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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1971 1
1974 3
1975 3
1976 2
1977 3
1978 2
1980 1
1981 4
1982 1
1983 1
1984 2
1985 2
1986 2
1988 2
1989 2
1991 3
1993 1
1996 1
1999 1
2000 2
2001 1
2002 1
2003 5
2004 3
2006 3
2007 1
2008 1
2009 4
2010 2
2012 2
2013 2
2014 3
2015 1
2016 1
2018 5
2019 6
2020 4
2021 7
2022 7
2023 11
2024 4
2025 6
2026 7

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117 results

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Page 1
Integrated metagenomic and metabolomic analysis reveals distinct gut-microbiome-derived phenotypes in early-onset colorectal cancer.
Kong C, Liang L, Liu G, Du L, Yang Y, Liu J, Shi D, Li X, Ma Y. Kong C, et al. Gut. 2023 Jun;72(6):1129-1142. doi: 10.1136/gutjnl-2022-327156. Epub 2022 Aug 11. Gut. 2023. PMID: 35953094
Fusobacterium nucleatum enrichment and short-chain fatty acid depletion, including reduced microbial GABA biosynthesis and a shift in acetate/acetaldehyde metabolism towards acetyl-CoA production characterises LO-CRC. In comparison, multiomics signatures of E …
Fusobacterium nucleatum enrichment and short-chain fatty acid depletion, including reduced microbial GABA biosynthesis and a shift in acetat …
Effects on the diet on brain neurotransmitters.
Fernstrom JD. Fernstrom JD. Metabolism. 1977 Feb;26(2):207-23. doi: 10.1016/0026-0495(77)90057-9. Metabolism. 1977. PMID: 13261 Review.
Serotonin synthesis depends largely on the brain concentrations of L-tryptophan, its precursor amino aicd. This relationship appears to be physiologic: when brain tryptophan levels vary because of insulin secretion or meal ingestion, corresponding alterations occur …
Serotonin synthesis depends largely on the brain concentrations of L-tryptophan, its precursor amino aicd. This relationship appears …
Metabolic Signature of Arsenic Exposure and Metabolism: The Folic Acid and Creatine Trial.
Li W, Wu H, Goldsmith J, Glabonjat RA, Ilievski V, Balac O, Slavkovich V, Pinto-Pacheco B, Lin X, Parvez F, Jackson GL, Siddique AB, Uddin MN, Islam T, Martinez-Morata I, Navas-Acien A, Niedzwiecki MM, Kioumourtzoglou MA, Pierce BL, Graziano JH, Bottiglieri T, Walker DI, Gamble MV. Li W, et al. Environ Sci Technol. 2025 Jul 29;59(29):14905-14916. doi: 10.1021/acs.est.5c01597. Epub 2025 Jul 16. Environ Sci Technol. 2025. PMID: 40668877 Free PMC article. Clinical Trial.
Folic acid (FA) supplementation enhances one-carbon metabolism (OCM), thus promoting arsenic methylation and facilitating urinary arsenic elimination. ...Metabolic pathways enriched for bAs and %uAs were similar, highlighting phenylalanine, tyrosine, and tryptophan …
Folic acid (FA) supplementation enhances one-carbon metabolism (OCM), thus promoting arsenic methylation and facilitating urinary ars …
Targeting glutaryl-CoA dehydrogenase-driven acetyl coenzyme A acetyltransferase 2 crotonylation dysregulates cholesterol metabolism in pancreatic cancer cells.
Han F, Zhang H, Ye Q, Zhang Q, Shen W, Bian K, Chen F, Guo J, Mu M, Ma J. Han F, et al. Int J Biol Macromol. 2026 Jan;335(Pt 2):149182. doi: 10.1016/j.ijbiomac.2025.149182. Epub 2025 Nov 22. Int J Biol Macromol. 2026. PMID: 41285334
We demonstrated that the upregulation of glutaryl-CoA dehydrogenase (GCDH), a key gene encoding a metabolic enzyme involved in the conversion of lysine and tryptophan to crotonyl-CoA, was correlated with worse prognosis in patients with pancreatic ductal aden …
We demonstrated that the upregulation of glutaryl-CoA dehydrogenase (GCDH), a key gene encoding a metabolic enzyme involved in the co …
Enzymes with molecular tunnels.
Raushel FM, Thoden JB, Holden HM. Raushel FM, et al. Acc Chem Res. 2003 Jul;36(7):539-48. doi: 10.1021/ar020047k. Acc Chem Res. 2003. PMID: 12859215 Review.
Since the first molecular tunnel within tryptophan synthase was discovered in 1988, tunnels within carbamoyl phosphate synthetase, glutamine phosphoribosylpyrophosphate amidotransferase, asparagine synthetase, glutamate synthase, imidazole glycerol phosphate synthase, gluc …
Since the first molecular tunnel within tryptophan synthase was discovered in 1988, tunnels within carbamoyl phosphate synthetase, gl …
Biosynthesis of polyene macrolide antibiotics.
Martín JF. Martín JF. Annu Rev Microbiol. 1977;31:13-38. doi: 10.1146/annurev.mi.31.100177.000305. Annu Rev Microbiol. 1977. PMID: 20831 Review. No abstract available.
Multi-OMICs analysis reveals metabolic and epigenetic changes associated with macrophage polarization.
Sowers ML, Tang H, Singh VK, Khan A, Mishra A, Restrepo BI, Jagannath C, Zhang K. Sowers ML, et al. J Biol Chem. 2022 Oct;298(10):102418. doi: 10.1016/j.jbc.2022.102418. Epub 2022 Aug 27. J Biol Chem. 2022. PMID: 36030823 Free PMC article.
We report here a complex relationship between arginine, tryptophan, glucose, and the citric acid cycle metabolism, protein and histone post-translational modifications, and human macrophage polarization that was previously not described. Surprisingly, M1-M s had glo …
We report here a complex relationship between arginine, tryptophan, glucose, and the citric acid cycle metabolism, protein and …
Diabetes and branched-chain amino acids: What is the link?
Bloomgarden Z. Bloomgarden Z. J Diabetes. 2018 May;10(5):350-352. doi: 10.1111/1753-0407.12645. Epub 2018 Feb 13. J Diabetes. 2018. PMID: 29369529
Similarly, higher BCAA levels track with cardiovascular disease. [Figure: see text] The metabolism of BCAA involves two processes: (i) a reversible process catalysed by a branched-chain aminotransferase (BCAT), either cytosolic or mitochondrial, requiring pyridoxal …
Similarly, higher BCAA levels track with cardiovascular disease. [Figure: see text] The metabolism of BCAA involves two processes: (i …
Conformational Selection Governs Carrier Domain Positioning in Staphylococcus aureus Pyruvate Carboxylase.
Hakala JH, Laseke AJ, Koza AL, St Maurice M. Hakala JH, et al. Biochemistry. 2022 Sep 6;61(17):1824-1835. doi: 10.1021/acs.biochem.2c00298. Epub 2022 Aug 9. Biochemistry. 2022. PMID: 35943735 Free PMC article.
Cross-linking was monitored by gel electrophoresis, inactivation kinetics, and intrinsic tryptophan fluorescence. We demonstrate that the carrier domain positioning equilibrium is sensitive to substrate analogues and the allosteric activator acetyl-CoA. ...
Cross-linking was monitored by gel electrophoresis, inactivation kinetics, and intrinsic tryptophan fluorescence. We demonstrate that …
Chemistry and biology of E. coli ribosomal protein L12.
Brot N, Weissbach H. Brot N, et al. Mol Cell Biochem. 1981 Apr 13;36(1):47-63. doi: 10.1007/BF02354831. Mol Cell Biochem. 1981. PMID: 7017380 Review.
A specific enzyme that acetylates L12 to form L7, using acetyl-CoA as the acetyl donor, has been purified from E. coli extracts. L12 is also unique in that it does not contain cysteine, tryptophan, histidine, or tyrosine, is very acidic (pI: 4.85) and …
A specific enzyme that acetylates L12 to form L7, using acetyl-CoA as the acetyl donor, has been purified from E. coli …
117 results