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2003 55
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2,948 results

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Page 1
Indoleamine 2,3-dioxygenase (IDO) inhibitors and cancer immunotherapy.
Fujiwara Y, Kato S, Nesline MK, Conroy JM, DePietro P, Pabla S, Kurzrock R. Fujiwara Y, et al. Cancer Treat Rev. 2022 Nov;110:102461. doi: 10.1016/j.ctrv.2022.102461. Epub 2022 Aug 30. Cancer Treat Rev. 2022. PMID: 36058143 Free PMC article. Review.
Strategies for unlocking immunosuppression in the tumor microenvironment have been investigated to overcome resistance to first-generation immune checkpoint blockade with anti- programmed cell death protein 1 (PD-1)/ programmed death-ligand 1 (PD-L1) and anti-cytotoxic T-lymphocy …
Strategies for unlocking immunosuppression in the tumor microenvironment have been investigated to overcome resistance to first-generation i …
Tryptophan 2,3-dioxygenase-positive matrix fibroblasts fuel breast cancer lung metastasis via kynurenine-mediated ferroptosis resistance of metastatic cells and T cell dysfunction.
Liu Y, Chen S, Wan X, Wang R, Luo H, Chang C, Dai P, Gan Y, Guo Y, Hou Y, Sun Y, Teng Y, Cui X, Liu M. Liu Y, et al. Cancer Commun (Lond). 2024 Nov;44(11):1261-1286. doi: 10.1002/cac2.12608. Epub 2024 Sep 2. Cancer Commun (Lond). 2024. PMID: 39221971 Free PMC article.
Transgenic mice were used to examine the contribution of tryptophan 2,3-dioxygenase-positive matrix fibroblasts (TDO2(+) MFs) in lung metastasis. ...Conditional knockout of Tdo2 in MFs diminished lung metastasis and enhanced immune activation. C …
Transgenic mice were used to examine the contribution of tryptophan 2,3-dioxygenase-positive matrix fibroblasts …
Molecular mechanisms and therapeutic significance of Tryptophan Metabolism and signaling in cancer.
Yan J, Chen D, Ye Z, Zhu X, Li X, Jiao H, Duan M, Zhang C, Cheng J, Xu L, Li H, Yan D. Yan J, et al. Mol Cancer. 2024 Oct 30;23(1):241. doi: 10.1186/s12943-024-02164-y. Mol Cancer. 2024. PMID: 39472902 Free PMC article. Review.
Tryptophan (Trp) metabolism involves three primary pathways: the kynurenine (Kyn) pathway (KP), the 5-hydroxytryptamine (serotonin, 5-HT) pathway, and the indole pathway. ...Key rate-limiting enzymes such as indoleamine-2,3-dioxygenase (IDO), Trp-2 …
Tryptophan (Trp) metabolism involves three primary pathways: the kynurenine (Kyn) pathway (KP), the 5-hydroxytryptamine (serotonin, 5 …
Tryptophan 2,3-dioxygenase, a novel therapeutic target for Parkinson's disease.
Boros FA, Vécsei L. Boros FA, et al. Expert Opin Ther Targets. 2021 Oct;25(10):877-888. doi: 10.1080/14728222.2021.1999928. Epub 2021 Nov 26. Expert Opin Ther Targets. 2021. PMID: 34720020
INTRODUCTION: Alterations in the activity of tryptophan 2,3-dioxygenase (TDO) cause imbalances in the levels of serotonin and other neuroactive metabolites which can contribute to motor, psychiatric, gastrointestinal, and other dysfunctions ofte …
INTRODUCTION: Alterations in the activity of tryptophan 2,3-dioxygenase (TDO) cause imbalances in the lev …
Current state on tryptophan 2,3-dioxygenase inhibitors: a patent review.
Kozlova A, Frédérick R. Kozlova A, et al. Expert Opin Ther Pat. 2019 Jan;29(1):11-23. doi: 10.1080/13543776.2019.1556638. Epub 2019 Jan 16. Expert Opin Ther Pat. 2019. PMID: 30526149 Review.
INTRODUCTION: Tryptophan-2, 3-dioxygenase (TDO2) is a tryptophan-degrading enzyme constitutively expressed in the liver and to a lesser extend in the brain. ...AREAS COVERED: Patent literature regarding Tryptophan-2, 3-di …
INTRODUCTION: Tryptophan-2, 3-dioxygenase (TDO2) is a tryptophan-degrading enzyme constitutively expresse …
Inhibitory effect of ascorbate on tryptophan 2,3-dioxygenase.
Yuasa HJ. Yuasa HJ. J Biochem. 2022 May 27;171(6):653-661. doi: 10.1093/jb/mvac024. J Biochem. 2022. PMID: 35244712
Tryptophan 2,3-dioxygenase (TDO) and indoleamine 2,3-dioxygenase (IDO) catalyse the same reaction, oxidative cleavage of L-tryptophan (L-Trp) to N-formyl-kynurenine. ...Interestingly, however, no inhibitory effect of Asc was …
Tryptophan 2,3-dioxygenase (TDO) and indoleamine 2,3-dioxygenase (IDO) catalyse the same re …
Increased Tryptophan Metabolism Is Associated With Activity of Inflammatory Bowel Diseases.
Nikolaus S, Schulte B, Al-Massad N, Thieme F, Schulte DM, Bethge J, Rehman A, Tran F, Aden K, Häsler R, Moll N, Schütze G, Schwarz MJ, Waetzig GH, Rosenstiel P, Krawczak M, Szymczak S, Schreiber S. Nikolaus S, et al. Gastroenterology. 2017 Dec;153(6):1504-1516.e2. doi: 10.1053/j.gastro.2017.08.028. Epub 2017 Aug 19. Gastroenterology. 2017. PMID: 28827067 Free article.
We found a negative correlation between serum levels of tryptophan and disease activity or levels of C-reactive protein. Levels of messenger RNAs encoding tryptophan 2,3-dioxygenase-2 and solute carrier family 6 member 19 (also called B0A …
We found a negative correlation between serum levels of tryptophan and disease activity or levels of C-reactive protein. Level …
Targeting the IDO1/TDO2-KYN-AhR Pathway for Cancer Immunotherapy - Challenges and Opportunities.
Cheong JE, Sun L. Cheong JE, et al. Trends Pharmacol Sci. 2018 Mar;39(3):307-325. doi: 10.1016/j.tips.2017.11.007. Epub 2017 Dec 15. Trends Pharmacol Sci. 2018. PMID: 29254698 Review.
Indoleamine 2,3-dioxygenase 1 (IDO1) and tryptophan 2,3-dioxygenase 2 (TDO2) catalyze the commitment step of the kynurenine (KYN) metabolic pathway. Traditionally the immunosuppressive effect of IDO1 has been attributed mainly to r …
Indoleamine 2,3-dioxygenase 1 (IDO1) and tryptophan 2,3-dioxygenase 2 (TDO2) catalyze the c …
Modeling Tryptophan/Indoleamine 2,3-Dioxygenase with Heme Superoxide Mimics: Is Ferryl the Key Intermediate?
Mondal P, Wijeratne GB. Mondal P, et al. J Am Chem Soc. 2020 Jan 29;142(4):1846-1856. doi: 10.1021/jacs.9b10498. Epub 2020 Jan 13. J Am Chem Soc. 2020. PMID: 31870154
This 2,3-dioxygenative cleavage of the indole ring of tryptophan with dioxygen is mediated by two heme enzymes, tryptophan 2,3-dioxygenase (TDO) and indoleamine 2,3-dioxygenase (IDO), during its conversion to N …
This 2,3-dioxygenative cleavage of the indole ring of tryptophan with dioxygen is mediated by two heme enzymes, tryp …
Tryptophan 2,3-dioxygenase: a review of the roles of the heme and copper cofactors in catalysis.
Brady FO. Brady FO. Bioinorg Chem. 1975;5(2):167-82. doi: 10.1016/s0006-3061(00)80058-7. Bioinorg Chem. 1975. PMID: 178384 Review.
L-Tryptophan, 2,3-dioxygenase (EC 1.13.11.11) has been purified to homogenity from L-tryptophan induced Pseudomonas acidovorans (ATCC 11299b) and from L-tryptophan and cortisone induced rat liver. ...The proteins from the two sources are …
L-Tryptophan, 2,3-dioxygenase (EC 1.13.11.11) has been purified to homogenity from L-tryptophan induced P …
2,948 results