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Association of High-Sensitivity Cardiac Troponin I Concentration With Cardiac Outcomes in Patients With Suspected Acute Coronary Syndrome.
Chapman AR, Lee KK, McAllister DA, Cullen L, Greenslade JH, Parsonage W, Worster A, Kavsak PA, Blankenberg S, Neumann J, Sörensen NA, Westermann D, Buijs MM, Verdel GJE, Pickering JW, Than MP, Twerenbold R, Badertscher P, Sabti Z, Mueller C, Anand A, Adamson P, Strachan FE, Ferry A, Sandeman D, Gray A, Body R, Keevil B, Carlton E, Greaves K, Korley FK, Metkus TS, Sandoval Y, Apple FS, Newby DE, Shah ASV, Mills NL. Chapman AR, et al. JAMA. 2017 Nov 21;318(19):1913-1924. doi: 10.1001/jama.2017.17488. JAMA. 2017. PMID: 29127948 Free PMC article. Review.
IMPORTANCE: High-sensitivity cardiac troponin I testing is widely used to evaluate patients with suspected acute coronary syndrome. ...Performance was evaluated in subgroups and across a range of troponin concentrations (2-16 ng/L) using individual patient data. ...
IMPORTANCE: High-sensitivity cardiac troponin I testing is widely used to evaluate patients with suspected acute coronary syndrome. . …
Anti-Cardiac Troponin Autoantibodies Are Specific to the Conformational Epitopes Formed by Cardiac Troponin I and Troponin T in the Ternary Troponin Complex.
Vylegzhanina AV, Kogan AE, Katrukha IA, Antipova OV, Kara AN, Bereznikova AV, Koshkina EV, Katrukha AG. Vylegzhanina AV, et al. Clin Chem. 2017 Jan;63(1):343-350. doi: 10.1373/clinchem.2016.261602. Epub 2016 Nov 4. Clin Chem. 2017. PMID: 27815308
METHODS: The specificity of TnAAbs was studied in immunoassays and gel-filtration experiments. The influence of TnAAbs on endogenous troponin measurements was studied in 35 plasma samples from 15 patients with AMI. RESULTS: The inhibitory effect of TnAAbs on the cTnI immun …
METHODS: The specificity of TnAAbs was studied in immunoassays and gel-filtration experiments. The influence of TnAAbs on endogenous trop
Troponin I is released in bloodstream of patients with acute myocardial infarction not in free form but as complex.
Katrukha AG, Bereznikova AV, Esakova TV, Pettersson K, Lövgren T, Severina ME, Pulkki K, Vuopio-Pulkki LM, Gusev NB. Katrukha AG, et al. Clin Chem. 1997 Aug;43(8 Pt 1):1379-85. Clin Chem. 1997. PMID: 9267317
Fourteen monoclonal antibodies (mAbs) against human cardiac troponin I (cTnI) were generated by commonly used experimental techniques. All these antibodies, as well as antibody 414 (HyTest), were specific for human cTnI. Fifteen antibodies thus obtained were tested …
Fourteen monoclonal antibodies (mAbs) against human cardiac troponin I (cTnI) were generated by commonly used experimental techniques …
Biochemical factors influencing measurement of cardiac troponin I in serum.
Katrukha A, Bereznikova A, Filatov V, Esakova T. Katrukha A, et al. Clin Chem Lab Med. 1999 Nov-Dec;37(11-12):1091-5. doi: 10.1515/CCLM.1999.159. Clin Chem Lab Med. 1999. PMID: 10726817 Review.
Troponin I (cTnI), a sensitive and reliable marker of damaged cardiac tissue, is now widely used in clinics. ...
Troponin I (cTnI), a sensitive and reliable marker of damaged cardiac tissue, is now widely used in clinics. ...
Full-Size Cardiac Troponin I and Its Proteolytic Fragments in Blood of Patients with Acute Myocardial Infarction: Antibody Selection for Assay Development.
Katrukha IA, Kogan AE, Vylegzhanina AV, Kharitonov AV, Tamm NN, Filatov VL, Bereznikova AV, Koshkina EV, Katrukha AG. Katrukha IA, et al. Clin Chem. 2018 Jul;64(7):1104-1112. doi: 10.1373/clinchem.2017.286211. Epub 2018 Apr 9. Clin Chem. 2018. PMID: 29632125
BACKGROUND: In the blood of patients with acute myocardial infarction (AMI), cardiac troponin I (cTnI) presents as an intact molecule with a repertoire of proteolytic fragments. ...
BACKGROUND: In the blood of patients with acute myocardial infarction (AMI), cardiac troponin I (cTnI) presents as an intact molecule …
Full-Size and Partially Truncated Cardiac Troponin Complexes in the Blood of Patients with Acute Myocardial Infarction.
Vylegzhanina AV, Kogan AE, Katrukha IA, Koshkina EV, Bereznikova AV, Filatov VL, Bloshchitsyna MN, Bogomolova AP, Katrukha AG. Vylegzhanina AV, et al. Clin Chem. 2019 Jul;65(7):882-892. doi: 10.1373/clinchem.2018.301127. Epub 2019 Mar 11. Clin Chem. 2019. PMID: 30858159
BACKGROUND: The measurement of cardiac isoforms of troponin I (cTnI) and troponin T (cTnT) is widely used for the diagnosis of acute myocardial infarction (AMI). ...Only 16- to 27-kDa central fragments of cTnT were present in a free form in patient blood. CONCLUSION …
BACKGROUND: The measurement of cardiac isoforms of troponin I (cTnI) and troponin T (cTnT) is widely used for the diagnosis of …
CT-IGFBP-4 as a novel prognostic biomarker in acute heart failure.
Konev AA, Kharitonov AV, Rozov FN, Altshuler EP, Serebryanaya DV, Lassus J, Harjola VP, Katrukha AG, Postnikov AB. Konev AA, et al. ESC Heart Fail. 2020 Apr;7(2):434-444. doi: 10.1002/ehf2.12590. Epub 2020 Jan 22. ESC Heart Fail. 2020. PMID: 31967738 Free PMC article.
Cox hazard analysis indicated that elevated CT-IGFBP-4 was independently associated with 1 year mortality (hazard ratio 3.26, P = 0.0008) after adjustment for age, gender, history of previous heart failure, coronary artery disease, hypertension, chronic kidney failure, history of …
Cox hazard analysis indicated that elevated CT-IGFBP-4 was independently associated with 1 year mortality (hazard ratio 3.26, P = 0.0008) af …
Degradation of cardiac troponin I: implication for reliable immunodetection.
Katrukha AG, Bereznikova AV, Filatov VL, Esakova TV, Kolosova OV, Pettersson K, Lövgren T, Bulargina TV, Trifonov IR, Gratsiansky NA, Pulkki K, Voipio-Pulkki LM, Gusev NB. Katrukha AG, et al. Clin Chem. 1998 Dec;44(12):2433-40. Clin Chem. 1998. PMID: 9836709
We have analyzed by different immunological methods the proteolytic degradation of cardiac troponin I (cTnI) in human necrotic tissue and in serum. cTnI is susceptible to proteolysis, and its degradation leads to the appearance of a wide diversity of proteolytic peptides w …
We have analyzed by different immunological methods the proteolytic degradation of cardiac troponin I (cTnI) in human necrotic tissue …
Myocardial Injury and the Release of Troponins I and T in the Blood of Patients.
Katrukha IA, Katrukha AG. Katrukha IA, et al. Clin Chem. 2021 Jan 8;67(1):124-130. doi: 10.1093/clinchem/hvaa281. Clin Chem. 2021. PMID: 33418589 Review.
BACKGROUND: Cardiac troponin I (cTnI) and cTnT are the established biomarkers of cardiomyocyte damage and the recommended biomarkers for the diagnosis of acute myocardial infarction (MI). ...SUMMARY: Different etiologies of disease associated with increases of cTn above th …
BACKGROUND: Cardiac troponin I (cTnI) and cTnT are the established biomarkers of cardiomyocyte damage and the recommended biomarkers …
17 results