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Year Number of Results
1974 1
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1983 10
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1987 29
1988 63
1989 121
1990 291
1991 605
1992 1021
1993 1522
1994 2118
1995 2495
1996 2848
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1998 3523
1999 3813
2000 4090
2001 4212
2002 4253
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2005 4486
2006 4544
2007 4645
2008 4801
2009 4729
2010 5212
2011 5655
2012 5741
2013 5926
2014 6169
2015 6353
2016 5986
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2019 5488
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139,877 results

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Page 1
The TP53 tumor suppressor gene: From molecular biology to clinical investigations.
Baliakas P, Soussi T. Baliakas P, et al. J Intern Med. 2025 Aug;298(2):78-96. doi: 10.1111/joim.20106. Epub 2025 Jun 16. J Intern Med. 2025. PMID: 40524430 Free PMC article. Review.
Extensively studied over the past four decades, the TP53 gene has emerged as a pivotal watchman in cellular defense and a key factor in cancer biology. ...Mutations in p53 are associated with poor response to therapy and shorter survival in most cancer types, and the diagn …
Extensively studied over the past four decades, the TP53 gene has emerged as a pivotal watchman in cellular defense and a key factor …
Mosaicism in Tumor Suppressor Gene Syndromes: Prevalence, Diagnostic Strategies, and Transmission Risk.
Chen JL, Miller DT, Schmidt LS, Malkin D, Korf BR, Eng C, Kwiatkowski DJ, Giannikou K. Chen JL, et al. Annu Rev Genomics Hum Genet. 2022 Aug 31;23:331-361. doi: 10.1146/annurev-genom-120121-105450. Annu Rev Genomics Hum Genet. 2022. PMID: 36044908 Free article. Review.
Here, we review the current state of knowledge regarding mosaicism for eight common tumor suppressor genes-NF1, NF2, TSC1, TSC2, PTEN, VHL, RB1, and TP53-and their related genetic syndromes/entities. ...We also review affected individuals who have no mutation …
Here, we review the current state of knowledge regarding mosaicism for eight common tumor suppressor genes-NF1, NF2, TS …
Retinoblastoma and tumor-suppressor gene therapy.
Xu HJ. Xu HJ. Ophthalmol Clin North Am. 2003 Dec;16(4):621-9. doi: 10.1016/s0896-1549(03)00065-8. Ophthalmol Clin North Am. 2003. PMID: 14741002 Review.
Retinoblastoma as a genetic disease is a paradigm for tumor-suppressor gene theory. The RB gene is one of the best-studied tumor-suppressor genes with known key functions in controlling cell proliferation and differentiation. ...RB …
Retinoblastoma as a genetic disease is a paradigm for tumor-suppressor gene theory. The RB gene is one of the be …
WWOX tumor suppressor gene.
Yang J, Zhang W. Yang J, et al. Histol Histopathol. 2008 Jul;23(7):877-82. doi: 10.14670/HH-23.877. Histol Histopathol. 2008. PMID: 18437686 Free article. Review.
The evidence from cancer cell lines and primary tumor tissues suggests that WWOX is a tumor suppressor gene and that its inactivation contributes to cancer development. ...However, there is not universal agreement that WWOX is a tumor suppres …
The evidence from cancer cell lines and primary tumor tissues suggests that WWOX is a tumor suppressor gene and …
TP53 tumor suppressor gene and skin carcinogenesis.
Basset-Séguin N, Molès JP, Mils V, Dereure O, Guilhou JJ. Basset-Séguin N, et al. J Invest Dermatol. 1994 Nov;103(5 Suppl):102S-106S. doi: 10.1111/1523-1747.ep12399372. J Invest Dermatol. 1994. PMID: 7963669 Free article. Review.
The tumor suppressor gene TP53 encodes for a nuclear phosphoprotein involved in the control of cell proliferation, particularly in stressed cells. TP53 gene mutations are the most frequent genetic event found in human cancers. Most mutations locate in …
The tumor suppressor gene TP53 encodes for a nuclear phosphoprotein involved in the control of cell proliferation, part …
The RB1 Story: Characterization and Cloning of the First Tumor Suppressor Gene.
Berry JL, Polski A, Cavenee WK, Dryja TP, Murphree AL, Gallie BL. Berry JL, et al. Genes (Basel). 2019 Nov 1;10(11):879. doi: 10.3390/genes10110879. Genes (Basel). 2019. PMID: 31683923 Free PMC article. Review.
The RB1 gene is the first described human tumor suppressor gene and plays an integral role in the development of retinoblastoma, a pediatric malignancy of the eye. Since its discovery, the stepwise characterization and cloning of RB1 have laid the foun …
The RB1 gene is the first described human tumor suppressor gene and plays an integral role in the development of …
Tumor-suppressor gene products in cell contacts: the cadherin-APC-armadillo connection.
Hülsken J, Behrens J, Birchmeier W. Hülsken J, et al. Curr Opin Cell Biol. 1994 Oct;6(5):711-6. doi: 10.1016/0955-0674(94)90098-1. Curr Opin Cell Biol. 1994. PMID: 7833051 Review.
Various structural components of intercellular junctions have recently been found to represent (or be related to) products of tumor-suppressor genes. The tumor-suppressor gene product adenomatous polyposis coli (APC) binds to beta 2-caten …
Various structural components of intercellular junctions have recently been found to represent (or be related to) products of tumor- …
WT1: a novel tumor suppressor gene inactivated in Wilms' tumor.
Haber DA, Buckler AJ. Haber DA, et al. New Biol. 1992 Feb;4(2):97-106. New Biol. 1992. PMID: 1313285 Review.
The development of Wilms' tumor, a pediatric kidney cancer, has been linked to the inactivation of a tumor suppressor gene both by epidemiologic studies and by genetic analyses. ...This gene has properties distinct from those of other known t …
The development of Wilms' tumor, a pediatric kidney cancer, has been linked to the inactivation of a tumor suppressor …
Tumor suppressor gene mutations in mice.
Jacks T. Jacks T. Annu Rev Genet. 1996;30:603-36. doi: 10.1146/annurev.genet.30.1.603. Annu Rev Genet. 1996. PMID: 8982467 Review.
Over the past several years, a number of human tumor suppressor genes have been cloned and characterized. Germline mutations in tumor suppressor genes strongly predispose to cancer, and they are also mutated somatically in sporadic forms …
Over the past several years, a number of human tumor suppressor genes have been cloned and characterized. Germline muta …
PTEN, a unique tumor suppressor gene.
Dahia PL. Dahia PL. Endocr Relat Cancer. 2000 Jun;7(2):115-29. doi: 10.1677/erc.0.0070115. Endocr Relat Cancer. 2000. PMID: 10903528 Free article. Review.
For many years, it has been thought that the chromosome region 10q22-24 includes one or more genes that appear to play a role in several human malignancies. PTEN is a new tumor suppressor gene encoding a dual-specificity phosphatase that was cloned sim …
For many years, it has been thought that the chromosome region 10q22-24 includes one or more genes that appear to play a role in seve …
139,877 results
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