Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation

Search Page

Filters

My Custom Filters

Edit custom filters

Results by year

Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1975 1
1997 2
1998 1
1999 1
2001 1
2006 1
2009 1
2010 1
2011 1
2013 1
2014 1
2016 1
2018 3
2019 2
2020 4
2021 3
2022 1
2023 1
2024 4
2025 4
2026 2

Publication date

Text availability

Article attribute

Article type

Additional filters

Article Language

Species

Sex

Age

Other

Search Results

33 results

Results by year

Filters applied: . Clear all
Page 1
Lactalbumin, Not Collagen, Augments Muscle Protein Synthesis with Aerobic Exercise.
Oikawa SY, Macinnis MJ, Tripp TR, McGlory C, Baker SK, Phillips SM. Oikawa SY, et al. Med Sci Sports Exerc. 2020 Jun;52(6):1394-1403. doi: 10.1249/MSS.0000000000002253. Med Sci Sports Exerc. 2020. PMID: 31895298
INTRODUCTION: Protein ingestion and the ensuing hyperaminoacidemia stimulates skeletal muscle protein synthesis in the postexercise period. ...CONCLUSIONS: Despite an isonitrogenous diet, protein synthesis was enhanced to a greater extent …
INTRODUCTION: Protein ingestion and the ensuing hyperaminoacidemia stimulates skeletal muscle protein synthesis …
Kynurenic Acid and Gpr35 Regulate Adipose Tissue Energy Homeostasis and Inflammation.
Agudelo LZ, Ferreira DMS, Cervenka I, Bryzgalova G, Dadvar S, Jannig PR, Pettersson-Klein AT, Lakshmikanth T, Sustarsic EG, Porsmyr-Palmertz M, Correia JC, Izadi M, Martínez-Redondo V, Ueland PM, Midttun Ø, Gerhart-Hines Z, Brodin P, Pereira T, Berggren PO, Ruas JL. Agudelo LZ, et al. Cell Metab. 2018 Feb 6;27(2):378-392.e5. doi: 10.1016/j.cmet.2018.01.004. Cell Metab. 2018. PMID: 29414686 Free article.
The role of tryptophan-kynurenine metabolism in psychiatric disease is well established, but remains less explored in peripheral tissues. Exercise training activates kynurenine biotransformation in skeletal muscle, which protects from neuroinflammation …
The role of tryptophan-kynurenine metabolism in psychiatric disease is well established, but remains less explored in peripher …
The kynurenine connection: how exercise shifts muscle tryptophan metabolism and affects energy homeostasis, the immune system, and the brain.
Martin KS, Azzolini M, Lira Ruas J. Martin KS, et al. Am J Physiol Cell Physiol. 2020 May 1;318(5):C818-C830. doi: 10.1152/ajpcell.00580.2019. Epub 2020 Mar 25. Am J Physiol Cell Physiol. 2020. PMID: 32208989 Free article. Review.
Physical exercise can modulate kynurenine pathway metabolism in skeletal muscle and thus change the concentrations of select compounds in peripheral tissues and in the central nervous system. Here we review recent advances in our understanding of how exerc …
Physical exercise can modulate kynurenine pathway metabolism in skeletal muscle and thus change the concentrations of s …
Activation of the Aryl Hydrocarbon Receptor in Muscle Exacerbates Ischemic Pathology in Chronic Kidney Disease.
Balestrieri N, Palzkill V, Pass C, Tan J, Salyers ZR, Moparthy C, Murillo A, Kim K, Thome T, Yang Q, O'Malley KA, Berceli SA, Yue F, Scali ST, Ferreira LF, Ryan TE. Balestrieri N, et al. Circ Res. 2023 Jul 7;133(2):158-176. doi: 10.1161/CIRCRESAHA.123.322875. Epub 2023 Jun 16. Circ Res. 2023. PMID: 37325935 Free PMC article.
METHODS: AHR-related gene expression was evaluated in skeletal muscle obtained from mice and human PAD patients with and without CKD. AHR(mKO) (skeletal muscle-specific AHR knockout) mice with and without CKD were subjected to femoral artery ligation, and a battery …
METHODS: AHR-related gene expression was evaluated in skeletal muscle obtained from mice and human PAD patients with and without CKD. …
A tryptophan-derived uremic metabolite/Ahr/Pdk4 axis governs skeletal muscle mitochondrial energetics in chronic kidney disease.
Thome T, Vugman NA, Stone LE, Wimberly K, Scali ST, Ryan TE. Thome T, et al. JCI Insight. 2024 Apr 23;9(10):e178372. doi: 10.1172/jci.insight.178372. JCI Insight. 2024. PMID: 38652558 Free PMC article.
Chronic kidney disease (CKD) causes accumulation of uremic metabolites that negatively affect skeletal muscle. Tryptophan-derived uremic metabolites are agonists of the aryl hydrocarbon receptor (AHR), which has been shown to be activated in CKD. ...In mice with CKD …
Chronic kidney disease (CKD) causes accumulation of uremic metabolites that negatively affect skeletal muscle. Tryptophan-deri …
Why Osteosarcopenia Matters: Clinical and Investigative Implications.
Bonamigo EL, Maia MN, Pinheiro Cavallaro de Oliveira R, Gemerasca Mestriner R, Aprahamian I, Duque G. Bonamigo EL, et al. Eur J Clin Invest. 2026 May;56(5):e70221. doi: 10.1111/eci.70221. Eur J Clin Invest. 2026. PMID: 42135934 Free PMC article. Review.
RESULTS: The occurrence of osteosarcopenia reflects the combined impact of low bone mineral density (BMD), loss of muscle mass and strength, and age-related metabolic changes such as chronic inflammation, lipotoxicity, and disruptions in tryptophan (TRP) metaboli …
RESULTS: The occurrence of osteosarcopenia reflects the combined impact of low bone mineral density (BMD), loss of muscle mass and st …
Exercise training impacts skeletal muscle gene expression related to the kynurenine pathway.
Allison DJ, Nederveen JP, Snijders T, Bell KE, Kumbhare D, Phillips SM, Parise G, Heisz JJ. Allison DJ, et al. Am J Physiol Cell Physiol. 2019 Mar 1;316(3):C444-C448. doi: 10.1152/ajpcell.00448.2018. Epub 2019 Jan 16. Am J Physiol Cell Physiol. 2019. PMID: 30649918 Free PMC article. Clinical Trial.
Recent evidence highlights a potential role for skeletal muscle-derived transcription factors to influence tryptophan metabolism, along the kynurenine pathway, which has important implications in depression. ...The aim of the present study was to examine the …
Recent evidence highlights a potential role for skeletal muscle-derived transcription factors to influence tryptophan metab …
Exhaustive exercise abolishes REV-ERB-alpha circadian rhythm and shifts the kynurenine pathway to a neurotoxic profile in mice.
da Rocha AL, Pinto AP, de Sousa Neto IV, Muñoz VR, Marafon BB, da Silva LECM, Pauli JR, Cintra DE, Ropelle ER, Simabuco FM, de Moura LP, de Freitas EC, Rivas DA, da Silva ASR. da Rocha AL, et al. J Physiol. 2025 Jul;603(14):3923-3944. doi: 10.1113/JP288290. Epub 2025 Jun 24. J Physiol. 2025. PMID: 40554695 Free PMC article.
The circadian-regulated transcriptional repressor REV-ERB-alpha is a key mediator of skeletal muscle oxidative capacity, enhancing exercise performance when activated. Conversely its global genetic ablation leads to impaired performance. ...Although REV-ERB-alpha ac …
The circadian-regulated transcriptional repressor REV-ERB-alpha is a key mediator of skeletal muscle oxidative capacity, enhancing …
The weight of nutrients: kynurenine metabolites in obesity and exercise.
Dadvar S, Ferreira DMS, Cervenka I, Ruas JL. Dadvar S, et al. J Intern Med. 2018 Nov;284(5):519-533. doi: 10.1111/joim.12830. Epub 2018 Sep 25. J Intern Med. 2018. PMID: 30141532 Free article. Review.
Tryptophan-kynurenine metabolites are an example of a family of compounds that can serve as systemic integrators of energy metabolism by signalling to different cell types. ...In the context of energy metabolism, several of the effects elicited by kynurenic a …
Tryptophan-kynurenine metabolites are an example of a family of compounds that can serve as systemic integrators of energy metabol …
Facts and fallacies of purported ergogenic amino acid supplements.
Williams MH. Williams MH. Clin Sports Med. 1999 Jul;18(3):633-49. doi: 10.1016/s0278-5919(05)70173-3. Clin Sports Med. 1999. PMID: 10410846 Review.
Although some research suggests that the induction of hyperaminoacidemia via intravenous infusion of a balanced amino acid mixture may induce an increased muscle protein synthesis after exercise, no data support the finding that oral supplementation wi …
Although some research suggests that the induction of hyperaminoacidemia via intravenous infusion of a balanced amino acid mixture may induc …
33 results