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Association of human endogenous retrovirus K-18 polymorphisms with type 1 diabetes.
Marguerat S, Wang WY, Todd JA, Conrad B. Marguerat S, et al. Diabetes. 2004 Mar;53(3):852-4. doi: 10.2337/diabetes.53.3.852. Diabetes. 2004. PMID: 14988274
Several lines of evidence suggest the involvement of the human endogenous retrovirus (HERV)-K18 in the etiology of type 1 diabetes. ...
Several lines of evidence suggest the involvement of the human endogenous retrovirus (HERV)-K18 in the etiology of t
Enhanced expression of human endogenous retroviruses in new-onset type 1 diabetes: Potential pathogenetic and therapeutic implications.
Tovo PA, Rabbone I, Tinti D, Galliano I, Trada M, Daprà V, Cerutti F, Bergallo M. Tovo PA, et al. Autoimmunity. 2020 Aug;53(5):283-288. doi: 10.1080/08916934.2020.1777281. Epub 2020 Jun 25. Autoimmunity. 2020. PMID: 32586158
Human endogenous retroviruses (HERVs) have been studied and proposed as relevant cofactors in several autoimmune diseases, including type 1 diabetes (T1D), though with controversial results and no study at disease onset. In order to gathe
Human endogenous retroviruses (HERVs) have been studied and proposed as relevant cofactors in several autoimmune diseas
Low HERV-K(C4) copy number is associated with type 1 diabetes.
Mason MJ, Speake C, Gersuk VH, Nguyen QA, O'Brien KK, Odegard JM, Buckner JH, Greenbaum CJ, Chaussabel D, Nepom GT. Mason MJ, et al. Diabetes. 2014 May;63(5):1789-95. doi: 10.2337/db13-1382. Epub 2014 Jan 15. Diabetes. 2014. PMID: 24430436
We investigated the relationship between C4 variation/CN and type 1 diabetes. We found that individuals with type 1 diabetes have significantly fewer copies of HERV-K(C4) and that this effect is not solely due to linkage with known …
We investigated the relationship between C4 variation/CN and type 1 diabetes. We found that individuals with type
Human endogenous retrovirus with a high genomic sequence homology with IDDMK(1,2)22 is not specific for Type I (insulin-dependent) diabetic patients but ubiquitous.
Kim A, Jun HS, Wong L, Stephure D, Pacaud D, Trussell RA, Yoon JW. Kim A, et al. Diabetologia. 1999 Apr;42(4):413-8. doi: 10.1007/s001250051173. Diabetologia. 1999. PMID: 10230644
AIMS/HYPOTHESIS: It has been reported recently that a novel human endogenous retroviral gene, insulin-dependent diabetes mellitus (IDDM)K(1,2)22, was expressed in the plasma of Type I diabetic patients but not in that of nondiabetic control subjects. ...CONCL …
AIMS/HYPOTHESIS: It has been reported recently that a novel human endogenous retroviral gene, insulin-dependent diabetes melli …
The presence or absence of a retroviral long terminal repeat influences the genetic risk for type 1 diabetes conferred by human leukocyte antigen DQ haplotypes. Belgian Diabetes Registry.
Donner H, Tönjes RR, Van der Auwera B, Siegmund T, Braun J, Weets I, Herwig J, Kurth R, Usadel KH, Badenhoop K. Donner H, et al. J Clin Endocrinol Metab. 1999 Apr;84(4):1404-8. doi: 10.1210/jcem.84.4.5638. J Clin Endocrinol Metab. 1999. PMID: 10199786
Major genetic susceptibility to type 1 diabetes mellitus maps to the human leukocyte antigen (HLA) region on chromosome 6p. ...We analyzed the presence of a solitary HERV-K LTR in the HLA DQ region (DQ-LTR3) and its linkage to DRB1, DQA1, …
Major genetic susceptibility to type 1 diabetes mellitus maps to the human leukocyte antigen (HLA) region …
The variable endogenous retroviral insertion in the human complement C4 gene: a transmission study in type I diabetes mellitus.
Pani MA, Wood JP, Bieda K, Toenjes RR, Usadel KH, Badenhoop K. Pani MA, et al. Hum Immunol. 2002 Jun;63(6):481-4. doi: 10.1016/s0198-8859(02)00398-1. Hum Immunol. 2002. PMID: 12039523
A variable endogenous retroviral element has been identified in intron 9 of the complement C4 gene [HERV-K(C4)], which maps to the class III region of the major histocompatibility complex (MHC) on chromosome 6p21.3. ...There was no preferential transmission of the H …
A variable endogenous retroviral element has been identified in intron 9 of the complement C4 gene [HERV-K(C4)], which maps to …
The studies on human endogenous retrovirus gene expression, distribution of the genome and association with IDDM and other inheritance- related diseases.
Liang HC. Liang HC. Zhonghua Shi Yan He Lin Chuang Bing Du Xue Za Zhi. 2000 Jun;14(2):105-8. Zhonghua Shi Yan He Lin Chuang Bing Du Xue Za Zhi. 2000. PMID: 11503035
OBJECTIVE: The mechanism for type 1 diabetes still remains unclear. This study was focused on the viral morphology, endogenous retrovirus expression, immunology and molecular biology. ...Human endogenous retroviral pol gene express …
OBJECTIVE: The mechanism for type 1 diabetes still remains unclear. This study was focused on the viral morphology, …
HERV-K Envelope Protein Induces Long-Lasting Production of Autoantibodies in T1DM Patients at Onset in Comparison to ZNT8 Autoantibodies.
Noli M, Meloni G, Ruberto S, Jasemi S, Simula ER, Cossu D, Bo M, Palermo M, Sechi LA. Noli M, et al. Pathogens. 2022 Oct 15;11(10):1188. doi: 10.3390/pathogens11101188. Pathogens. 2022. PMID: 36297245 Free PMC article.
Human endogenous retroviruses (HERVs) have been thought of as silent passengers within our genomes, but their reactivation has been linked with several autoimmune diseases, including type 1 diabetes (T1DM). ...Our results add new evidence
Human endogenous retroviruses (HERVs) have been thought of as silent passengers within our genomes, but their reactivat
Identification of a novel HERV-K(HML10): comprehensive characterization and comparative analysis in non-human primates provide insights about HML10 proviruses structure and diffusion.
Grandi N, Cadeddu M, Pisano MP, Esposito F, Blomberg J, Tramontano E. Grandi N, et al. Mob DNA. 2017 Nov 2;8:15. doi: 10.1186/s13100-017-0099-7. eCollection 2017. Mob DNA. 2017. PMID: 29118853 Free PMC article.
BACKGROUND: About half of the human genome is constituted of transposable elements, including human endogenous retroviruses (HERV). ...In particular, the HML10 group was reported to be upregulated in persistent HIV-1 infected cells as well as in tumor …
BACKGROUND: About half of the human genome is constituted of transposable elements, including human endogenous retro
14 results