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Serotonin, tryptophan metabolism and the brain-gut-microbiome axis.
O'Mahony SM, Clarke G, Borre YE, Dinan TG, Cryan JF. O'Mahony SM, et al. Behav Brain Res. 2015 Jan 15;277:32-48. doi: 10.1016/j.bbr.2014.07.027. Epub 2014 Jul 29. Behav Brain Res. 2015. PMID: 25078296 Review.
Accumulating evidence points to a critical role for the gut microbiome in regulating normal functioning of this axis. In particular, it is becoming clear that the microbial influence on tryptophan metabolism and the serotonergic system may be an important node in su …
Accumulating evidence points to a critical role for the gut microbiome in regulating normal functioning of this axis. In particular, …
Bifidobacterium breve CCFM1025 attenuates major depression disorder via regulating gut microbiome and tryptophan metabolism: A randomized clinical trial.
Tian P, Chen Y, Zhu H, Wang L, Qian X, Zou R, Zhao J, Zhang H, Qian L, Wang Q, Wang G, Chen W. Tian P, et al. Brain Behav Immun. 2022 Feb;100:233-241. doi: 10.1016/j.bbi.2021.11.023. Epub 2021 Dec 4. Brain Behav Immun. 2022. PMID: 34875345 Clinical Trial.
., cortisol, TNF-alpha, and IL-beta. Serotonin turnover in the circulation, gut microbiome composition, and tryptophan metabolites were further investigated for clarifying the probiotics' mechanisms of action. ...Specifically, CCFM1025 could significantly and to a l …
., cortisol, TNF-alpha, and IL-beta. Serotonin turnover in the circulation, gut microbiome composition, and tryptophan metabol …
Tryptophan Metabolism and Gut-Brain Homeostasis.
Roth W, Zadeh K, Vekariya R, Ge Y, Mohamadzadeh M. Roth W, et al. Int J Mol Sci. 2021 Mar 15;22(6):2973. doi: 10.3390/ijms22062973. Int J Mol Sci. 2021. PMID: 33804088 Free PMC article. Review.
Tryptophan is an essential amino acid critical for protein synthesis in humans that has emerged as a key player in the microbiota-gut-brain axis. ...The gut microbiome has thus garnered much attention as a therapeutic target for both neurologic and psychiatri
Tryptophan is an essential amino acid critical for protein synthesis in humans that has emerged as a key player in the microbiota
Gut Microbiota Regulation of Tryptophan Metabolism in Health and Disease.
Agus A, Planchais J, Sokol H. Agus A, et al. Cell Host Microbe. 2018 Jun 13;23(6):716-724. doi: 10.1016/j.chom.2018.05.003. Cell Host Microbe. 2018. PMID: 29902437 Free article. Review.
The gut microbiota is a crucial actor in human physiology. Many of these effects are mediated by metabolites that are either produced by the microbes or derived from the transformation of environmental or host molecules. Among the array of metabolites at the interface betw …
The gut microbiota is a crucial actor in human physiology. Many of these effects are mediated by metabolites that are either produced …
Host and gut microbial tryptophan metabolism and type 2 diabetes: an integrative analysis of host genetics, diet, gut microbiome and circulating metabolites in cohort studies.
Qi Q, Li J, Yu B, Moon JY, Chai JC, Merino J, Hu J, Ruiz-Canela M, Rebholz C, Wang Z, Usyk M, Chen GC, Porneala BC, Wang W, Nguyen NQ, Feofanova EV, Grove ML, Wang TJ, Gerszten RE, Dupuis J, Salas-Salvadó J, Bao W, Perkins DL, Daviglus ML, Thyagarajan B, Cai J, Wang T, Manson JE, Martínez-González MA, Selvin E, Rexrode KM, Clish CB, Hu FB, Meigs JB, Knight R, Burk RD, Boerwinkle E, Kaplan RC. Qi Q, et al. Gut. 2022 Jun;71(6):1095-1105. doi: 10.1136/gutjnl-2021-324053. Epub 2021 Jun 14. Gut. 2022. PMID: 34127525 Free PMC article.
OBJECTIVE: Tryptophan can be catabolised to various metabolites through host kynurenine and microbial indole pathways. We aimed to examine relationships of host and microbial tryptophan metabolites with incident type 2 diabetes (T2D), host genetics, diet and gut …
OBJECTIVE: Tryptophan can be catabolised to various metabolites through host kynurenine and microbial indole pathways. We aimed to ex …
The Microbiome-Gut-Brain Axis in Health and Disease.
Dinan TG, Cryan JF. Dinan TG, et al. Gastroenterol Clin North Am. 2017 Mar;46(1):77-89. doi: 10.1016/j.gtc.2016.09.007. Epub 2017 Jan 4. Gastroenterol Clin North Am. 2017. PMID: 28164854 Review.
Irritable bowel syndrome is regarded as the prototypic disorder of the brain-gut-microbiota axis that can be responsive to probiotic therapy. Translational studies indicate that certain bacteria may have an impact on stress responses and cognitive functioning. Manipulating …
Irritable bowel syndrome is regarded as the prototypic disorder of the brain-gut-microbiota axis that can be responsive to probiotic …
Tryptophan-derived microbial metabolites activate the aryl hydrocarbon receptor in tumor-associated macrophages to suppress anti-tumor immunity.
Hezaveh K, Shinde RS, Klötgen A, Halaby MJ, Lamorte S, Ciudad MT, Quevedo R, Neufeld L, Liu ZQ, Jin R, Grünwald BT, Foerster EG, Chaharlangi D, Guo M, Makhijani P, Zhang X, Pugh TJ, Pinto DM, Co IL, McGuigan AP, Jang GH, Khokha R, Ohashi PS, O'Kane GM, Gallinger S, Navarre WW, Maughan H, Philpott DJ, Brooks DG, McGaha TL. Hezaveh K, et al. Immunity. 2022 Feb 8;55(2):324-340.e8. doi: 10.1016/j.immuni.2022.01.006. Immunity. 2022. PMID: 35139353
Deletion of Ahr in myeloid cells or pharmacologic inhibition of AhR reduced PDAC growth, improved efficacy of immune checkpoint blockade, and increased intra-tumoral frequencies of IFNgamma(+)CD8(+) T cells. Macrophage tryptophan metabolism was not required for this effect …
Deletion of Ahr in myeloid cells or pharmacologic inhibition of AhR reduced PDAC growth, improved efficacy of immune checkpoint blockade, an …
The role of inflammation and the gut microbiome in depression and anxiety.
Peirce JM, Alviña K. Peirce JM, et al. J Neurosci Res. 2019 Oct;97(10):1223-1241. doi: 10.1002/jnr.24476. Epub 2019 May 29. J Neurosci Res. 2019. PMID: 31144383 Review.
We also document multiple pathways by which stress-induced inflammation harms brain function and ultimately affects mental health, and review how probiotic and prebiotic treatments have shown to be beneficial. Lastly, we provide an overview of gut microbiome-derived compou …
We also document multiple pathways by which stress-induced inflammation harms brain function and ultimately affects mental health, and revie …
Tryptophan Metabolism: A Link Between the Gut Microbiota and Brain.
Gao K, Mu CL, Farzi A, Zhu WY. Gao K, et al. Adv Nutr. 2020 May 1;11(3):709-723. doi: 10.1093/advances/nmz127. Adv Nutr. 2020. PMID: 31825083 Free PMC article. Review.
Here, we focus on the potential role of tryptophan metabolism in the modulation of brain function by the gut microbiota. We start by outlining existing knowledge on tryptophan metabolism, including serotonin synthesis and degradation pathways of the host, and …
Here, we focus on the potential role of tryptophan metabolism in the modulation of brain function by the gut microbiota. We st …
Tryptophan Metabolism as a Pharmacological Target.
Modoux M, Rolhion N, Mani S, Sokol H. Modoux M, et al. Trends Pharmacol Sci. 2021 Jan;42(1):60-73. doi: 10.1016/j.tips.2020.11.006. Epub 2020 Nov 27. Trends Pharmacol Sci. 2021. PMID: 33256987 Free article. Review.
L-Tryptophan is an essential amino acid required for protein synthesis. ...This review will briefly describe L-tryptophan metabolism and present and discuss the most recent pharmacological developments targeting it....
L-Tryptophan is an essential amino acid required for protein synthesis. ...This review will briefly describe L-tryptophan meta …
1,354 results