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317 results

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Page 1
Targeted Delivery of RGD-CD146(+)CD271(+) Human Umbilical Cord Mesenchymal Stem Cell-Derived Exosomes Promotes Blood-Spinal Cord Barrier Repair after Spinal Cord Injury.
Xie Y, Sun Y, Liu Y, Zhao J, Liu Q, Xu J, Qin Y, He R, Yuan F, Wu T, Duan C, Jiang L, Lu H, Hu J. Xie Y, et al. ACS Nano. 2023 Sep 26;17(18):18008-18024. doi: 10.1021/acsnano.3c04423. Epub 2023 Sep 11. ACS Nano. 2023. PMID: 37695238
Spinal cord injury (SCI) disrupts the blood-spinal cord barrier (BSCB), potentially exacerbating nerve damage and emphasizing the criticality of preserving the BSCB integrity during SCI treatment. ...Specific subpopulations of CD146(+)CD271(+) …
Spinal cord injury (SCI) disrupts the blood-spinal cord barrier (BSCB), potentially exacerbating nerve da …
Safety and potential effects of intrathecal injection of allogeneic human umbilical cord mesenchymal stem cell-derived exosomes in complete subacute spinal cord injury: a first-in-human, single-arm, open-label, phase I clinical trial.
Akhlaghpasand M, Tavanaei R, Hosseinpoor M, Yazdani KO, Soleimani A, Zoshk MY, Soleimani M, Chamanara M, Ghorbani M, Deylami M, Zali A, Heidari R, Oraee-Yazdani S. Akhlaghpasand M, et al. Stem Cell Res Ther. 2024 Aug 26;15(1):264. doi: 10.1186/s13287-024-03868-0. Stem Cell Res Ther. 2024. PMID: 39183334 Free PMC article. Clinical Trial.
OBJECTIVE: Neurological and functional impairments are commonly observed in individuals with spinal cord injury (SCI) due to insufficient regeneration of damaged axons. Exosomes play a crucial role in the paracrine effects of mesenchymal stem cells …
OBJECTIVE: Neurological and functional impairments are commonly observed in individuals with spinal cord injury (SCI) d …
Stem cell-based therapy for human diseases.
Hoang DM, Pham PT, Bach TQ, Ngo ATL, Nguyen QT, Phan TTK, Nguyen GH, Le PTT, Hoang VT, Forsyth NR, Heke M, Nguyen LT. Hoang DM, et al. Signal Transduct Target Ther. 2022 Aug 6;7(1):272. doi: 10.1038/s41392-022-01134-4. Signal Transduct Target Ther. 2022. PMID: 35933430 Free PMC article. Review.
Stem cell-based therapy, including human pluripotent stem cells (hPSCs) and multipotent mesenchymal stem cells (MSCs), has recently emerged as a key player in regenerative medicine. hPSCs are defined as self-renewable cell types conferring the a …
Stem cell-based therapy, including human pluripotent stem cells (hPSCs) and multipotent mesenchymal stem cell …
What is the impact of human umbilical cord mesenchymal stem cell transplantation on clinical treatment?
Xie Q, Liu R, Jiang J, Peng J, Yang C, Zhang W, Wang S, Song J. Xie Q, et al. Stem Cell Res Ther. 2020 Dec 1;11(1):519. doi: 10.1186/s13287-020-02011-z. Stem Cell Res Ther. 2020. PMID: 33261658 Free PMC article. Review.
BACKGROUND: Human umbilical cord mesenchymal stem cells (HUC-MSCs) present in the umbilical cord tissue are self-renewing and multipotent. ...These characteristics of HUC-MSCs are discussed in the context of diabetes and its complications …
BACKGROUND: Human umbilical cord mesenchymal stem cells (HUC-MSCs) present in the umbilical cord t …
Extracellular vesicle-loaded hydrogels for tissue repair and regeneration.
Ju Y, Hu Y, Yang P, Xie X, Fang B. Ju Y, et al. Mater Today Bio. 2022 Dec 21;18:100522. doi: 10.1016/j.mtbio.2022.100522. eCollection 2023 Feb. Mater Today Bio. 2022. PMID: 36593913 Free PMC article. Review.
Extracellular vesicles (EVs) are a collective term for nanoscale or microscale vesicles secreted by cells that play important biological roles. Mesenchymal stem cells are a class of cells with the potential for self-healing and multidirectional differe …
Extracellular vesicles (EVs) are a collective term for nanoscale or microscale vesicles secreted by cells that play important biologi …
Bioactive scaffolds with enhanced supramolecular motion promote recovery from spinal cord injury.
Álvarez Z, Kolberg-Edelbrock AN, Sasselli IR, Ortega JA, Qiu R, Syrgiannis Z, Mirau PA, Chen F, Chin SM, Weigand S, Kiskinis E, Stupp SI. Álvarez Z, et al. Science. 2021 Nov 12;374(6569):848-856. doi: 10.1126/science.abh3602. Epub 2021 Nov 11. Science. 2021. PMID: 34762454 Free PMC article.
The signaling of cells by scaffolds of synthetic molecules that mimic proteins is known to be effective in the regeneration of tissues. Here, we describe peptide amphiphile supramolecular polymers containing two distinct signals and test them in a mouse model of severe …
The signaling of cells by scaffolds of synthetic molecules that mimic proteins is known to be effective in the regeneration of tissue …
The optimal transplantation strategy of umbilical cord mesenchymal stem cells in spinal cord injury: a systematic review and network meta-analysis based on animal studies.
Lu Y, Zhang W, Tian Z, Liang Q, Liu C, Wu Y, Zhang L, Rong L. Lu Y, et al. Stem Cell Res Ther. 2022 Sep 2;13(1):441. doi: 10.1186/s13287-022-03103-8. Stem Cell Res Ther. 2022. PMID: 36056386 Free PMC article.
OBJECTIVE: Umbilical cord mesenchymal stem cells (UCMSCs) have great potential in the treatment of spinal cord injury. ...
OBJECTIVE: Umbilical cord mesenchymal stem cells (UCMSCs) have great potential in the treatment of spinal …
Targeted Repair of Spinal Cord Injury Based on miRNA-124-3p-Loaded Mesoporous Silica Camouflaged by Stem Cell Membrane Modified with Rabies Virus Glycoprotein.
Fan X, Shi L, Yang Z, Li Y, Zhang C, Bai B, Chen L, Yilihamu EE, Qi Z, Li W, Xiao P, Liu M, Qiu J, Yang F, Ran N, Shang Y, Liu J, Zhang T, Kong X, Liu H, Zhou H, Feng S. Fan X, et al. Adv Sci (Weinh). 2024 Jun;11(21):e2309305. doi: 10.1002/advs.202309305. Epub 2024 Mar 21. Adv Sci (Weinh). 2024. PMID: 38509833 Free PMC article.
Spinal cord injury (SCI) has no effective treatment modalities. It faces a significant global therapeutical challenge, given its features of poor axon regeneration, progressive local inflammation, and inefficient systemic drug delivery due to the blood-spi …
Spinal cord injury (SCI) has no effective treatment modalities. It faces a significant global therapeutical challenge, …
Stem cell exosome-loaded Gelfoam improves locomotor dysfunction and neuropathic pain in a rat model of spinal cord injury.
Poongodi R, Yang TH, Huang YH, Yang KD, Chen HZ, Chu TY, Wang TY, Lin HC, Cheng JK. Poongodi R, et al. Stem Cell Res Ther. 2024 May 20;15(1):143. doi: 10.1186/s13287-024-03758-5. Stem Cell Res Ther. 2024. PMID: 38764049 Free PMC article.
BACKGROUND: Spinal cord injury (SCI) is a debilitating illness in humans that causes permanent loss of movement or sensation. To treat SCI, exosomes, with their unique benefits, can circumvent limitations through direct stem cell transplantation. There …
BACKGROUND: Spinal cord injury (SCI) is a debilitating illness in humans that causes permanent loss of movement or sens …
Human Mesenchymal Stem Cells for Spinal Cord Injury.
Alishahi M, Anbiyaiee A, Farzaneh M, Khoshnam SE. Alishahi M, et al. Curr Stem Cell Res Ther. 2020;15(4):340-348. doi: 10.2174/1574888X15666200316164051. Curr Stem Cell Res Ther. 2020. PMID: 32178619 Review.
Spinal Cord Injury (SCI), as a devastating and life-altering neurological disorder, is one of the most serious health issues. ...These cells are often isolated from bone marrow (BM-MSCs), adipose tissues (AD-MSCs), umbilical cord blood (U …
Spinal Cord Injury (SCI), as a devastating and life-altering neurological disorder, is one of the most serious health i …
317 results