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Do microbes have a causal role in type 1 diabetes?
Lammi N, Karvonen M, Tuomilehto J. Lammi N, et al. Med Sci Monit. 2005 Mar;11(3):RA63-9. Med Sci Monit. 2005. PMID: 15735577 Review.
Type 1 diabetes mellitus (T1DM) results from environmental factors acting on genetically susceptible individuals. ...A newly emerged hypothesis states that a bacterial toxin, bafilomycin A1 produced by Streptomyces spp, could be the cause of pan
Type 1 diabetes mellitus (T1DM) results from environmental factors acting on genetically susceptible individuals
Dietary microbial toxins and type 1 diabetes.
Myers MA, Hettiarachchi KD, Ludeman JP, Wilson AJ, Wilson CR, Zimmet PZ. Myers MA, et al. Ann N Y Acad Sci. 2003 Nov;1005:418-22. doi: 10.1196/annals.1288.071. Ann N Y Acad Sci. 2003. PMID: 14679104
Toxins may promote type 1 diabetes by modifying or damaging the beta cell causing release of autoantigens. ...Thus, exposure to small quantities of bafilomycin in the diet may contribute to the cause of type 1 diabetes....
Toxins may promote type 1 diabetes by modifying or damaging the beta cell causing release of autoantigens. ...Thus, exp …
Dietary toxins, endoplasmic reticulum (ER) stress and diabetes.
Hettiarachchi KD, Zimmet PZ, Myers MA. Hettiarachchi KD, et al. Curr Diabetes Rev. 2008 May;4(2):146-56. doi: 10.2174/157339908784220697. Curr Diabetes Rev. 2008. PMID: 18473761 Review.
The incidence of Type 1 diabetes has been increasing at a rate too rapid to be due to changes in genetic risk. ...Furthermore, we propose that the increasing incidence of Type 1 diabetes may be accounted for by increased dietary exposure …
The incidence of Type 1 diabetes has been increasing at a rate too rapid to be due to changes in genetic risk. ...Furth …
A green tea-triggered genetic control system for treating diabetes in mice and monkeys.
Yin J, Yang L, Mou L, Dong K, Jiang J, Xue S, Xu Y, Wang X, Lu Y, Ye H. Yin J, et al. Sci Transl Med. 2019 Oct 23;11(515):eaav8826. doi: 10.1126/scitranslmed.aav8826. Sci Transl Med. 2019. PMID: 31645456
We constructed multiple genetic control technologies that could toggle a PCA-responsive ON/OFF switch based on a transcriptional repressor from Streptomyces coelicolor We demonstrated that PCA-controlled switches can be used for guide RNA expression-mediated control of the …
We constructed multiple genetic control technologies that could toggle a PCA-responsive ON/OFF switch based on a transcriptional repressor f …
Transplacental exposure to bafilomycin disrupts pancreatic islet organogenesis and accelerates diabetes onset in NOD mice.
Hettiarachchi KD, Zimmet PZ, Myers MA. Hettiarachchi KD, et al. J Autoimmun. 2004 Jun;22(4):287-96. doi: 10.1016/j.jaut.2004.02.004. J Autoimmun. 2004. PMID: 15120752
We therefore determined whether dietary bafilomycin influenced the progression of diabetes in the non-obese diabetic (NOD) mouse model of autoimmune Type 1 diabetes. ...Since bafilomycin and related plecomacrolides contaminate Streptomyces-infec …
We therefore determined whether dietary bafilomycin influenced the progression of diabetes in the non-obese diabetic (NOD) mouse mode …
Effect of FK506 on the development of diabetes in BB rats in comparison with that of cyclosporin.
Wakugami T, Islam MR, Higa S, Murakami K, Mimura G. Wakugami T, et al. Tohoku J Exp Med. 1993 Jan;169(1):21-9. doi: 10.1620/tjem.169.21. Tohoku J Exp Med. 1993. PMID: 7692621 Free article.
We compared the preventive effect of FK506 on the development of diabetes mellitus with that of cyclosporin in BB rats, which are regarded as a useful model of insulin-dependent diabetes mellitus. ...Diabetes developed in 2 (10.5%) of 19 rats tr …
We compared the preventive effect of FK506 on the development of diabetes mellitus with that of cyclosporin in BB rats, which …
The immunosuppressant FK-506 prevents progression of diabetes in nonobese diabetic mice.
Kurasawa K, Koike T, Matsumura R, Takabayashi K, Tomioka H, Ito I, Yoshida S. Kurasawa K, et al. Clin Immunol Immunopathol. 1990 Nov;57(2):274-9. doi: 10.1016/0090-1229(90)90041-n. Clin Immunol Immunopathol. 1990. PMID: 1698584
A novel immunosuppressive compound, FK-506, isolated from Streptomyces has potent immunosuppressive activities. To investigate the effect of FK-506 on the course of diabetes in nonobese diabetic (NOD) mice, we gave this drug to these animals, from the age of 8 weeks …
A novel immunosuppressive compound, FK-506, isolated from Streptomyces has potent immunosuppressive activities. To investigate the ef …
Differential presentation of glutamic acid decarboxylase 65 (GAD65) T cell epitopes among HLA-DRB1*0401-positive individuals.
Reijonen H, Elliott JF, van Endert P, Nepom G. Reijonen H, et al. J Immunol. 1999 Aug 1;163(3):1674-81. J Immunol. 1999. PMID: 10415074
Glutamic acid decarboxylase 65 (GAD65) is one of the major autoantigens in type 1 diabetes. We investigated whether there is variation in the processing of GAD65 epitopes between individuals with similar HLA backgrounds and whether the processing characterist …
Glutamic acid decarboxylase 65 (GAD65) is one of the major autoantigens in type 1 diabetes. We investigated whether the …
Diabetic BB/Wor rat haptoglobin exhibits a probable structural abnormality in Asn-linked oligosaccharides.
Chapman AE, Copeland P, Davidson S, Calhoun JC 4th. Chapman AE, et al. Biochim Biophys Acta. 1991 Apr 29;1077(3):265-72. doi: 10.1016/0167-4838(91)90539-c. Biochim Biophys Acta. 1991. PMID: 2029525
Haptoglobin from both normal and diabetic rats was resistant to digestion by endoglycosidase H from Streptomyces griseus, which cleaves high mannose-type chains. Removal of sialic acid with neuraminidase treatment resulted in a reduction in the molecular mass in bot …
Haptoglobin from both normal and diabetic rats was resistant to digestion by endoglycosidase H from Streptomyces griseus, which cleav …