Tryptophan supplementation and postoperative delirium--a randomized controlled trial.
J Am Geriatr Soc. 2014.
PMID: 25112175
Free PMC article.
Clinical Trial.
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Tryptophan, glutamine, leucine, and micronutrient supplementation improves environmental enteropathy in Zambian adults: a randomized controlled trial.
Am J Clin Nutr. 2019.
PMID: 31504110
Free PMC article.
Clinical Trial.
Tryptophan-enriched diet or 5-hydroxytryptophan supplementation given in a randomized controlled trial impacts social cognition on a neural and behavioral level.
Sci Rep. 2021.
PMID: 34737364
Free PMC article.
Clinical Trial.
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The impact of 5-hydroxytryptophan supplementation on sleep quality and gut microbiota composition in older adults: A randomized controlled trial.
Clin Nutr. 2024 Mar;43(3):593-602. doi: 10.1016/j.clnu.2024.01.010. Epub 2024 Jan 17.
Clin Nutr. 2024.
PMID: 38309227
Clinical Trial.
METHODS: This is a single-blinded, 12-week parallel randomized controlled trial. Thirty older adults (66 3 years) in Singapore were randomly assigned to either consume or not consume 100 mg 5-HTP daily. ...In particular, at week 12, not good sleepers but po …
METHODS: This is a single-blinded, 12-week parallel randomized controlled trial. Thirty older adults (66 3 years) in …
A systematic review of the effect of L-tryptophan supplementation on mood and emotional functioning.
J Diet Suppl. 2021;18(3):316-333. doi: 10.1080/19390211.2020.1746725. Epub 2020 Apr 10.
J Diet Suppl. 2021.
PMID: 32272859
L-tryptophan (TRP), one of the essential amino acids in humans, is a precursor of serotonin, and hence its intake is closely related to the suppression of depressed and anxious moods. We did a systematic review of RCTs to examine the effects of tryptophan intake on …
L-tryptophan (TRP), one of the essential amino acids in humans, is a precursor of serotonin, and hence its intake is closely related …
Serotonin a la carte: supplementation with the serotonin precursor 5-hydroxytryptophan.
Pharmacol Ther. 2006 Mar;109(3):325-38. doi: 10.1016/j.pharmthera.2005.06.004. Epub 2005 Jul 14.
Pharmacol Ther. 2006.
PMID: 16023217
Free article.
Review.
This paper reviews the preclinical and clinical evidence regarding the use of the dietary supplement 5-hydroxytryptophan (5-HTP) for the treatment of depression. In the absence of supplementation with exogenous 5-HTP, the amount of endogenous 5-HTP available for serotonin …
This paper reviews the preclinical and clinical evidence regarding the use of the dietary supplement 5-hydroxytryptophan (5-HTP) for the tre …
Gut microbiota indole-3-propionic acid mediates neuroprotective effect of probiotic consumption in healthy elderly: A randomized, double-blind, placebo-controlled, multicenter trial and in vitro study.
Clin Nutr. 2023 Jun;42(6):1025-1033. doi: 10.1016/j.clnu.2023.04.001. Epub 2023 May 2.
Clin Nutr. 2023.
PMID: 37150125
Free article.
Clinical Trial.
RESULTS: The metabolomic profiling analyses showed that probiotic consumption significantly altered the levels of metabolites involved in tryptophan metabolism (P < 0.01). Among these metabolites, gut microbiota-produced IPA had a 1.91-fold increase in the probiotics gr
…
RESULTS: The metabolomic profiling analyses showed that probiotic consumption significantly altered the levels of metabolites involved in …
Effect of probiotic and prebiotic vs placebo on psychological outcomes in patients with major depressive disorder: A randomized clinical trial.
Clin Nutr. 2019 Apr;38(2):522-528. doi: 10.1016/j.clnu.2018.04.010. Epub 2018 Apr 24.
Clin Nutr. 2019.
PMID: 29731182
Clinical Trial.
OBJECTIVE: The aim of this double blind clinical trial, was to compare the effect of supplementation with the probiotic and prebiotic on the Beck Depression Inventory (BDI) score as a primary outcome as well as the kynurenine/tryptophan ratio and tryptophan/b …
OBJECTIVE: The aim of this double blind clinical trial, was to compare the effect of supplementation with the probiotic and prebiotic …
Effects of Coenzyme Q10, Tryptophan, and Magnesium Supplementation on Fatigue in Patients with Fibromyalgia - A Randomized Trial.
J Diet Suppl. 2025;22(3):433-444. doi: 10.1080/19390211.2025.2483269. Epub 2025 Mar 28.
J Diet Suppl. 2025.
PMID: 40151031
Clinical Trial.
Coenzyme Q10 (CoQ10), magnesium, and tryptophan are associated with FM symptoms, but their combined effects in this condition are poorly understood. The objective of the study was to assess the effects of CoQ10, tryptophan, and magnesium supplementation in pa …
Coenzyme Q10 (CoQ10), magnesium, and tryptophan are associated with FM symptoms, but their combined effects in this condition are poo …
Tryptophan supplementation and postoperative delirium--a randomized controlled trial.
J Am Geriatr Soc. 2014 Sep;62(9):1764-71. doi: 10.1111/jgs.12972. Epub 2014 Aug 12.
J Am Geriatr Soc. 2014.
PMID: 25112175
Free PMC article.
Clinical Trial.
Forty percent of participants in the tryptophan group and 37% in the placebo group had overall delirium (P = .60), and the duration of overall delirium was 2.9 1.8 days for tryptophan and 2.4 1.6 days for placebo (P = .17). CONCLUSION: Postoperative tryptopha …
Forty percent of participants in the tryptophan group and 37% in the placebo group had overall delirium (P = .60), and the duration o …
The Impact of 5-Hydroxytryptophan Supplementation on Cognitive Function and Mood in Singapore Older Adults: A Randomized Controlled Trial.
Nutrients. 2025 Aug 27;17(17):2773. doi: 10.3390/nu17172773.
Nutrients. 2025.
PMID: 40944161
Free PMC article.
Clinical Trial.
Therefore, the study aimed to investigate the effects of 5-HTP supplementation on cognitive function and mood in Singaporean older adults. Methods: This was a single-blinded, 12-week randomized controlled trial, and 30 participants (66 3 years) were …
Therefore, the study aimed to investigate the effects of 5-HTP supplementation on cognitive function and mood in Singaporean older ad …
Effect of 5-Hydroxytryptophan on Fatigue in Quiescent Inflammatory Bowel Disease: A Randomized Controlled Trial.
Gastroenterology. 2022 Nov;163(5):1294-1305.e3. doi: 10.1053/j.gastro.2022.07.052. Epub 2022 Aug 6.
Gastroenterology. 2022.
PMID: 35940251
Free article.
Clinical Trial.
Based on the hypothetical link between low serum tryptophan concentrations and fatigue, we determined the effect of 5-hydroxytryptophan supplementation on fatigue in patients with inactive IBD. METHODS: A multicenter randomized controlled trial …
Based on the hypothetical link between low serum tryptophan concentrations and fatigue, we determined the effect of 5-hydroxytryptoph …
The effect of prebiotic supplementation on serum levels of tryptophan and kynurenine in obese women with major depressive disorder: a double-blinded placebo-controlled randomized clinical trial.
BMC Res Notes. 2024 Oct 20;17(1):316. doi: 10.1186/s13104-024-06963-w.
BMC Res Notes. 2024.
PMID: 39428497
Free PMC article.
Clinical Trial.
OBJECTIVE: The objective of the present study was to examine the effect of calorie restricted diet (CRD) plus inulin supplementation on serum levels of tryptophan (Trp), kynurenine (Kyn) and Trp/Kyn ratio in obese women with major depressive disorder (MDD). ...Resul …
OBJECTIVE: The objective of the present study was to examine the effect of calorie restricted diet (CRD) plus inulin supplementation …
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