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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1986 2
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5,931 results

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Page 1
PINK1 phosphorylates ubiquitin to activate Parkin E3 ubiquitin ligase activity.
Kane LA, Lazarou M, Fogel AI, Li Y, Yamano K, Sarraf SA, Banerjee S, Youle RJ. Kane LA, et al. J Cell Biol. 2014 Apr 28;205(2):143-53. doi: 10.1083/jcb.201402104. Epub 2014 Apr 21. J Cell Biol. 2014. PMID: 24751536 Free PMC article.
PINK1 kinase activates the E3 ubiquitin ligase Parkin to induce selective autophagy of damaged mitochondria. ...Recombinant TcPINK1 directly phosphorylated ubiquitin and phospho-ubiquitin activated Parkin E3 ubiquitin ligase activity in cell-free assays. In c …
PINK1 kinase activates the E3 ubiquitin ligase Parkin to induce selective autophagy of damaged mitochondria. ...Recombinant TcPINK1 d …
PINK1/Parkin-mediated mitophagy in mammalian cells.
Eiyama A, Okamoto K. Eiyama A, et al. Curr Opin Cell Biol. 2015 Apr;33:95-101. doi: 10.1016/j.ceb.2015.01.002. Epub 2015 Feb 17. Curr Opin Cell Biol. 2015. PMID: 25697963 Review.
Notably, ubiquitin and deubiquitinases play vital roles in modulating Parkin activity and mitophagy efficiency. In this review, we highlight recent breakthroughs addressing the key issues of how PINK1 activates Parkin in response to mitochondrial malfunction, how Pa …
Notably, ubiquitin and deubiquitinases play vital roles in modulating Parkin activity and mitophagy efficiency. In this review, we hi …
Parkin and PINK1 mitigate STING-induced inflammation.
Sliter DA, Martinez J, Hao L, Chen X, Sun N, Fischer TD, Burman JL, Li Y, Zhang Z, Narendra DP, Cai H, Borsche M, Klein C, Youle RJ. Sliter DA, et al. Nature. 2018 Sep;561(7722):258-262. doi: 10.1038/s41586-018-0448-9. Epub 2018 Aug 22. Nature. 2018. Retraction in: Nature. 2025 Aug;644(8078):1116. doi: 10.1038/s41586-025-09346-8. PMID: 30135585 Free PMC article. Retracted.
Mitochondrial stress can lead to the release of damage-associated molecular patterns (DAMPs) that can activate innate immunity(8-12), suggesting that mitophagy may mitigate inflammation. Here we report a strong inflammatory phenotype in both Prkn(-/-) and Pink1(-/-) mice f …
Mitochondrial stress can lead to the release of damage-associated molecular patterns (DAMPs) that can activate innate immunity(8-12), …
Centromeric DNA amplification triggered by viral proteins activates nuclear cGAS.
Lahaye X, Tran Van P, Chakraborty C, Shmakova A, Cao NTB, Ferran H, Ait-Mohamed O, Maurin M, Waterfall JJ, Kaufer BB, Fischer P, Hennig T, Dölken L, Lomonte P, Fachinetti D, Manel N. Lahaye X, et al. Cell. 2025 Jul 24;188(15):4043-4057.e21. doi: 10.1016/j.cell.2025.05.008. Epub 2025 Jun 2. Cell. 2025. PMID: 40460826 Free article.
While cytosolic cGAS detects viral DNA, most DNA viruses shield their genome and invade the nucleus, where chromatin restricts cGAS activation. How viruses may activate nuclear cGAS is not well understood. Here, we show that several herpesvirus proteins trigger nucl …
While cytosolic cGAS detects viral DNA, most DNA viruses shield their genome and invade the nucleus, where chromatin restricts cGAS activ …
ALDOA maintains NLRP3 inflammasome activation by controlling AMPK activation.
Bai D, Du J, Bu X, Cao W, Sun T, Zhao J, Zhao Y, Lu N. Bai D, et al. Autophagy. 2022 Jul;18(7):1673-1693. doi: 10.1080/15548627.2021.1997051. Epub 2021 Nov 25. Autophagy. 2022. PMID: 34821530 Free PMC article.
ALDOA: aldolase A; AMPK: AMP-activated protein kinase; ATG: autophagy related; ATG5: autophagy related 5; ATP: adenosine triphosphate; BMDMs: bone marrow-derived macrophages; CALCOCO2: calcium binding and coiled-coil domain 2; CASP1: caspase 1; CQ: chloroquine; FOXO3: fork …
ALDOA: aldolase A; AMPK: AMP-activated protein kinase; ATG: autophagy related; ATG5: autophagy related 5; ATP: adenosine triphosphate …
Activation of TIR signalling boosts pattern-triggered immunity.
Tian H, Wu Z, Chen S, Ao K, Huang W, Yaghmaiean H, Sun T, Xu F, Zhang Y, Wang S, Li X, Zhang Y. Tian H, et al. Nature. 2021 Oct;598(7881):500-503. doi: 10.1038/s41586-021-03987-1. Epub 2021 Sep 20. Nature. 2021. PMID: 34544113
NLRs possessing amino-terminal Toll/interleukin-1 receptor (TIR) domains activate defence responses via the NADase activity of the TIR domain(2,3). Here we report that activation of TIR signalling has a key role in pattern-triggered immunity (PTI) mediated by …
NLRs possessing amino-terminal Toll/interleukin-1 receptor (TIR) domains activate defence responses via the NADase activity of …
Mitochondrial-Endoplasmic Reticulum Communication-Mediated Oxidative Stress and Autophagy.
Liu X, Hussain R, Mehmood K, Tang Z, Zhang H, Li Y. Liu X, et al. Biomed Res Int. 2022 Sep 17;2022:6459585. doi: 10.1155/2022/6459585. eCollection 2022. Biomed Res Int. 2022. PMID: 36164446 Free PMC article. Review.
Oxidative stress is an imbalance between free radicals and the antioxidant system causing overgeneration of free radicals (oxygen-containing molecules) ultimately leading to oxidative damage in terms of lipid peroxidation, protein denaturation, and DNA mutation. Oxidative stress …
Oxidative stress is an imbalance between free radicals and the antioxidant system causing overgeneration of free radicals (oxygen-containing …
Mitophagy: Molecular Mechanisms, New Concepts on Parkin Activation and the Emerging Role of AMPK/ULK1 Axis.
Iorio R, Celenza G, Petricca S. Iorio R, et al. Cells. 2021 Dec 23;11(1):30. doi: 10.3390/cells11010030. Cells. 2021. PMID: 35011593 Free PMC article. Review.
However, other Parkin-independent pathways are also reported to mediate the tethering of mitochondria to the autophagy apparatuses, directly activating mitophagy (mitophagy receptors and other E3 ligases). In addition, the existence of molecular mechanisms other than PINK1 …
However, other Parkin-independent pathways are also reported to mediate the tethering of mitochondria to the autophagy apparatuses, directly …
RAB7 activity is required for the regulation of mitophagy in oocyte meiosis and oocyte quality control during ovarian aging.
Jin X, Wang K, Wang L, Liu W, Zhang C, Qiu Y, Liu W, Zhang H, Zhang D, Yang Z, Wu T, Li J. Jin X, et al. Autophagy. 2022 Mar;18(3):643-660. doi: 10.1080/15548627.2021.1946739. Epub 2021 Jul 7. Autophagy. 2022. PMID: 34229552 Free PMC article.
Our result then demonstrated its association with the decreased activity of RAB7 and all the observed defects in CCCP treated oocytes could be effectively rescued by microinjection of mRNA encoding active RAB7(Q67L) or treatment with the RAB7 activator ML098. …
Our result then demonstrated its association with the decreased activity of RAB7 and all the observed defects in CCCP treated oocytes …
PBK drives PARP inhibitor resistance through the TRIM37/NFκB axis in ovarian cancer.
Ma H, Qi G, Han F, Peng J, Yuan C, Kong B. Ma H, et al. Exp Mol Med. 2022 Jul;54(7):999-1010. doi: 10.1038/s12276-022-00809-w. Epub 2022 Jul 20. Exp Mol Med. 2022. PMID: 35859118 Free PMC article.
Mechanically, PBK directly interacted with TRIM37 to promote its phosphorylation and nuclear translocation. which subsequently activates the NFkappaB pathway. Additionally, PBK enhanced olaparib resistance of ovarian cancer by regulating the NFkappaB/TRIM37 axis in vitro a …
Mechanically, PBK directly interacted with TRIM37 to promote its phosphorylation and nuclear translocation. which subsequently activates …
5,931 results