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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1983 1
1988 1
1989 1
1990 2
1992 1
1993 3
1995 3
1996 4
1997 3
1998 1
1999 3
2000 5
2001 10
2002 5
2003 6
2004 10
2005 8
2006 21
2007 12
2008 11
2009 26
2010 19
2011 22
2012 23
2013 26
2014 29
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2026 71

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744 results

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Page 1
Micronutrient antioxidant supplementation alleviates valproic acid-induced oxidative stress and male infertility via the NRF2/HO-1 pathway.
Asghar MA, Wan B, Li L, Zhang J, Tang S, Han H, Yang Y, Chu L, Zhang Q, Zhang X, Zhao Q. Asghar MA, et al. Redox Biol. 2025 Sep;85:103685. doi: 10.1016/j.redox.2025.103685. Epub 2025 May 29. Redox Biol. 2025. PMID: 40505349 Free PMC article.
In vitro studies with GC-2spd(ts) and HepG2 cells confirmed that antioxidants alleviated VPA-induced oxidative stress. Network pharmacology identified key molecular targets, such as GPX4, SOD1, HO-1, and NRF2, which are involved in oxidative stress …
In vitro studies with GC-2spd(ts) and HepG2 cells confirmed that antioxidants alleviated VPA-induced oxidative stress. …
Oxidative and Nitrosative Stress as Well as the Tryptophan Catabolites Pathway in Depressive Disorders.
Wigner P, Czarny P, Galecki P, Sliwinski T. Wigner P, et al. Psychiatr Danub. 2017 Dec;29(4):394-400. doi: 10.24869/psyd.2017.394. Psychiatr Danub. 2017. PMID: 29197195 Free article. Review.
The aim of this paper is to elucidate the role of oxidative and nitrosative stress as well as the tryptophan catabolites pathway in the development of depression and the mechanism of action of antidepressant drugs, based on the available literature. ...There …
The aim of this paper is to elucidate the role of oxidative and nitrosative stress as well as the tryptophan catabolite …
Quinic acid alleviates high-fat diet-induced neuroinflammation by inhibiting DR3/IKK/NF-kappaB signaling via gut microbial tryptophan metabolites.
Li S, Cai Y, Guan T, Zhang Y, Huang K, Zhang Z, Cao W, Guan X. Li S, et al. Gut Microbes. 2024 Jan-Dec;16(1):2374608. doi: 10.1080/19490976.2024.2374608. Epub 2024 Jul 7. Gut Microbes. 2024. PMID: 38972055 Free PMC article.
With the increasing of aging population and the consumption of high-fat diets (HFD), the incidence of Alzheimer's disease (AD) has skyrocketed. Natural antioxidants show promising potential in the prevention of AD, as oxidative stress and neuroinflammation ar …
With the increasing of aging population and the consumption of high-fat diets (HFD), the incidence of Alzheimer's disease (AD) has skyrocket …
Butyrate Rescues Oxidative Stress-Induced Transport Deficits of Tryptophan: Potential Implication in Affective or Gut-Brain Axis Disorders.
Rode J, Yang L, König J, Hutchinson AN, Wall R, Venizelos N, Brummer RJ, Rangel I, Vumma R. Rode J, et al. Neuropsychobiology. 2021;80(3):253-263. doi: 10.1159/000510886. Epub 2020 Oct 19. Neuropsychobiology. 2021. PMID: 33075780
OBJECTIVE: Here, we evaluated the negative effect of oxidative stress on the transport of the serotonin precursor tryptophan as present in affective disorders. ...Furthermore, gene expression profiles of different amino acid transporters were analyzed (n = 2) …
OBJECTIVE: Here, we evaluated the negative effect of oxidative stress on the transport of the serotonin precursor tryptopha …
Depression like-behavior and memory loss induced by methylglyoxal is associated with tryptophan depletion and oxidative stress: a new in vivo model of neurodegeneration.
Md Samsuzzaman, Hong SM, Lee JH, Park H, Chang KA, Kim HB, Park MG, Eo H, Oh MS, Kim SY. Md Samsuzzaman, et al. Biol Res. 2024 Nov 21;57(1):87. doi: 10.1186/s40659-024-00572-4. Biol Res. 2024. PMID: 39574138 Free PMC article.
RESULTS: We investigated the effect of MGO stress on depression like-behavior and memory loss to elucidate the potential interplay between MGO-induced tryptophan (Trp) metabolism impairment and oxidative stress in the brain. ...Likewise, Trp treatment …
RESULTS: We investigated the effect of MGO stress on depression like-behavior and memory loss to elucidate the potential interplay be …
Tryptophan improves antioxidant capability and meat quality by reducing responses to stress in nervous Hu sheep.
Wang J, Ding L, Yu X, Wu F, Zhang J, Chen P, Qian S, Wang M. Wang J, et al. Meat Sci. 2023 Oct;204:109267. doi: 10.1016/j.meatsci.2023.109267. Epub 2023 Jun 24. Meat Sci. 2023. PMID: 37392733
In sheep, the effect of tryptophan (Trp) on behavioural traits that are associated with temperament and any effects on production traits is unknown. ...The findings in this study suggested the Hu sheep with calm temperament would experience less stress during produc …
In sheep, the effect of tryptophan (Trp) on behavioural traits that are associated with temperament and any effects on production tra …
Resveratrol Alleviating the Ovarian Function Under Oxidative Stress by Alternating Microbiota Related Tryptophan-Kynurenine Pathway.
Wang J, Jia R, Celi P, Zhuo Y, Ding X, Zeng Q, Bai S, Xu S, Yin H, Lv L, Zhang K. Wang J, et al. Front Immunol. 2022 Jul 13;13:911381. doi: 10.3389/fimmu.2022.911381. eCollection 2022. Front Immunol. 2022. PMID: 35911670 Free PMC article.
Oxidative stress (OS) is a key factor regulating the systemic pathophysiological effects and one of the fundamental mechanisms associated with aging and fertility deterioration. ...These findings indicated that the intestinal microbiota-related tryptophan-kyn …
Oxidative stress (OS) is a key factor regulating the systemic pathophysiological effects and one of the fundamental mechanisms …
The Tryptophan Pathway Targeting Antioxidant Capacity in the Placenta.
Xu K, Liu G, Fu C. Xu K, et al. Oxid Med Cell Longev. 2018 Jul 22;2018:1054797. doi: 10.1155/2018/1054797. eCollection 2018. Oxid Med Cell Longev. 2018. PMID: 30140360 Free PMC article. Review.
Dysfunction of the placenta can be caused by oxidative stress and can lead to abnormal fetal development. Preventing oxidative stress of the placenta is thus an important measure to ensure positive birth outcomes. ...Two predicted mechanisms of tryp …
Dysfunction of the placenta can be caused by oxidative stress and can lead to abnormal fetal development. Preventing oxidat …
The Interrelation between Oxidative Stress, Depression and Inflammation through the Kynurenine Pathway.
Sipahi H, Mat AF, Ozhan Y, Aydin A. Sipahi H, et al. Curr Top Med Chem. 2023;23(6):415-425. doi: 10.2174/1568026623666221223111309. Curr Top Med Chem. 2023. PMID: 36567285 Review.
Moreover, there is a bidirectional relationship between oxidative stress and inflammation. Oxidative stress plays a pathogenic role in chronic inflammatory diseases; depressive disorder is being suggested as one of them. Recent research using several …
Moreover, there is a bidirectional relationship between oxidative stress and inflammation. Oxidative stress play …
A Transcriptomics Approach to Unveil the Antioxidant Effects of Tryptophan on Oocyte Quality Under Oxidative Stress in Pigs.
Zhu Z, Li Y, Fan X, Cai S, Li S, Wang Y, Wang X, Yang F. Zhu Z, et al. Biomolecules. 2025 Jun 30;15(7):949. doi: 10.3390/biom15070949. Biomolecules. 2025. PMID: 40723821 Free PMC article.
This study investigates the effect of tryptophan treatment on aged pig oocytes, focusing on its potential to reduce oxidative stress and improve oocyte quality. ...Furthermore, tryptophan improved cumulus cell expansion, and oocyte quality, which were …
This study investigates the effect of tryptophan treatment on aged pig oocytes, focusing on its potential to reduce oxidative …
744 results