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Page 1
Hereditary Alpha Tryptasemia: Genotyping and Associated Clinical Features.
Lyons JJ. Lyons JJ. Immunol Allergy Clin North Am. 2018 Aug;38(3):483-495. doi: 10.1016/j.iac.2018.04.003. Epub 2018 Jun 9. Immunol Allergy Clin North Am. 2018. PMID: 30007465 Free PMC article. Review.
Hereditary alpha tryptasemia is an autosomal dominant genetic trait caused by increased germline copies of TPSAB1 encoding alpha-tryptase. Individuals with this trait have elevated basal serum tryptase, and may present with associated mul …
Hereditary alpha tryptasemia is an autosomal dominant genetic trait caused by increased germline copies of TPSAB1 encod …
Hereditary alpha tryptasemia: elevated tryptase, female sex, thyroid disorders, and anaphylaxis.
Puxkandl V, Aigner S, Hoetzenecker W, Altrichter S. Puxkandl V, et al. Front Allergy. 2024 Nov 12;5:1461359. doi: 10.3389/falgy.2024.1461359. eCollection 2024. Front Allergy. 2024. PMID: 39600380 Free PMC article.
Recently, a genetic variation of the TPSAB1 gene, which among others encodes for alpha tryptase, has been reported and named hereditary alpha tryptasemia (HaT). ...A control group included patients with a history of anaphylaxis undergoing specif …
Recently, a genetic variation of the TPSAB1 gene, which among others encodes for alpha tryptase, has been reported and …
Genetic Regulation of Tryptase Production and Clinical Impact: Hereditary Alpha Tryptasemia, Mastocytosis and Beyond.
Sprinzl B, Greiner G, Uyanik G, Arock M, Haferlach T, Sperr WR, Valent P, Hoermann G. Sprinzl B, et al. Int J Mol Sci. 2021 Feb 28;22(5):2458. doi: 10.3390/ijms22052458. Int J Mol Sci. 2021. PMID: 33671092 Free PMC article. Review.
MC activation, degranulation and mediator release contribute to various immunological processes, but also to several specific diseases, such as IgE-dependent allergies and clonal MC disorders. Biologically active tryptase tetramers primarily derive from the two genes TPSB2 …
MC activation, degranulation and mediator release contribute to various immunological processes, but also to several specific diseases, such …
Hereditary alpha tryptasemia and clinical implications.
Tüsüz Önata E, Özdemir Ö, Savaşan S. Tüsüz Önata E, et al. World J Clin Cases. 2025 Jul 26;13(21):104723. doi: 10.12998/wjcc.v13.i21.104723. World J Clin Cases. 2025. PMID: 40726930 Free PMC article. Review.
Hereditary alpha tryptasemia was first described in 2016 and is the most common (up to 72%) cause of elevated serum basal tryptase (TPS). ...This review provided an overview of hereditary alpha tryptasemia and increased awareness of this conditi …
Hereditary alpha tryptasemia was first described in 2016 and is the most common (up to 72%) cause of elevated serum basal t …
Heritable risk for severe anaphylaxis associated with increased alpha-tryptase-encoding germline copy number at TPSAB1.
Lyons JJ, Chovanec J, O'Connell MP, Liu Y, Šelb J, Zanotti R, Bai Y, Kim J, Le QT, DiMaggio T, Schwartz LB, Komarow HD, Rijavec M, Carter MC, Milner JD, Bonadonna P, Metcalfe DD, Korošec P. Lyons JJ, et al. J Allergy Clin Immunol. 2021 Feb;147(2):622-632. doi: 10.1016/j.jaci.2020.06.035. Epub 2020 Jul 24. J Allergy Clin Immunol. 2021. PMID: 32717252
RESULTS: Hereditary alpha-tryptasemia (HalphaT)-a genetic trait caused by increased alpha-tryptase-encoding Tryptase-alpha/beta1 (TPSAB1) copy number resulting in elevated BST level-was common in healthy individuals (5.6% [n = 7 of …
RESULTS: Hereditary alpha-tryptasemia (HalphaT)-a genetic trait caused by increased alpha-tryptase-encoding T …
Hereditary alpha-tryptasemia; a review of mechanisms linking alpha-tryptase gene dosage to intestinal homeostasis and immunopathology.
Simeone IM, Galeas-Pena M, White K, Sullivan B, Morelli A, Silvester JA, Konnikova L, Therrien A, Glover SC. Simeone IM, et al. Front Allergy. 2026 Apr 14;7:1783914. doi: 10.3389/falgy.2026.1783914. eCollection 2026. Front Allergy. 2026. PMID: 42058624 Free PMC article. Review.
Hereditary alpha-tryptasemia (HalphaT) is a genetic trait characterized by increased TPSAB1 copy number. ...HalphaT represents a natural human model of alpha-tryptase overexpression which can be leveraged to better and more comprehensively under …
Hereditary alpha-tryptasemia (HalphaT) is a genetic trait characterized by increased TPSAB1 copy number. ...HalphaT rep …
Hereditary Alpha-Tryptasemia and Mastocytosis: What We Know and What We Need To Learn.
Rama TA, Gulen T. Rama TA, et al. Curr Allergy Asthma Rep. 2026 Mar 9;26(1):19. doi: 10.1007/s11882-026-01262-9. Curr Allergy Asthma Rep. 2026. PMID: 41801525 Free PMC article. Review.
RECENT FINDINGS: HalphaT is a common genetic trait caused by increased copy numbers of the TPSAB1 gene encoding alpha-tryptase. It accounts for most elevated serum baseline tryptase (SBT) levels (> 8 ng/mL) seen in clinical allergy practice. Diagnos …
RECENT FINDINGS: HalphaT is a common genetic trait caused by increased copy numbers of the TPSAB1 gene encoding alpha-trypt …
Hereditary alpha tryptasemia and food allergy.
Lang A. Lang A. Front Allergy. 2025 May 20;6:1583462. doi: 10.3389/falgy.2025.1583462. eCollection 2025. Front Allergy. 2025. PMID: 40463362 Free PMC article. Review.
Food allergy (FA) and hereditary alpha-tryptasemia (HalphaT) are both relatively common conditions, but potential associations between these diagnoses have not been well-studied. ...This mini review summarizes the epidemiology and diagnostic considerations of FA for …
Food allergy (FA) and hereditary alpha-tryptasemia (HalphaT) are both relatively common conditions, but potential associations …
Impact of naturally forming human alpha/beta-tryptase heterotetramers in the pathogenesis of hereditary alpha-tryptasemia.
Le QT, Lyons JJ, Naranjo AN, Olivera A, Lazarus RA, Metcalfe DD, Milner JD, Schwartz LB. Le QT, et al. J Exp Med. 2019 Oct 7;216(10):2348-2361. doi: 10.1084/jem.20190701. Epub 2019 Jul 23. J Exp Med. 2019. PMID: 31337736 Free PMC article.
Both alpha-tryptase and beta-tryptase are preferentially expressed by human mast cells, but the purpose of alpha-tryptase is enigmatic, because its tetramers lack protease activity, whereas beta-tryptase tetramers are active proteases. .. …
Both alpha-tryptase and beta-tryptase are preferentially expressed by human mast cells, but the purpose of alpha …
57 results