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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1982 1
1983 1
1985 2
1986 3
1988 4
1989 3
1990 3
1991 5
1992 4
1994 3
1995 6
1997 3
1998 1
1999 2
2000 1
2001 2
2002 4
2003 2
2004 2
2005 5
2006 3
2007 1
2008 1
2009 5
2010 5
2011 2
2012 5
2013 4
2014 3
2015 2
2016 5
2017 4
2018 3
2019 2
2020 1
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Page 1
Transcription factors operate across disease loci, with EBNA2 implicated in autoimmunity.
Harley JB, Chen X, Pujato M, Miller D, Maddox A, Forney C, Magnusen AF, Lynch A, Chetal K, Yukawa M, Barski A, Salomonis N, Kaufman KM, Kottyan LC, Weirauch MT. Harley JB, et al. Nat Genet. 2018 May;50(5):699-707. doi: 10.1038/s41588-018-0102-3. Epub 2018 Apr 16. Nat Genet. 2018. PMID: 29662164 Free PMC article.
Strikingly, nearly half of systemic lupus erythematosus risk loci are occupied by the Epstein-Barr virus EBNA2 protein and many coclustering human TFs, showing gene-environment interaction. Similar EBNA2-anchored associations exist in multiple sclerosis, rheumatoid …
Strikingly, nearly half of systemic lupus erythematosus risk loci are occupied by the Epstein-Barr virus EBNA2 protein and man …
Effects of Type 1 Diabetes Risk Alleles on Immune Cell Gene Expression.
Ram R, Morahan G. Ram R, et al. Genes (Basel). 2017 Jun 21;8(6):167. doi: 10.3390/genes8060167. Genes (Basel). 2017. PMID: 28635624 Free PMC article. Review.
Genetic studies have identified 61 variants associated with the risk of developing Type 1 Diabetes (T1D). The functions of most of the non-HLA (Human Leukocyte Antigen) genetic variants remain unknown. ...To do so, we examined whole transcriptome profiles of …
Genetic studies have identified 61 variants associated with the risk of developing Type 1 Diabetes (T1D). The functions …
Seasonality and autoimmune diseases: The contribution of the four seasons to the mosaic of autoimmunity.
Watad A, Azrielant S, Bragazzi NL, Sharif K, David P, Katz I, Aljadeff G, Quaresma M, Tanay G, Adawi M, Amital H, Shoenfeld Y. Watad A, et al. J Autoimmun. 2017 Aug;82:13-30. doi: 10.1016/j.jaut.2017.06.001. Epub 2017 Jun 16. J Autoimmun. 2017. PMID: 28624334 Review.
During the winter, increased incidence of Epstein-Barr virus (EBV) infectious are associated with MS and SLE flares/onset respectively. In addition, higher Rotavirus infections during the winter precedes type 1 diabetes mellitus onset (T1 …
During the winter, increased incidence of Epstein-Barr virus (EBV) infectious are associated with MS and SLE flares/onset resp …
Normal suppressive T cell function of Epstein-Barr virus induced B cell activation in type 1 (insulin dependent) diabetes mellitus.
Kahan A, LeFloch JP, Charreire J. Kahan A, et al. Autoimmunity. 1990;5(4):257-64. doi: 10.3109/08916939009014710. Autoimmunity. 1990. PMID: 1966582
To investigate whether this abnormality is a common feature to other autoimmune diseases, we studied T cell regulation of Epstein-Barr virus induced B cell activation in 15 newly diagnosed type 1 (insulin dependent) diabetes mellitus pati …
To investigate whether this abnormality is a common feature to other autoimmune diseases, we studied T cell regulation of Epstein- …
Low-dose otelixizumab anti-CD3 monoclonal antibody DEFEND-1 study: results of the randomized phase III study in recent-onset human type 1 diabetes.
Aronson R, Gottlieb PA, Christiansen JS, Donner TW, Bosi E, Bode BW, Pozzilli P; DEFEND Investigator Group. Aronson R, et al. Diabetes Care. 2014 Oct;37(10):2746-54. doi: 10.2337/dc13-0327. Epub 2014 Jul 10. Diabetes Care. 2014. PMID: 25011949 Free PMC article. Clinical Trial.
OBJECTIVE: Previous studies demonstrated that the anti-CD3 monoclonal antibody otelixizumab, administered at a total dose of 48-64 mg, can slow the loss of C-peptide in recent-onset type 1 diabetes patients, with frequent reactivation of Epstein Bar …
OBJECTIVE: Previous studies demonstrated that the anti-CD3 monoclonal antibody otelixizumab, administered at a total dose of 48-64 mg, can s …
Fulminant type 1 diabetes mellitus associated with a reactivation of Epstein-Barr virus that developed in the course of chemotherapy of multiple myeloma.
Fujiya A, Ochiai H, Mizukoshi T, Kiyota A, Shibata T, Suzuki A, Ohashi N, Sobajima H. Fujiya A, et al. J Diabetes Investig. 2010 Dec 3;1(6):286-9. doi: 10.1111/j.2040-1124.2010.00061.x. J Diabetes Investig. 2010. PMID: 24843446 Free PMC article.
Her elevated Epstein-Barr virus (EBV) antibody levels showed that the hepatopathy was caused by reactivation of EBV. On the 18th hospital day, the levels of fasting plasma glucose (FPG; 451 mg/dL) and pancreatic enzymes were suddenly elevated. ...These features were …
Her elevated Epstein-Barr virus (EBV) antibody levels showed that the hepatopathy was caused by reactivation of EBV. On the 18 …
Type 1 diabetes associated and tissue transglutaminase autoantibodies in patients without type 1 diabetes and coeliac disease with confirmed viral infections.
Sarmiento L, Galvan JA, Cabrera-Rode E, Aira L, Correa C, Sariego S, Fonseca M, Cubas-Dueñas I, Hung LH, Resik S, Cilio CM. Sarmiento L, et al. J Med Virol. 2012 Jul;84(7):1049-53. doi: 10.1002/jmv.23305. J Med Virol. 2012. PMID: 22585721
Coeliac disease and type 1 diabetes are autoimmune diseases that may share the same initiating environmental factors. In this study, the occurrence of type 1 diabetes associated autoantibodies (GADA and IA-2A) and tissue transglutaminase …
Coeliac disease and type 1 diabetes are autoimmune diseases that may share the same initiating environmental factors. I …
Relating homology between the Epstein-Barr virus BOLF1 molecule and HLA-DQw8 beta chain to recent onset type 1 (insulin-dependent) diabetes mellitus.
Sairenji T, Daibata M, Sorli CH, Qvistbäck H, Humphreys RE, Ludvigsson J, Palmer J, Landin-Olsson M, Sundkvist G, Michelsen B, et al. Sairenji T, et al. Diabetologia. 1991 Jan;34(1):33-9. doi: 10.1007/BF00404022. Diabetologia. 1991. PMID: 1647336
A role for the Epstein-Barr virus in initiating Type 1 (insulin-dependent) diabetes mellitus has been proposed since Epstein-Barr virus BOLF1 (497-513) AVTPL RIFIVPPAAEY has an 11 amino acid identity with HLA-DQw8 beta (49-6 …
A role for the Epstein-Barr virus in initiating Type 1 (insulin-dependent) diabetes mellitus has b …
A new look at viruses in type 1 diabetes.
Jun HS, Yoon JW. Jun HS, et al. Diabetes Metab Res Rev. 2003 Jan-Feb;19(1):8-31. doi: 10.1002/dmrr.337. Diabetes Metab Res Rev. 2003. PMID: 12592641 Review.
Type 1 diabetes (T1D) results from the destruction of pancreatic beta cells. Genetic factors are believed to be a major component for the development of T1D, but the concordance rate for the development of diabetes in identical twins is only about 40%, …
Type 1 diabetes (T1D) results from the destruction of pancreatic beta cells. Genetic factors are believed to be a major …
Epstein-Barr and other herpesvirus infections in patients with early onset type 1 diabetes treated with daclizumab and mycophenolate mofetil.
Loechelt BJ, Boulware D, Green M, Baden LR, Gottlieb P, Krause-Steinrauf H, Weinberg A; Type 1 Diabetes TrialNet Daclizumab/Mycophenolic Acid Study Group. Loechelt BJ, et al. Clin Infect Dis. 2013 Jan;56(2):248-54. doi: 10.1093/cid/cis848. Epub 2012 Oct 5. Clin Infect Dis. 2013. PMID: 23042974 Free PMC article.
BACKGROUND: We assessed the morbidity of herpesviruses in patients with type 1 diabetes mellitus (T1D) enrolled in immunosuppressive treatment studies. METHODS: Epstein-Barr virus (EBV), cytomegalovirus (CMV), herpes simplex virus (HSV), …
BACKGROUND: We assessed the morbidity of herpesviruses in patients with type 1 diabetes mellitus (T1D) enrolled …
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