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Obesity reduced survival with 5-fluorouracil and did not protect against chemotherapy-induced cachexia or immune cell cytotoxicity in mice.
VanderVeen BN, Cardaci TD, McDonald SJ, Madero SS, Unger CA, Bullard BM, Enos RT, Velázquez KT, Kubinak JL, Fan D, Murphy EA. VanderVeen BN, et al. Cancer Biol Ther. 2022 Dec 31;23(1):1-15. doi: 10.1080/15384047.2022.2108306. Cancer Biol Ther. 2022. PMID: 35968771 Free PMC article.
C56BL/6 mice were given high fat (Obese) or standard diets (Lean) for 4 months and then subjected to three cycles of 5FU (5d-40 mg/kg Lean Mass, 9d rest) or PBS vehicle control. Shockingly, only 60% of Obese survived 3 cycles compared to 100% of Lean, and Obese lost signif …
C56BL/6 mice were given high fat (Obese) or standard diets (Lean) for 4 months and then subjected to three cycles of 5FU (5d-40 mg/kg …
Assessing health-related quality of life in primary Sjögren's syndrome-The PSS-QoL.
Lackner A, Stradner MH, Hermann J, Unger J, Stamm T, Graninger WB, Dejaco C. Lackner A, et al. Semin Arthritis Rheum. 2018 Aug;48(1):105-110. doi: 10.1016/j.semarthrit.2017.11.007. Epub 2017 Nov 27. Semin Arthritis Rheum. 2018. PMID: 29395257
Convergent construct validity was assessed by correlating the score with the EULAR Sjogren's Syndrome Patient Reported Index (ESSPRI), EULAR Sjogren's Syndrome Disease Activity Index (ESSDAI) and Euro-QoL 5D (EQ-5D). Reliability was examined by asking patients to co …
Convergent construct validity was assessed by correlating the score with the EULAR Sjogren's Syndrome Patient Reported Index (ESSPRI), EULAR …
One year follow-up of physical performance and quality of life in patients surviving COVID-19: a prospective cohort study.
Betschart M, Rezek S, Unger I, Ott N, Beyer S, Böni A, Gisi D, Shannon H, Spruit MA, Sieber C. Betschart M, et al. Swiss Med Wkly. 2021 Oct 28;151:w30072. doi: 10.4414/smw.2021.w30072. eCollection 2021 Oct 25. Swiss Med Wkly. 2021. PMID: 34751538 Free article.
Participants were assessed for physical performance (six-minute walk test), HRQoL (EQ-5D-5L), COVID-19 related limitations in functionality (PCFS), hospital-related anxiety and depression (HADS-A/-D), lung function (FEV1, FVC) and dyspnea during activity (mMRC). ...
Participants were assessed for physical performance (six-minute walk test), HRQoL (EQ-5D-5L), COVID-19 related limitations in functio …
Osteogenesis imperfecta: towards an individualised interdisciplinary care strategy to improve physical activity and quality of life.
Aubry-Rozier B, Richard C, Unger S, Hans D, Campos-Xavier B, Schneider P, Paquier C, Pasche J, Bonafé L, Bregou A. Aubry-Rozier B, et al. Swiss Med Wkly. 2020 Jul 6;150:w20285. doi: 10.4414/smw.2020.20285. eCollection 2020 Jun 28. Swiss Med Wkly. 2020. PMID: 32667677 Free article.
Our second aim was to evaluate the evolution of physical activity, quality of life (measured by EQ-5D, SF-36 and a dedicated questionnaire) and satisfaction of patients and their families. ...Over a 7-year period, 62% of inactive patients started some physical activity, an …
Our second aim was to evaluate the evolution of physical activity, quality of life (measured by EQ-5D, SF-36 and a dedicated question …
Safety and QOL in Patients with Advanced NET in a Phase 3b Expanded Access Study of Everolimus.
Pavel M, Unger N, Borbath I, Ricci S, Hwang TL, Brechenmacher T, Park J, Herbst F, Beaumont JL, Bechter O. Pavel M, et al. Target Oncol. 2016 Oct;11(5):667-675. doi: 10.1007/s11523-016-0440-y. Target Oncol. 2016. PMID: 27193465 Clinical Trial.
HRQOL was assessed at baseline, for three 28-day cycles, and then at every three cycles until end of treatment (EOT) with EQ-5D, EORTC QLQ-C30, and EORTC QLQ-GINET21 instruments. RESULTS: The most common grade 3 or 4 AEs included hyperglycemia, infections, stomatitis, fati …
HRQOL was assessed at baseline, for three 28-day cycles, and then at every three cycles until end of treatment (EOT) with EQ-5D, EORT …