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Women with type 1 diabetes exhibit a progressive increase in gut Saccharomyces cerevisiae in pregnancy associated with evidence of gut inflammation.
Bandala-Sanchez E, Roth-Schulze AJ, Oakey H, Penno MAS, Bediaga NG, Naselli G, Ngui KM, Smith AD, Huang D, Zozaya-Valdes E, Thomson RL, Brown JD, Vuillermin PJ, Barry SC, Craig ME, Rawlinson WD, Davis EA, Harris M, Soldatos G, Colman PG, Wentworth JM, Haynes A, Morahan G, Sinnott RO, Papenfuss AT, Couper JJ, Harrison LC; ENDIA Study Group. Bandala-Sanchez E, et al. Diabetes Res Clin Pract. 2022 Feb;184:109189. doi: 10.1016/j.diabres.2022.109189. Epub 2022 Jan 18. Diabetes Res Clin Pract. 2022. PMID: 35051423 Free article.
We aimed to characterize the gut fungal microbiome (mycobiome) across pregnancy in women with and without type 1 diabetes. METHODS: Faecal samples (n = 162) were collected from 70 pregnant women (45 with and 25 without type 1 diabetes) ac …
We aimed to characterize the gut fungal microbiome (mycobiome) across pregnancy in women with and without type 1 diabetes …
Anti-Saccharomyces cerevisiae antibodies are frequent in type 1 diabetes.
Sakly W, Mankaï A, Sakly N, Thabet Y, Achour A, Ghedira-Besbes L, Jeddi M, Ghedira I. Sakly W, et al. Endocr Pathol. 2010 Jun;21(2):108-14. doi: 10.1007/s12022-010-9118-7. Endocr Pathol. 2010. PMID: 20387011
Anti-Saccharomyces cerevisiae antibodies (ASCA) have been described in many autoimmune diseases in which there is an increased intestinal permeability. Also in type 1 diabetes (T1D), there is an increased intestinal permeability. ...
Anti-Saccharomyces cerevisiae antibodies (ASCA) have been described in many autoimmune diseases in which there is an increased …
Confirmation and Identification of Biomarkers Implicating Environmental Triggers in the Pathogenesis of Type 1 Diabetes.
Harms RZ, Ostlund KR, Cabrera MS, Edwards E, Fisher M, Sarvetnick N. Harms RZ, et al. Front Immunol. 2020 Sep 15;11:1922. doi: 10.3389/fimmu.2020.01922. eCollection 2020. Front Immunol. 2020. PMID: 33042112 Free PMC article.
Multiple environmental triggers have been proposed to explain the increased incidence of type 1 diabetes (T1D). These include viral infections, microbiome disturbances, metabolic disorders, and vitamin D deficiency. ...Subjects also were tested for prevalence …
Multiple environmental triggers have been proposed to explain the increased incidence of type 1 diabetes (T1D). These i …
Anti-Saccharomyces cerevisiae autoantibodies in autoimmune diseases: from bread baking to autoimmunity.
Rinaldi M, Perricone R, Blank M, Perricone C, Shoenfeld Y. Rinaldi M, et al. Clin Rev Allergy Immunol. 2013 Oct;45(2):152-61. doi: 10.1007/s12016-012-8344-9. Clin Rev Allergy Immunol. 2013. PMID: 23292495 Review.
Saccharomyces cerevisiae is best known as the baker's and brewer's yeast, but its residual traces are also frequent excipients in some vaccines. Although anti-S. cerevisiae autoantibodies (ASCAs) are considered specific for Crohn's disease, a growing number o …
Saccharomyces cerevisiae is best known as the baker's and brewer's yeast, but its residual traces are also frequent excipients …
Anti-Saccharomyces Cerevisiae as Unusual Antibody in Autoimmune Polyglandular Syndrome Type III: A Case Report.
Gorgel A, Cankaya C, Tecellioglu M. Gorgel A, et al. Endocr Metab Immune Disord Drug Targets. 2019;19(1):90-94. doi: 10.2174/1871530318666180817143536. Endocr Metab Immune Disord Drug Targets. 2019. PMID: 30117403
Backgraund and Objective: Anti-Saccharomyces Cerevisiae Antibodies (ASCA) that are considered to reflect immune response against increased intestinal permeability due to mucosal damage are among the serological markers of Crohn's Disease. METHODS: This microbial ser …
Backgraund and Objective: Anti-Saccharomyces Cerevisiae Antibodies (ASCA) that are considered to reflect immune response again …
Fungal Dysbiosis and Intestinal Inflammation in Children With Beta-Cell Autoimmunity.
Honkanen J, Vuorela A, Muthas D, Orivuori L, Luopajärvi K, Tejesvi MVG, Lavrinienko A, Pirttilä AM, Fogarty CL, Härkönen T, Ilonen J, Ruohtula T, Knip M, Koskimäki JJ, Vaarala O. Honkanen J, et al. Front Immunol. 2020 Mar 19;11:468. doi: 10.3389/fimmu.2020.00468. eCollection 2020. Front Immunol. 2020. PMID: 32265922 Free PMC article.
Although gut bacterial dysbiosis is recognized as a regulator of beta-cell autoimmunity, no data is available on fungal dysbiosis in the children at the risk of type 1 diabetes (T1D). We hypothesized that the co-occurrence of fungal and bacterial dysbiosis co …
Although gut bacterial dysbiosis is recognized as a regulator of beta-cell autoimmunity, no data is available on fungal dysbiosis in the chi …
Fungal β-glucan, a Dectin-1 ligand, promotes protection from type 1 diabetes by inducing regulatory innate immune response.
Karumuthil-Melethil S, Gudi R, Johnson BM, Perez N, Vasu C. Karumuthil-Melethil S, et al. J Immunol. 2014 Oct 1;193(7):3308-21. doi: 10.4049/jimmunol.1400186. Epub 2014 Aug 20. J Immunol. 2014. PMID: 25143443 Free PMC article.
In this study, we show that the beta-glucan from Saccharomyces cerevisiae induces the expression of immune regulatory cytokines (IL-10, TGF-beta1, and IL-2) and a tolerogenic enzyme (IDO) in bone marrow-derived dendritic cells as well as spleen cells. These properti …
In this study, we show that the beta-glucan from Saccharomyces cerevisiae induces the expression of immune regulatory cytokine …
Genetic association analyses of atopic illness and proinflammatory cytokine genes with type 1 diabetes.
Saleh NM, Raj SM, Smyth DJ, Wallace C, Howson JM, Bell L, Walker NM, Stevens HE, Todd JA. Saleh NM, et al. Diabetes Metab Res Rev. 2011 Nov;27(8):838-43. doi: 10.1002/dmrr.1259. Diabetes Metab Res Rev. 2011. PMID: 22069270 Free PMC article.
BACKGROUND: The genetic basis of the autoimmune disease type 1 diabetes (T1D) has now been largely determined, so now we can compare these findings with emerging genetic knowledge of disorders and phenotypes that have been negatively or positively associated …
BACKGROUND: The genetic basis of the autoimmune disease type 1 diabetes (T1D) has now been largely determined, so now w …
Bioinspired oral insulin delivery system using yeast microcapsules.
Sabu C, Raghav D, Jijith US, Mufeedha P, Naseef PP, Rathinasamy K, Pramod K. Sabu C, et al. Mater Sci Eng C Mater Biol Appl. 2019 Oct;103:109753. doi: 10.1016/j.msec.2019.109753. Epub 2019 May 23. Mater Sci Eng C Mater Biol Appl. 2019. PMID: 31349477
Type 1 diabetes mellitus (DM) is a metabolic disorder associated with impaired carbohydrate metabolism. We present a promising bioinspired approach against type 1 DM using yeast microcapsule (YMC). The glucan component in the outer shell …
Type 1 diabetes mellitus (DM) is a metabolic disorder associated with impaired carbohydrate metabolism. We prese …
The uncommon strong inhibition of α-glucosidase by multivalent glycoclusters based on cyclodextrin scaffolds.
Alali U, Vallin A, Bil A, Khanchouche T, Mathiron D, Przybylski C, Beaulieu R, Kovensky J, Benazza M, Bonnet V. Alali U, et al. Org Biomol Chem. 2019 Aug 14;17(30):7228-7237. doi: 10.1039/c9ob01344j. Epub 2019 Jul 17. Org Biomol Chem. 2019. PMID: 31313800
The homeostasis disruption of d-glucose causes diabetes, a dramatic chronic disease worldwide. Type 1 diabetes is a successfully treatable form, where blood d-glucose is regulated by insulin treatment. In contrast type 2 diabetes, the non …
The homeostasis disruption of d-glucose causes diabetes, a dramatic chronic disease worldwide. Type 1 diabetes i …
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