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Peroxisome proliferator-activated receptor-gamma (PPARgamma) agonist is neuroprotective and stimulates PGC-1alpha expression and CREB phosphorylation in human dopaminergic neurons.
Mäkelä J, Tselykh TV, Kukkonen JP, Eriksson O, Korhonen LT, Lindholm D. Mäkelä J, et al. Among authors: tselykh tv. Neuropharmacology. 2016 Mar;102:266-75. doi: 10.1016/j.neuropharm.2015.11.020. Epub 2015 Nov 26. Neuropharmacology. 2016. PMID: 26631533
The enhanced resilience of the neurons was attributed to increased levels of mitochondrial antioxidants and of PGC-1alpha. ...Together these results show that the PPARgamma agonist GW1929 influences CREB signaling and PGC-1alpha activities in the human dopaminergic neur
The enhanced resilience of the neurons was attributed to increased levels of mitochondrial antioxidants and of PGC-1alpha. ...Togethe …
Fibroblast growth factor-21 enhances mitochondrial functions and increases the activity of PGC-1alpha in human dopaminergic neurons via Sirtuin-1.
Mäkelä J, Tselykh TV, Maiorana F, Eriksson O, Do HT, Mudò G, Korhonen LT, Belluardo N, Lindholm D. Mäkelä J, et al. Among authors: tselykh tv. Springerplus. 2014 Jan 2;3:2. doi: 10.1186/2193-1801-3-2. eCollection 2014. Springerplus. 2014. PMID: 25932355 Free PMC article.
FGF21 also enhanced mitochondrial respiratory capacity in human dopaminergic neurons as shown in real-time analyses of living cells. FGF21 is present in the brain including midbrain and is expressed by glial cells in culture. These results show that FGF21 activates PGC-1al …
FGF21 also enhanced mitochondrial respiratory capacity in human dopaminergic neurons as shown in real-time analyses of living cells. …
Reciprocal regulation of very low density lipoprotein receptors (VLDLRs) in neurons by brain-derived neurotrophic factor (BDNF) and Reelin: involvement of the E3 ligase Mylip/Idol.
Do HT, Bruelle C, Tselykh T, Jalonen P, Korhonen L, Lindholm D. Do HT, et al. Among authors: tselykh t. J Biol Chem. 2013 Oct 11;288(41):29613-20. doi: 10.1074/jbc.M113.500967. Epub 2013 Aug 29. J Biol Chem. 2013. PMID: 23990472 Free PMC article.
We show here that BDNF increased the levels of the Reelin receptor (VLDL receptor (VLDLR)) in hippocampal neurons by increasing gene expression. In contrast, Reelin decreased VLDLRs, which was accompanied by an increase in the levels of the E3 ligase Mylip/Idol in neuro
We show here that BDNF increased the levels of the Reelin receptor (VLDL receptor (VLDLR)) in hippocampal neurons by increasing gene …