUR)) could be reconstituted in …
Bioinformatics identification and validation of m6A/m1A/m5C/m7G/ac4 C-modified genes in oral squamous cell carcinoma.
Lu CH, Yin XL, Huang ZD, Lv SA, Wu J, Wei J. Lu CH, et al. BMC Cancer. 2025 Jul 1;25(1):1055. doi: 10.1186/s12885-025-14216-7. BMC Cancer. 2025. PMID: 40597017 Free PMC article.
RESULTS: Among the 49 RRGs, four genes (IGF2BP2, HNRNPC, NAT10, and TRMT61B) were found to be associated with the development of OSCC. Based on various methodological validations, a risk score model was constructed using these four genes. ...
RESULTS: Among the 49 RRGs, four genes (IGF2BP2, HNRNPC, NAT10, and TRMT61B) were found to be associated with the development of OSCC …
Investigation of TRMT61B methyltransferase activity on mRNA and its effects on translation.
Fang D, Babich JM, Stanton R, Vock IW, Abdallah K, Zhu M, Letchuman R, Li R, Simon MD, Gilbert WV, Nachtergaele S. Fang D, et al. Nucleic Acids Res. 2026 Apr 23;54(8):gkag365. doi: 10.1093/nar/gkag365. Nucleic Acids Res. 2026. PMID: 42059200 Free PMC article.
In these experiments, TRMT61B methylated thousands of novel human mRNA sites, revealing activity on cytosolic mRNAs. ...Taken together, our results inform future studies of TRMT61B and mRNA modifications, and emphasize that studies of m1A regulation of mRNA must be …
In these experiments, TRMT61B methylated thousands of novel human mRNA sites, revealing activity on cytosolic mRNAs. ...Taken togethe …
Mitochondrial 16S rRNA Is Methylated by tRNA Methyltransferase TRMT61B in All Vertebrates.
Bar-Yaacov D, Frumkin I, Yashiro Y, Chujo T, Ishigami Y, Chemla Y, Blumberg A, Schlesinger O, Bieri P, Greber B, Ban N, Zarivach R, Alfonta L, Pilpel Y, Suzuki T, Mishmar D. Bar-Yaacov D, et al. PLoS Biol. 2016 Sep 15;14(9):e1002557. doi: 10.1371/journal.pbio.1002557. eCollection 2016 Sep. PLoS Biol. 2016. PMID: 27631568 Free PMC article.
Here, we show that these 16S rRNA RDDs result from a 1-methyladenosine (m1A) modification introduced by TRMT61B, thus being the first vertebrate methyltransferase that modifies both tRNA and rRNAs. m1A947 is conserved in humans and all vertebrates having adenine at the cor …
Here, we show that these 16S rRNA RDDs result from a 1-methyladenosine (m1A) modification introduced by TRMT61B, thus being the first …
24 results