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1982 1
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13,733 results

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Page 1
The FHIT gene product: tumor suppressor and genome "caretaker".
Waters CE, Saldivar JC, Hosseini SA, Huebner K. Waters CE, et al. Cell Mol Life Sci. 2014 Dec;71(23):4577-87. doi: 10.1007/s00018-014-1722-0. Epub 2014 Oct 5. Cell Mol Life Sci. 2014. PMID: 25283145 Free PMC article. Review.
The FHIT gene at FRA3B is one of the earliest and most frequently altered genes in the majority of human cancers. ...Indeed, recent reports have reconfirmed FHIT as a tumor suppressor gene with roles in apoptosis and prevention of the epithelial …
The FHIT gene at FRA3B is one of the earliest and most frequently altered genes in the majority of human cancers. ...Indeed, r …
The p53 tumor suppressor gene and gene product.
Levine AJ. Levine AJ. Princess Takamatsu Symp. 1989;20:221-30. Princess Takamatsu Symp. 1989. PMID: 2488233 Review.
Three lines of evidence suggest that the p53 gene and gene product may act as a negative regulator of growth or a tumor suppressor gene: (1) in several tumors of mice and humans, both of the p53 alleles have suffered mutations and in some …
Three lines of evidence suggest that the p53 gene and gene product may act as a negative regulator of growth or a tu …
The tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis.
Maxwell PH, Wiesener MS, Chang GW, Clifford SC, Vaux EC, Cockman ME, Wykoff CC, Pugh CW, Maher ER, Ratcliffe PJ. Maxwell PH, et al. Nature. 1999 May 20;399(6733):271-5. doi: 10.1038/20459. Nature. 1999. PMID: 10353251
Hypoxia-inducible factor-1 (HIF-1) has a key role in cellular responses to hypoxia, including the regulation of genes involved in energy metabolism, angiogenesis and apoptosis. The alpha subunits of HIF are rapidly degraded by the proteasome under normal conditions, but ar …
Hypoxia-inducible factor-1 (HIF-1) has a key role in cellular responses to hypoxia, including the regulation of genes involved in ene …
Cancer genes.
Vogt PK. Vogt PK. West J Med. 1993 Mar;158(3):273-8. West J Med. 1993. PMID: 8460509 Free PMC article.
Most cancers harbor multiple genetic changes in oncogenes as well as tumor suppressor genes. Oncogenes induce aberrant growth through a gain in function; tumor suppressor genes contribute to oncogenesis through a loss of function. ...Onco …
Most cancers harbor multiple genetic changes in oncogenes as well as tumor suppressor genes. Oncogenes induce aberrant …
Gene-targeting and the p53 tumor-suppressor gene.
Sands A, Donehower LA, Bradley A. Sands A, et al. Mutat Res. 1994 Jun 1;307(2):557-72. doi: 10.1016/0027-5107(94)90266-6. Mutat Res. 1994. PMID: 7514729 Review.
In addition, an application of gene-targeting is illustrated in the study of a class of genes with tumor-suppressor function. Recent findings from experiments using gene targeted mice to study the p53 tumor-suppressor gene a …
In addition, an application of gene-targeting is illustrated in the study of a class of genes with tumor-suppressor …
Tumor suppressor genes.
Lee NK. Lee NK. Head Neck. 1992 Sep-Oct;14(5):407-14. doi: 10.1002/hed.2880140513. Head Neck. 1992. PMID: 1399577 Review.
Tumor suppressor genes are negative regulators of cell growth. When their normal function is compromised, absence of their inhibitory effects can lead to unrestrained cell cycling and growth. Strong evidence now confirms that loss of proper function of these …
Tumor suppressor genes are negative regulators of cell growth. When their normal function is compromised, absence of th …
Oncogene- and tumor-suppressor gene-related proteins in plants and fungi.
Loidl A, Loidl P. Loidl A, et al. Crit Rev Oncog. 1996;7(1-2):49-64. doi: 10.1615/critrevoncog.v7.i1-2.40. Crit Rev Oncog. 1996. PMID: 9109497 Review.
Protooncogene- and tumor-suppressor gene proteins serve essential functions in the regulation of proliferation and differentiation of cells. ...A screening for nuclear protooncogene- and tumor-suppressor gene-related proteins in the myxom …
Protooncogene- and tumor-suppressor gene proteins serve essential functions in the regulation of proliferation and diff …
Tumor-suppressor gene products in cell contacts: the cadherin-APC-armadillo connection.
Hülsken J, Behrens J, Birchmeier W. Hülsken J, et al. Curr Opin Cell Biol. 1994 Oct;6(5):711-6. doi: 10.1016/0955-0674(94)90098-1. Curr Opin Cell Biol. 1994. PMID: 7833051 Review.
Various structural components of intercellular junctions have recently been found to represent (or be related to) products of tumor-suppressor genes. The tumor-suppressor gene product adenomatous polyposis coli (APC) binds t …
Various structural components of intercellular junctions have recently been found to represent (or be related to) products of tumo …
p53 tumor-suppressor gene: clues to molecular carcinogenesis.
Wang XW, Harris CC. Wang XW, et al. J Cell Physiol. 1997 Nov;173(2):247-55. doi: 10.1002/(SICI)1097-4652(199711)173:2<247::AID-JCP30>3.0.CO;2-A. J Cell Physiol. 1997. PMID: 9365531 Review.
The tumor-suppressor gene product p53 is clearly a component in several biochemical pathways, including transcription, DNA repair, genomic stability, cell-cycle control and apoptosis, that are central to human carcinogenesis. ...Recent insight into the …
The tumor-suppressor gene product p53 is clearly a component in several biochemical pathways, including transcri …
The tumor suppressor gene RIZ in cancer gene therapy (review).
Canote R, Du Y, Carling T, Tian F, Peng Z, Huang S. Canote R, et al. Oncol Rep. 2002 Jan-Feb;9(1):57-60. Oncol Rep. 2002. PMID: 11748455 Review.
The introduction of those genes into cancer cells where gene function is compromised, can work to restore gene function and stop tumor progression. ...The gene is commonly inactivated in human cancers. Gene knock-out study has established …
The introduction of those genes into cancer cells where gene function is compromised, can work to restore gene function …
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