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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1947 1
1958 1
1961 1
1962 1
1963 9
1964 10
1965 8
1966 10
1967 19
1968 24
1969 31
1970 44
1971 56
1972 61
1973 70
1974 65
1975 67
1976 47
1977 44
1978 40
1979 35
1980 38
1981 35
1982 47
1983 48
1984 50
1985 62
1986 72
1987 48
1988 75
1989 112
1990 112
1991 158
1992 224
1993 280
1994 330
1995 410
1996 453
1997 419
1998 482
1999 509
2000 487
2001 495
2002 500
2003 424
2004 480
2005 452
2006 446
2007 422
2008 447
2009 479
2010 493
2011 441
2012 518
2013 479
2014 481
2015 460
2016 447
2017 514
2018 457
2019 473
2020 497
2021 489
2022 351
2023 370
2024 433
2025 555
2026 334

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15,877 results

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p-Azobenzenearsonate-L-tyrosine-mediated helper function in immune responses of guinea pigs and rats.
Becker MJ, Ray A, Andersson LC, MAKELA O. Becker MJ, et al. Eur J Immunol. 1975 Apr;5(4):262-6. doi: 10.1002/eji.1830050409. Eur J Immunol. 1975. PMID: 1086231
A small bifunctional antigen (4-hydroxy-5-iodo-3-nitrophenyl)acetyl-epsilon-aminocaproyl-L-tyrosine-azobenzene-p-arsonate [NIP-cap-TYR(ABA)] was found to induce fair humoral antibody formation against NIP-cap but very little anti-ABA-TYR. ...
A small bifunctional antigen (4-hydroxy-5-iodo-3-nitrophenyl)acetyl-epsilon-aminocaproyl-L-tyrosine-azobenzene-p-arsonate [NIP-cap-TY …
Unperturbed Immune Function despite Mutation of C-Terminal Tyrosines in Syk Previously Implicated in Signaling and Activity Regulation.
Weis V, Königsberger S, Amler S, Wienands J, Kiefer F. Weis V, et al. Mol Cell Biol. 2017 Oct 13;37(21):e00216-17. doi: 10.1128/MCB.00216-17. Print 2017 Nov 1. Mol Cell Biol. 2017. PMID: 28760774 Free PMC article.
The nonreceptor tyrosine kinase Syk, a central regulator of immune cell differentiation and activation, is a promising drug target for treatment of leukemia and allergic and inflammatory diseases. The clinical failure of Syk inhibitors underscores the importance of …
The nonreceptor tyrosine kinase Syk, a central regulator of immune cell differentiation and activation, is a promising drug ta …
Non-canonical roles of Siglecs: Beyond sialic acid-binding and immune cell modulation.
Siddiqui SS. Siddiqui SS. Mol Aspects Med. 2023 Apr;90:101145. doi: 10.1016/j.mam.2022.101145. Epub 2022 Sep 22. Mol Aspects Med. 2023. PMID: 36153172 Review.
Most are expressed on the surface of leukocytes and are involved in immune regulation and possess immune tyrosine-based inhibitory motif (ITIM) in the intracellular domain, thus leading to inhibition of the immune response. ...By contrast, activating S …
Most are expressed on the surface of leukocytes and are involved in immune regulation and possess immune tyrosine-based …
Importance of tyrosine phosphorylation for transmembrane signaling in plants.
Mühlenbeck H, Bender KW, Zipfel C. Mühlenbeck H, et al. Biochem J. 2021 Jul 30;478(14):2759-2774. doi: 10.1042/BCJ20210202. Biochem J. 2021. PMID: 34297043 Free PMC article. Review.
Reversible protein phosphorylation is a widespread post-translational modification fundamental for signaling across all domains of life. Tyrosine (Tyr) phosphorylation has recently emerged as being important for plant receptor kinase (RK)-mediated signaling, particularly d …
Reversible protein phosphorylation is a widespread post-translational modification fundamental for signaling across all domains of life. …
Advancements in tyrosine kinase-mediated regulation of innate nucleic acid sensing.
Liu S, Xu P. Liu S, et al. Zhejiang Da Xue Xue Bao Yi Xue Ban. 2024 Jan 19;53(1):35-46. doi: 10.3724/zdxbyxb-2023-0480. Zhejiang Da Xue Xue Bao Yi Xue Ban. 2024. PMID: 38426691 Free PMC article. Review. Chinese, English.
This review summarizes the recent advances in research on tyrosine kinases and tyrosine phosphorylation in regulation of nucleic acid sensing. The function and potential applications of targeting tyrosine phosphorylation in anti-tumor immunity is disus …
This review summarizes the recent advances in research on tyrosine kinases and tyrosine phosphorylation in regulation of nucle …
Inhibitory ITAMs as novel regulators of immunity.
Blank U, Launay P, Benhamou M, Monteiro RC. Blank U, et al. Immunol Rev. 2009 Nov;232(1):59-71. doi: 10.1111/j.1600-065X.2009.00832.x. Immunol Rev. 2009. PMID: 19909356 Review.
Immune responses involve the activation of immunoreceptors that contain tyrosine-based activation motifs (ITAMs). ...ITAMi signaling is also exploited by Escherichia coli to achieve immune evasion during sepsis. Here, we review our current understanding of IT …
Immune responses involve the activation of immunoreceptors that contain tyrosine-based activation motifs (ITAMs). ...ITAMi sig …
Tyrosine phosphorylation and Fcgamma receptor-mediated phagocytosis.
Strzelecka A, Kwiatkowska K, Sobota A. Strzelecka A, et al. FEBS Lett. 1997 Jan 2;400(1):11-4. doi: 10.1016/s0014-5793(96)01359-2. FEBS Lett. 1997. PMID: 9000504 Review.
Interaction of the receptors with Fc domains of IgG triggers transduction of phagocytic signal in which a key role is played by phosphorylation of tyrosine residues of the receptors. These residues are arranged into a specific motif (immunoreceptor tyrosine-based ac …
Interaction of the receptors with Fc domains of IgG triggers transduction of phagocytic signal in which a key role is played by phosphorylat …
Molecular Characterization of a B Cell Adaptor for Phosphoinositide 3-Kinase Homolog in Lamprey (Lampetra japonica) and Its Function in the Immune Response.
Chai M, Liu X, Wei L, Li J, Gou M, Zhu T, Han Y, Liu X. Chai M, et al. Int J Mol Sci. 2022 Nov 21;23(22):14449. doi: 10.3390/ijms232214449. Int J Mol Sci. 2022. PMID: 36430927 Free PMC article.
However, after the knockdown of Lja-BCAP by RNAi in vivo, the activation of tyrosine kinases was inhibited in the above tissues, which indicated that Lja-BCAP participated in the anti-bacterial immune response of lampreys. ...The above results show that Lja-BCAP mai …
However, after the knockdown of Lja-BCAP by RNAi in vivo, the activation of tyrosine kinases was inhibited in the above tissues, whic …
Peroxynitrite: cellular pathology and implications in autoimmunity.
Ahmad R, Hussain A, Ahsan H. Ahmad R, et al. J Immunoassay Immunochem. 2019;40(2):123-138. doi: 10.1080/15321819.2019.1583109. Epub 2019 Mar 7. J Immunoassay Immunochem. 2019. PMID: 30843753 Review.
The free radical-mediated damage to proteins results in the modification of amino acid residues, cross-linking of side chains and fragmentation. Free/protein-bound tyrosines are attacked by various reactive nitrogen species (RNS), including peroxynitrite, to form free/prot …
The free radical-mediated damage to proteins results in the modification of amino acid residues, cross-linking of side chains and fragmentat …
Immune function responds to selection for cuticular colour in Tenebrio molitor.
Armitage SA, Siva-Jothy MT. Armitage SA, et al. Heredity (Edinb). 2005 Jun;94(6):650-6. doi: 10.1038/sj.hdy.6800675. Heredity (Edinb). 2005. PMID: 15815710
Given that cuticular colour has a heritable component, we have taken an experimental evolution approach: we selected 10 lines for black and 10 lines for tan adult cuticular phenotypes over at least six generations and measured the correlated responses to selection in a range of …
Given that cuticular colour has a heritable component, we have taken an experimental evolution approach: we selected 10 lines for black and …
15,877 results
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