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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1982 3
1983 3
1984 3
1985 3
1986 4
1987 12
1988 26
1989 21
1990 42
1991 73
1992 76
1993 100
1994 163
1995 247
1996 329
1997 456
1998 575
1999 730
2000 842
2001 1109
2002 1211
2003 1429
2004 1735
2005 1963
2006 2296
2007 2413
2008 2612
2009 2759
2010 2989
2011 3246
2012 3531
2013 3506
2014 3556
2015 3588
2016 3452
2017 3320
2018 3119
2019 3207
2020 3455
2021 3242
2022 3098
2023 2986
2024 3445
2025 3691
2026 1001

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67,908 results

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Page 1
A peroxisomal ubiquitin ligase complex forms a retrotranslocation channel.
Feng P, Wu X, Erramilli SK, Paulo JA, Knejski P, Gygi SP, Kossiakoff AA, Rapoport TA. Feng P, et al. Nature. 2022 Jul;607(7918):374-380. doi: 10.1038/s41586-022-04903-x. Epub 2022 Jun 29. Nature. 2022. PMID: 35768507 Free PMC article.
Recycling requires receptor modification by a membrane-embedded ubiquitin ligase complex comprising three RING finger domain-containing proteins (Pex2, Pex10 and Pex12)(5,6). ...Our results clarify a crucial step during peroxisomal protein import and r …
Recycling requires receptor modification by a membrane-embedded ubiquitin ligase complex comprising three RING finger d …
Ubiquitin-binding domains.
Hurley JH, Lee S, Prag G. Hurley JH, et al. Biochem J. 2006 Nov 1;399(3):361-72. doi: 10.1042/BJ20061138. Biochem J. 2006. PMID: 17034365 Free PMC article. Review.
The structures of many of the complexes with mono-ubiquitin have been determined, revealing interactions with multiple surfaces on ubiquitin. ...At least one of these domains, the A20 ZnF, acts as a ubiquitin ligase by recruiting a ubiquitin …
The structures of many of the complexes with mono-ubiquitin have been determined, revealing interactions with multiple surface …
The COP9 signalosome.
Wei N, Deng XW. Wei N, et al. Annu Rev Cell Dev Biol. 2003;19:261-86. doi: 10.1146/annurev.cellbio.19.111301.112449. Annu Rev Cell Dev Biol. 2003. PMID: 14570571 Review.
Recently, CSN was revealed to have a metalloprotease activity centered in the CSN5/Jab1 subunit, which removes the post-translational modification of a ubiquitin-like protein, Nedd8/Rub1, from the cullin component of SCF ubiquitin E3 ligase (i.e., de-n …
Recently, CSN was revealed to have a metalloprotease activity centered in the CSN5/Jab1 subunit, which removes the post-translational modifi …
Nanobody-targeted E3-ubiquitin ligase complex degrades nuclear proteins.
Shin YJ, Park SK, Jung YJ, Kim YN, Kim KS, Park OK, Kwon SH, Jeon SH, Trinh le A, Fraser SE, Kee Y, Hwang BJ. Shin YJ, et al. Sci Rep. 2015 Sep 16;5:14269. doi: 10.1038/srep14269. Sci Rep. 2015. PMID: 26373678 Free PMC article.
Targeted protein degradation is a powerful tool in determining the function of specific proteins or protein complexes. We fused nanobodies to SPOP, an adaptor protein of the Cullin-RING E3 ubiquitin ligase complex, resulting in rap …
Targeted protein degradation is a powerful tool in determining the function of specific proteins or protein complexes. …
Special Issue on "Proteostasis and Autophagy".
Kern A, Behl C. Kern A, et al. Cells. 2019 Jun 26;8(7):642. doi: 10.3390/cells8070642. Cells. 2019. PMID: 31247988 Free PMC article.
Autophagy is a highly conserved eukaryotic pathway responsible for the lysosomal degradation (and subsequent recycling) of cellular components such as proteins, protein aggregates, and a growing number of organelles or cellular compartments [...]....
Autophagy is a highly conserved eukaryotic pathway responsible for the lysosomal degradation (and subsequent recycling) of cellular componen …
UV-induced ubiquitylation of XPC complex, the UV-DDB-ubiquitin ligase complex, and DNA repair.
Sugasawa K. Sugasawa K. J Mol Histol. 2006 Sep;37(5-7):189-202. doi: 10.1007/s10735-006-9044-7. Epub 2006 Jul 21. J Mol Histol. 2006. PMID: 16858626 Review.
For initiation of the repair reaction at the genome-wide level, a complex containing one of the gene products involved in XP, the XPC protein, must bind to the damaged DNA site. ...However, the recent discovery of the association of UV-DDB with a cullin-based ubi …
For initiation of the repair reaction at the genome-wide level, a complex containing one of the gene products involved in XP, the XPC …
Separating sister chromatids.
Nasmyth K. Nasmyth K. Trends Biochem Sci. 1999 Mar;24(3):98-104. doi: 10.1016/s0968-0004(99)01358-4. Trends Biochem Sci. 1999. PMID: 10203756 Review.
Recent work has identified both a cohesin complex that holds sisters together and a sister-separating protein, separin, that destroys cohesion. Separins are bound by inhibitory proteins whose proteolysis at the metaphase-anaphase transition is mediated by the anapha …
Recent work has identified both a cohesin complex that holds sisters together and a sister-separating protein, separin, that d …
Selective recruitment of an E2~ubiquitin complex by an E3 ubiquitin ligase.
Spratt DE, Wu K, Kovacev J, Pan ZQ, Shaw GS. Spratt DE, et al. J Biol Chem. 2012 May 18;287(21):17374-17385. doi: 10.1074/jbc.M112.353748. Epub 2012 Mar 20. J Biol Chem. 2012. PMID: 22433864 Free PMC article.
RING-box protein 1 (Rbx1/ROC1) is a key protein found in the Skp1/Cullin-1/F-box (SCF) E3 ubiquitin ligase complex that functions with the E2 ubiquitin conjugating enzyme CDC34. ...Furthermore, NMR and biochemical assays identified residu …
RING-box protein 1 (Rbx1/ROC1) is a key protein found in the Skp1/Cullin-1/F-box (SCF) E3 ubiquitin ligase co …
UV-induced ubiquitylation of XPC protein mediated by UV-DDB-ubiquitin ligase complex.
Sugasawa K, Okuda Y, Saijo M, Nishi R, Matsuda N, Chu G, Mori T, Iwai S, Tanaka K, Tanaka K, Hanaoka F. Sugasawa K, et al. Cell. 2005 May 6;121(3):387-400. doi: 10.1016/j.cell.2005.02.035. Cell. 2005. PMID: 15882621 Free article.
The xeroderma pigmentosum group C (XPC) protein complex plays a key role in recognizing DNA damage throughout the genome for mammalian nucleotide excision repair (NER). ...XPC and UV-DDB were demonstrated to interact physically, and both are polyubiquitylated by the …
The xeroderma pigmentosum group C (XPC) protein complex plays a key role in recognizing DNA damage throughout the genome for m …
G Protein Mono-ubiquitination by the Rsp5 Ubiquitin Ligase.
Torres MP, Lee MJ, Ding F, Purbeck C, Kuhlman B, Dokholyan NV, Dohlman HG. Torres MP, et al. J Biol Chem. 2009 Mar 27;284(13):8940-50. doi: 10.1074/jbc.M809058200. Epub 2009 Jan 27. J Biol Chem. 2009. PMID: 19176477 Free PMC article.
Emerging evidence suggests that ubiquitination serves as a protein trafficking signal in addition to its well characterized role in promoting protein degradation. The yeast G protein alpha subunit Gpa1 represents a rare example of a protein that underg …
Emerging evidence suggests that ubiquitination serves as a protein trafficking signal in addition to its well characterized role in p …
67,908 results
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