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Anti-Saccharomyces cerevisiae antibodies are frequent in type 1 diabetes.
Sakly W, Mankaï A, Sakly N, Thabet Y, Achour A, Ghedira-Besbes L, Jeddi M, Ghedira I. Sakly W, et al. Endocr Pathol. 2010 Jun;21(2):108-14. doi: 10.1007/s12022-010-9118-7. Endocr Pathol. 2010. PMID: 20387011
Anti-Saccharomyces cerevisiae antibodies (ASCA) have been described in many autoimmune diseases in which there is an increased intestinal permeability. Also in type 1 diabetes (T1D), there is an increased intestinal permeability. Since no data a …
Anti-Saccharomyces cerevisiae antibodies (ASCA) have been described in many autoimmune diseases in which there is an increased …
Anti-Saccharomyces Cerevisiae as Unusual Antibody in Autoimmune Polyglandular Syndrome Type III: A Case Report.
Gorgel A, Cankaya C, Tecellioglu M. Gorgel A, et al. Endocr Metab Immune Disord Drug Targets. 2019;19(1):90-94. doi: 10.2174/1871530318666180817143536. Endocr Metab Immune Disord Drug Targets. 2019. PMID: 30117403
Backgraund and Objective: Anti-Saccharomyces Cerevisiae Antibodies (ASCA) that are considered to reflect immune response against increased intestinal permeability due to mucosal damage are among the serological markers of Crohn's Disease. METHODS: This microbial ser …
Backgraund and Objective: Anti-Saccharomyces Cerevisiae Antibodies (ASCA) that are considered to reflect immune response again …
Fungal β-glucan, a Dectin-1 ligand, promotes protection from type 1 diabetes by inducing regulatory innate immune response.
Karumuthil-Melethil S, Gudi R, Johnson BM, Perez N, Vasu C. Karumuthil-Melethil S, et al. J Immunol. 2014 Oct 1;193(7):3308-21. doi: 10.4049/jimmunol.1400186. Epub 2014 Aug 20. J Immunol. 2014. PMID: 25143443 Free PMC article.
In this study, we show that the β-glucan from Saccharomyces cerevisiae induces the expression of immune regulatory cytokines (IL-10, TGF-β1, and IL-2) and a tolerogenic enzyme (IDO) in bone marrow-derived dendritic cells as well as spleen cells. These properties can …
In this study, we show that the β-glucan from Saccharomyces cerevisiae induces the expression of immune regulatory cytokines ( …
Anti-Saccharomyces cerevisiae autoantibodies in autoimmune diseases: from bread baking to autoimmunity.
Rinaldi M, Perricone R, Blank M, Perricone C, Shoenfeld Y. Rinaldi M, et al. Clin Rev Allergy Immunol. 2013 Oct;45(2):152-61. doi: 10.1007/s12016-012-8344-9. Clin Rev Allergy Immunol. 2013. PMID: 23292495 Review.
Saccharomyces cerevisiae is best known as the baker's and brewer's yeast, but its residual traces are also frequent excipients in some vaccines. Although anti-S. cerevisiae autoantibodies (ASCAs) are considered specific for Crohn's disease, a growing number o …
Saccharomyces cerevisiae is best known as the baker's and brewer's yeast, but its residual traces are also frequent excipients …
Genetic association analyses of atopic illness and proinflammatory cytokine genes with type 1 diabetes.
Saleh NM, Raj SM, Smyth DJ, Wallace C, Howson JM, Bell L, Walker NM, Stevens HE, Todd JA. Saleh NM, et al. Diabetes Metab Res Rev. 2011 Nov;27(8):838-43. doi: 10.1002/dmrr.1259. Diabetes Metab Res Rev. 2011. PMID: 22069270 Free PMC article.
BACKGROUND: The genetic basis of the autoimmune disease type 1 diabetes (T1D) has now been largely determined, so now we can compare these findings with emerging genetic knowledge of disorders and phenotypes that have been negatively or positively associated …
BACKGROUND: The genetic basis of the autoimmune disease type 1 diabetes (T1D) has now been largely determined, so now w …
The uncommon strong inhibition of α-glucosidase by multivalent glycoclusters based on cyclodextrin scaffolds.
Alali U, Vallin A, Bil A, Khanchouche T, Mathiron D, Przybylski C, Beaulieu R, Kovensky J, Benazza M, Bonnet V. Alali U, et al. Org Biomol Chem. 2019 Aug 14;17(30):7228-7237. doi: 10.1039/c9ob01344j. Epub 2019 Jul 17. Org Biomol Chem. 2019. PMID: 31313800
The homeostasis disruption of d-glucose causes diabetes, a dramatic chronic disease worldwide. Type 1 diabetes is a successfully treatable form, where blood d-glucose is regulated by insulin treatment. ...The results showed inhibition of α-glucosidase …
The homeostasis disruption of d-glucose causes diabetes, a dramatic chronic disease worldwide. Type 1 diabetes i …
Fungal Dysbiosis and Intestinal Inflammation in Children With Beta-Cell Autoimmunity.
Honkanen J, Vuorela A, Muthas D, Orivuori L, Luopajärvi K, Tejesvi MVG, Lavrinienko A, Pirttilä AM, Fogarty CL, Härkönen T, Ilonen J, Ruohtula T, Knip M, Koskimäki JJ, Vaarala O. Honkanen J, et al. Front Immunol. 2020 Mar 19;11:468. doi: 10.3389/fimmu.2020.00468. eCollection 2020. Front Immunol. 2020. PMID: 32265922 Free PMC article.
Although gut bacterial dysbiosis is recognized as a regulator of beta-cell autoimmunity, no data is available on fungal dysbiosis in the children at the risk of type 1 diabetes (T1D). ...Anti-Saccharomyces cerevisiae antibodies (ASCA) and circul …
Although gut bacterial dysbiosis is recognized as a regulator of beta-cell autoimmunity, no data is available on fungal dysbiosis in the chi …
Polymorphonuclear neutrophil dysfunctions in streptozotocin-induced type 1 diabetic rats.
Nabi AH, Islam LN, Rahman MM, Biswas KB. Nabi AH, et al. J Biochem Mol Biol. 2005 Nov 30;38(6):661-7. doi: 10.5483/bmbrep.2005.38.6.661. J Biochem Mol Biol. 2005. PMID: 16336780
Since conflicting results have been reported on non-specific immune response in type 1 diabetes, this study evaluates polymorphonuclear neutrophil (PMN) functions in the infection free Long Evan diabetic rats (type 1) by using tests that include …
Since conflicting results have been reported on non-specific immune response in type 1 diabetes, this study evaluates p …
Expression in Saccharomyces cerevisiae of antigenically and enzymatically active recombinant glutamic acid decarboxylase.
Law RH, Rowley MJ, Mackay IR, Corner B. Law RH, et al. J Biotechnol. 1998 Mar 26;61(1):57-68. doi: 10.1016/s0168-1656(98)00013-3. J Biotechnol. 1998. PMID: 9650286
Glutamic acid decarboxylase (GAD) is one of the major autoantigens found in insulin-dependent (Type 1) diabetes mellitus (IDDM). ...This hybrid GAD67/65 was expressed constitutively under the control of the phosphoglycerate kinase promoter (PGK1) in th …
Glutamic acid decarboxylase (GAD) is one of the major autoantigens found in insulin-dependent (Type 1) diabetes mell …
Comparative expression and purification of human glutamic acid decarboxylase from Saccharomyces cerevisiae and Pichia pastoris.
Papakonstantinou T, Law RH, Gardiner P, Rowley MJ, Mackay IR. Papakonstantinou T, et al. Enzyme Microb Technol. 2000 Jun 1;26(9-10):645-652. doi: 10.1016/s0141-0229(00)00154-x. Enzyme Microb Technol. 2000. PMID: 10862868
They include glutamic acid decarboxylase (GAD), which is one of the major autoantigens for Type 1 diabetes. We have created a hybrid form of GAD consisting of amino acids 1-101 of the human GAD67 protein fused to amino acids 96-585 of the human GAD65 p …
They include glutamic acid decarboxylase (GAD), which is one of the major autoantigens for Type 1 diabetes. We have cre …
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