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Year Number of Results
1982 4
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39,507 results

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Page 1
The NEDD4 ubiquitin E3 ligase: a snapshot view of its functional activity and regulation.
Sicari D, Weber J, Maspero E, Polo S. Sicari D, et al. Biochem Soc Trans. 2022 Feb 28;50(1):473-485. doi: 10.1042/BST20210731. Biochem Soc Trans. 2022. PMID: 35129615 Review.
Being responsible for chain specificity and substrate recognition, E3 ligases are the selective elements of the ubiquitination process. In this review, we discuss different cellular pathways regulated by one of the first identified E3 ligase, NEDD4, focusing on its …
Being responsible for chain specificity and substrate recognition, E3 ligases are the selective elements of the ubiquitination proces …
The Nedd4L ubiquitin ligase is activated by FCHO2-generated membrane curvature.
Sakamoto Y, Uezu A, Kikuchi K, Kang J, Fujii E, Moroishi T, Suetsugu S, Nakanishi H. Sakamoto Y, et al. EMBO J. 2024 Dec;43(23):5883-5909. doi: 10.1038/s44318-024-00268-1. Epub 2024 Oct 14. EMBO J. 2024. PMID: 39402328 Free PMC article.
Nedd4L is catalytically autoinhibited by an intramolecular interaction between its C2 and HECT domains, but the protein's activation mechanism is poorly understood. Here, we show that Nedd4L activation is linked to membrane shape by FCHO2, a Bin-Amphiphysin-R …
Nedd4L is catalytically autoinhibited by an intramolecular interaction between its C2 and HECT domains, but the protein's activati …
Ubiquitin-protein ligases--novel therapeutic targets?
Robinson PA, Ardley HC. Robinson PA, et al. Curr Protein Pept Sci. 2004 Jun;5(3):163-76. doi: 10.2174/1389203043379800. Curr Protein Pept Sci. 2004. PMID: 15180521 Review.
The key components that regulate substrate ubiquitylation are the ubiquitin-protein ligases. Ligases come in many forms, from single proteins to very large multiprotein complexes. ...In this review, we aim to highlight examples of diseases where …
The key components that regulate substrate ubiquitylation are the ubiquitin-protein ligases. Ligases come in man …
Activity of a ubiquitin ligase adaptor is regulated by disordered insertions in its arrestin domain.
Baile MG, Guiney EL, Sanford EJ, MacGurn JA, Smolka MB, Emr SD. Baile MG, et al. Mol Biol Cell. 2019 Dec 1;30(25):3057-3072. doi: 10.1091/mbc.E19-08-0451. Epub 2019 Oct 16. Mol Biol Cell. 2019. PMID: 31618110 Free PMC article.
The protein composition of the plasma membrane is rapidly remodeled in response to changes in nutrient availability or cellular stress. This occurs, in part, through the selective ubiquitylation and endocytosis of plasma membrane proteins, which in the yeast Saccharomyces …
The protein composition of the plasma membrane is rapidly remodeled in response to changes in nutrient availability or cellular stres …
Reconstitution and Structural Analysis of a HECT Ligase-Ubiquitin Complex via an Activity-Based Probe.
Nair RM, Seenivasan A, Liu B, Chen D, Lowe ED, Lorenz S. Nair RM, et al. ACS Chem Biol. 2021 Sep 17;16(9):1615-1621. doi: 10.1021/acschembio.1c00433. Epub 2021 Aug 17. ACS Chem Biol. 2021. PMID: 34403242 Free PMC article.
Ubiquitin activity-based probes have proven invaluable in elucidating structural mechanisms in the ubiquitin system by stabilizing transient macromolecular complexes of deubiquitinases, ubiquitin-activating enzymes, and the assemblies of …
Ubiquitin activity-based probes have proven invaluable in elucidating structural mechanisms in the ubiquitin system by …
Ubiquitin-protein ligase activity of X-linked inhibitor of apoptosis protein promotes proteasomal degradation of caspase-3 and enhances its anti-apoptotic effect in Fas-induced cell death.
Suzuki Y, Nakabayashi Y, Takahashi R. Suzuki Y, et al. Proc Natl Acad Sci U S A. 2001 Jul 17;98(15):8662-7. doi: 10.1073/pnas.161506698. Epub 2001 Jul 10. Proc Natl Acad Sci U S A. 2001. PMID: 11447297 Free PMC article.
A proteasome inhibitor suppressed the degradation of caspase-3 by XIAP, suggesting the involvement of a ubiquitin-proteasome pathway in the degradation. An in vitro ubiquitination assay revealed that XIAP acts as a ubiquitin-protein ligase for caspase- …
A proteasome inhibitor suppressed the degradation of caspase-3 by XIAP, suggesting the involvement of a ubiquitin-proteasome pathway …
Proteasome-associated HECT-type ubiquitin ligase activity is required for plant immunity.
Furniss JJ, Grey H, Wang Z, Nomoto M, Jackson L, Tada Y, Spoel SH. Furniss JJ, et al. PLoS Pathog. 2018 Nov 20;14(11):e1007447. doi: 10.1371/journal.ppat.1007447. eCollection 2018 Nov. PLoS Pathog. 2018. PMID: 30458055 Free PMC article.
Here we show that specific members of the HECT domain-containing family of ubiquitin protein ligases (UPL) play important roles in proteasomal substrate processing during plant immunity. ...Taken together, our findings suggest that proteasome-associated ub …
Here we show that specific members of the HECT domain-containing family of ubiquitin protein ligases (UPL) play importa …
The ubiquitin system for protein degradation and some of its roles in the control of the cell division cycle.
Hershko A. Hershko A. Cell Death Differ. 2005 Sep;12(9):1191-7. doi: 10.1038/sj.cdd.4401702. Cell Death Differ. 2005. PMID: 16094395 Review.
Owing to the intensive research activity on protein synthesis, little attention was paid in the 1950s and 1960s to protein degradation. However, work by my group and others between 1970 and 1990 led to the identification of the ubiquitin-dependent degr …
Owing to the intensive research activity on protein synthesis, little attention was paid in the 1950s and 1960s to protein …
The cyclin-ubiquitin ligase activity of cyclosome/APC is jointly activated by protein kinases Cdk1-cyclin B and Plk.
Golan A, Yudkovsky Y, Hershko A. Golan A, et al. J Biol Chem. 2002 May 3;277(18):15552-7. doi: 10.1074/jbc.M111476200. Epub 2002 Feb 21. J Biol Chem. 2002. PMID: 11859075 Free article.
It becomes enzymatically active at the end of mitosis. The activation of the cyclosome is initiated by its phosphorylation, a process necessary for its conversion to an active form by the ancillary protein Cdc20/Fizzy. ...However, following phosphoryla …
It becomes enzymatically active at the end of mitosis. The activation of the cyclosome is initiated by its phosphorylation, a …
Multiple forms of ubiquitin-protein ligase. Binding of activated ubiquitin to protein substrates.
Lee PL, Midelfort CF, Murakami K, Hatcher VB. Lee PL, et al. Biochemistry. 1986 Jun 3;25(11):3134-8. doi: 10.1021/bi00359a010. Biochemistry. 1986. PMID: 3015198
Enzyme activities that catalyzed the covalent attachment of ubiquitin to protein substrates (ubiquitin-protein ligase, UbL) were purified from the extracts of human red blood cells. These activities required the presence of ubiq …
Enzyme activities that catalyzed the covalent attachment of ubiquitin to protein substrates (ubiquitin-protei …
39,507 results
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