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Tumor lysate-loaded Bacterial Ghosts as a tool for optimized production of therapeutic dendritic cell-based cancer vaccines.
Dobrovolskienė N, Pašukonienė V, Darinskas A, Kraśko JA, Žilionytė K, Mlynska A, Gudlevičienė Ž, Mišeikytė-Kaubrienė E, Schijns V, Lubitz W, Kudela P, Strioga M. Dobrovolskienė N, et al. Vaccine. 2018 Jul 5;36(29):4171-4180. doi: 10.1016/j.vaccine.2018.06.016. Epub 2018 Jun 9. Vaccine. 2018. PMID: 29895501
Among various factors responsible for their modest clinical activity is the lack of universally applied, standardized protocols for the generation of clinical-grade DC vaccines, capable of inducing effective anti-tumor immune responses. We investigated Bacterial
Among various factors responsible for their modest clinical activity is the lack of universally applied, standardized protocols for the gene …
Oncolysate-loaded Escherichia coli bacterial ghosts enhance the stimulatory capacity of human dendritic cells.
Michalek J, Hezova R, Turanek-Knötigova P, Gabkova J, Strioga M, Lubitz W, Kudela P. Michalek J, et al. Cancer Immunol Immunother. 2017 Feb;66(2):149-159. doi: 10.1007/s00262-016-1932-4. Epub 2016 Nov 18. Cancer Immunol Immunother. 2017. PMID: 27864613
The natural adjuvant properties of bacterial ghosts (BGs) lie within the presence of intact pathogen-associated molecular patterns on their surface. ...The induced T cells efficiently recognized oncolysate-derived tumor-associated antigens expressed by cancer …
The natural adjuvant properties of bacterial ghosts (BGs) lie within the presence of intact pathogen-associated molecular patt …