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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1967 1
1979 1
2004 1
2007 1
2008 1
2009 1
2010 3
2011 4
2012 10
2013 15
2014 24
2015 36
2016 53
2017 76
2018 114
2019 130
2020 148
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Serotonin, tryptophan metabolism and the brain-gut-microbiome axis.
O'Mahony SM, Clarke G, Borre YE, Dinan TG, Cryan JF. O'Mahony SM, et al. Behav Brain Res. 2015 Jan 15;277:32-48. doi: 10.1016/j.bbr.2014.07.027. Epub 2014 Jul 29. Behav Brain Res. 2015. PMID: 25078296 Review.
Accumulating evidence points to a critical role for the gut microbiome in regulating normal functioning of this axis. In particular, it is becoming clear that the microbial influence on tryptophan metabolism and the serotonergic system may be an important node in su …
Accumulating evidence points to a critical role for the gut microbiome in regulating normal functioning of this axis. In particular, …
Focus on the essentials: tryptophan metabolism and the microbiome-gut-brain axis.
Gheorghe CE, Martin JA, Manriquez FV, Dinan TG, Cryan JF, Clarke G. Gheorghe CE, et al. Curr Opin Pharmacol. 2019 Oct;48:137-145. doi: 10.1016/j.coph.2019.08.004. Epub 2019 Oct 14. Curr Opin Pharmacol. 2019. PMID: 31610413 Review.
Recent research has increasingly concentrated on tryptophan, the precursor to 5-HT and on the microbial regulation of tryptophan metabolism, with an emphasis on host-microbe control over kynurenine pathway metabolism and microbial-specific pathways that generate bio …
Recent research has increasingly concentrated on tryptophan, the precursor to 5-HT and on the microbial regulation of tryptophan
The Microbiome-Gut-Brain Axis in Health and Disease.
Dinan TG, Cryan JF. Dinan TG, et al. Gastroenterol Clin North Am. 2017 Mar;46(1):77-89. doi: 10.1016/j.gtc.2016.09.007. Epub 2017 Jan 4. Gastroenterol Clin North Am. 2017. PMID: 28164854 Review.
Irritable bowel syndrome is regarded as the prototypic disorder of the brain-gut-microbiota axis that can be responsive to probiotic therapy. ...Manipulating the gut microbiota with psychobiotics, prebiotics, or even antibiotics offers a novel approach to altering b …
Irritable bowel syndrome is regarded as the prototypic disorder of the brain-gut-microbiota axis that can be responsive to probiotic …
Impact of the Gut Microbiota on Intestinal Immunity Mediated by Tryptophan Metabolism.
Gao J, Xu K, Liu H, Liu G, Bai M, Peng C, Li T, Yin Y. Gao J, et al. Front Cell Infect Microbiol. 2018 Feb 6;8:13. doi: 10.3389/fcimb.2018.00013. eCollection 2018. Front Cell Infect Microbiol. 2018. PMID: 29468141 Free PMC article. Review.
In addition to serving as a nutrient enhancer, L-tryptophan (Trp) plays crucial roles in the balance between intestinal immune tolerance and gut microbiota maintenance. ...Moreover, Trp, endogenous Trp metabolites (kynurenines, serotonin, and melatonin), and bacteri …
In addition to serving as a nutrient enhancer, L-tryptophan (Trp) plays crucial roles in the balance between intestinal immune tolera …
Kynurenines: Tryptophan's metabolites in exercise, inflammation, and mental health.
Cervenka I, Agudelo LZ, Ruas JL. Cervenka I, et al. Science. 2017 Jul 28;357(6349):eaaf9794. doi: 10.1126/science.aaf9794. Science. 2017. PMID: 28751584 Review.
Kynurenine metabolites are generated by tryptophan catabolism and regulate biological processes that include host-microbiome signaling, immune cell response, and neuronal excitability. ...Here, we discuss peripheral mechanisms of tryptophan-kynurenine metabol …
Kynurenine metabolites are generated by tryptophan catabolism and regulate biological processes that include host-microbiome s …
Gut Microbiota Regulation of Tryptophan Metabolism in Health and Disease.
Agus A, Planchais J, Sokol H. Agus A, et al. Cell Host Microbe. 2018 Jun 13;23(6):716-724. doi: 10.1016/j.chom.2018.05.003. Cell Host Microbe. 2018. PMID: 29902437 Free article. Review.
Among the array of metabolites at the interface between these microorganisms and the host is the essential aromatic amino acid tryptophan (Trp). ...In this review, we gather the most recent advances concerning the central role of Trp metabolism in microbiota-host cr …
Among the array of metabolites at the interface between these microorganisms and the host is the essential aromatic amino acid tryptophan
The role of inflammation and the gut microbiome in depression and anxiety.
Peirce JM, Alviña K. Peirce JM, et al. J Neurosci Res. 2019 Oct;97(10):1223-1241. doi: 10.1002/jnr.24476. Epub 2019 May 29. J Neurosci Res. 2019. PMID: 31144383 Review.
Lastly, we provide an overview of gut microbiome-derived compounds (short-chain fatty acids, tryptophan catabolites, microbial pattern recognition) and related mechanisms (vagal nerve activity and fecal microbiota transplants) involved in mediating the influe …
Lastly, we provide an overview of gut microbiome-derived compounds (short-chain fatty acids, tryptophan catabolites, microbial …
The Brain-Gut-Microbiome Axis.
Martin CR, Osadchiy V, Kalani A, Mayer EA. Martin CR, et al. Cell Mol Gastroenterol Hepatol. 2018 Apr 12;6(2):133-148. doi: 10.1016/j.jcmgh.2018.04.003. eCollection 2018. Cell Mol Gastroenterol Hepatol. 2018. PMID: 30023410 Free PMC article. Review.
The brain can affect the community structure and function of the gut microbiota through the autonomic nervous system, by modulating regional gut motility, intestinal transit and secretion, and gut permeability, and potentially through the luminal secretion of hormones that …
The brain can affect the community structure and function of the gut microbiota through the autonomic nervous system, by modulating r …
Impacts of microbiome metabolites on immune regulation and autoimmunity.
Haase S, Haghikia A, Wilck N, Müller DN, Linker RA. Haase S, et al. Immunology. 2018 Jun;154(2):230-238. doi: 10.1111/imm.12933. Epub 2018 Apr 30. Immunology. 2018. PMID: 29637999 Free PMC article. Review.
Specific components of the gut microbiome have been implicated in the production of pro-inflammatory cytokines and subsequent generation of Th17 cells. ...Tryptophan metabolites may suppress inflammatory responses by acting on the aryl hydrocarbon receptor in T-cell …
Specific components of the gut microbiome have been implicated in the production of pro-inflammatory cytokines and subsequent generat …
Influence of Tryptophan and Serotonin on Mood and Cognition with a Possible Role of the Gut-Brain Axis.
Jenkins TA, Nguyen JC, Polglaze KE, Bertrand PP. Jenkins TA, et al. Nutrients. 2016 Jan 20;8(1):56. doi: 10.3390/nu8010056. Nutrients. 2016. PMID: 26805875 Free PMC article. Review.
An influence of gut microbiota on behaviour is becoming increasingly evident, as is the extension to tryptophan and serotonin, producing a possibility that alterations in the gut may be important in the pathophysiology of human central nervous system disorders. In t …
An influence of gut microbiota on behaviour is becoming increasingly evident, as is the extension to tryptophan and serotonin, …
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